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Chemical Structure| 39512-49-7 Chemical Structure| 39512-49-7
Chemical Structure| 39512-49-7

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Product Details of 4-(4-Chlorophenyl)-4-hydroxypiperidine

CAS No. :39512-49-7
Formula : C11H14ClNO
M.W : 211.69
SMILES Code : OC1(C2=CC=C(Cl)C=C2)CCNCC1
MDL No. :MFCD00006001
InChI Key :LZAYOZUFUAMFLD-UHFFFAOYSA-N
Pubchem ID :38282

Safety of 4-(4-Chlorophenyl)-4-hydroxypiperidine

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 4-(4-Chlorophenyl)-4-hydroxypiperidine

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 39512-49-7 ]

[ 39512-49-7 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 401564-36-1 ]
  • [ 39512-49-7 ]
  • 3-{(2S,4S)-1-tert-butoxycarbonyl-4-[4-(4-chlorophenyl)-4-hydroxypiperidino]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium cyanoborohydride; acetic acid; In methanol; water; (1) The title compound (593 mg) of Reference Example 12 was dissolved in methanol (10 mL), and 4-(4-chlorophenyl)-4-hydroxypiperidine (500 mg), acetic acid (113 muL) and sodium cyanoborohydride (124 mg) were added thereto at room temperature. The mixture was stirred for 21 hr. Water was added to the reaction mixture, and the mixture was extracted with chloroform. The extract was washed with brine and dried. The solvent was evaporated under reduced pressure to give 3-{(2S,4S)-1-tert-butoxycarbonyl-4-[4-(4-chlorophenyl)-4-hydroxypiperidino]-2-pyrrolidinylcarbonyl}-1,3-thiazolidine (428 mg) as a white solid.
  • 2
  • [ 940890-90-4 ]
  • [ 39512-49-7 ]
  • (3'R)-4-(4-chlorophenyl)-1,3'-bipiperidin-4-ol [ No CAS ]
  • 3
  • [ 39512-49-7 ]
  • [ 129722-34-5 ]
  • [ 1314032-10-4 ]
YieldReaction ConditionsOperation in experiment
96% With potassium carbonate; potassium iodide; In acetonitrile;Reflux; Inert atmosphere; A mixture of <strong>[129722-34-5]7-(4-bromobutoxy)-3,4-dihydroquinolin-2(1H)-one</strong> (20, 1.7 mmol), 4-(chlorophenyl)-4-hydroxypiperidine (1.7 mmol), potassium carbonate (5 equiv) and potassium iodide (1 equiv) in acetonitrile (20 mL) was stirred at reflux overnight. The reaction mixture was evaporated. The resulting residue was suspended in water (25 mL) and filtered. The solid was washed with water and air dried to give the product as white powder (96percent yield). The oxalate salt was prepared using 1 equiv of oxalic acid in ethanol and recrystallized from ethanol to give 2 as an off-white powder, mp 178-179 °C; 1H NMR (free base, CDCl3 + DMSO-d6) delta 9.08 (br s, 1H), 7.47 (d, J = 8.7 Hz, 2H), 7.29 (d, J = 8.7 Hz, 2H), 7.02 (d, J = 8.2 Hz, 1H), 6.49 (dd, J = 8.7 and 2.5 Hz, 1H), 6.42 (d, J = 2.5 Hz, 1H), 3.95 (t, J = 6.0 Hz, 2H), 3.50-3.60 (m, 1H), 2.78-2.89 (m, 4H), 2.43-2.62 (m, 6H), 2.02-2.10 (m, 2H), 1.70-1.80 (m, 6H). Anal. (C24H29ClN2O3*C2H2O4*0.5H2O) C, H, N.
  • 4
  • [ 39512-49-7 ]
  • [ 129722-34-5 ]
  • 7-(4-(4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl)butoxy)-3,4-dihydroquinolin-2(1H)-one oxalate [ No CAS ]
 

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