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Chemical Structure| 3970-42-1 Chemical Structure| 3970-42-1

Structure of 3970-42-1

Chemical Structure| 3970-42-1

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Product Details of [ 3970-42-1 ]

CAS No. :3970-42-1
Formula : C11H13ClN2O2
M.W : 240.69
SMILES Code : ClC1=CC=CC([N+]([O-])=O)=C1N2CCCCC2
MDL No. :MFCD06408854

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Application In Synthesis of [ 3970-42-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 3970-42-1 ]

[ 3970-42-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2106-49-2 ]
  • [ 3970-42-1 ]
YieldReaction ConditionsOperation in experiment
85.8% With piperidine; potassium carbonate; In N,N-dimethyl-formamide; at 60℃; for 12h; l-chloro-2-fluoro-3-nitrobenzene (A84.1) (0.300 g, 1.7 mmol) was added to a stirred solution of piperidine (A84.2) (0.286 g, 3.4 mmol) and potassium carbonate (0.352 g, 2.55 mmol) in dry DMF (5 mL). The mixture was stirred at 60 C until the reaction completion (TLC control) and concentrated under the reduced pressure. The residue was dissolved in ethyl acetate (15 mL), the organic layer was washed with water (15 mL x 2), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to obtain crude l-(2-chloro-6-nitrophenyl)piperidine as orange oil (A84.3) (0.37 g, 1.53 mmol, 95% purity, 85.8% yield).
 

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