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Chemical Structure| 400611-25-8 Chemical Structure| 400611-25-8

Structure of 400611-25-8

Chemical Structure| 400611-25-8

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Product Details of [ 400611-25-8 ]

CAS No. :400611-25-8
Formula : C17H25NO4S
M.W : 339.45
SMILES Code : CC(C)(C)OC(N[C@H](C([CH-][S+](C)(C)=O)=O)CC1=CC=CC=C1)=O
MDL No. :N/A

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Application In Synthesis of [ 400611-25-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 400611-25-8 ]

[ 400611-25-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 400611-25-8 ]
  • [ 102123-74-0 ]
YieldReaction ConditionsOperation in experiment
81% With methanesulfonic acid; lithium chloride; In tetrahydrofuran; at 0 - 80℃;Product distribution / selectivity; The keto sulfoxonium ylide of compound (5) (6.18 mmol, 2.0 g) from above was dissolved in 30 mL anhydrous THF and the solution was cooled to 0 0C. Lithium chloride (6.80 mmol, 0.29 g) and methanesulfonic acid (6.80 mmol, 0.44 mL) were added. The temperature was slowly raised to room temperature and subsequently to 80 0C. The reaction mixture was stirred at 80 0C for 2 h. After cooling to room temperature, the reaction was quenched by adding 30 mL water. The phases were separated and the aqueous layer was extracted with 30 mL of 2:1 heptane/ethyl acetate. The organic layers were combined and washed with saturated NaHCO3 (2 x 30 mL), water (2 x 25 mL) and brine (2 x 15 mL) and dried over Na2SO4. Concentration under reduced pressure afforded crude alpha-chloroketone of compound (6) (1.5 g, 81% yield) as a yellow semi solid. Crystallization of product from hot 5: 1 heptane/ethyl acetate mixtures yielded 0.30 g of white solid of compound (6) with a purity of 96.8% (by HPLC) and a chiral purity of 99% ee
 

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