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Chemical Structure| 40703-88-6
Chemical Structure| 40703-88-6
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CAS No. :40703-88-6 MDL No. :
Formula : C22H15N3 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 321.37 Pubchem ID :-
Synonyms :

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Application In Synthesis of [ 40703-88-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 40703-88-6 ]

[ 40703-88-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 4181-05-9 ]
  • [ 109-77-3 ]
  • [ 40703-88-6 ]
YieldReaction ConditionsOperation in experiment
96% With piperidine In ethanol at 20℃; for 1h;
94% With sodium carbonate In neat (no solvent) Preparation of DPMP DPMP was synthesized as described in Scheme 1. In detail, 4-diphenyl-aminobenzaldehyde was synthesized in accordance withthe reported method [19]. DPMP was synthesized from 4-diphenylaminobenzaldehydeand malononitrile via solvent-free reactionin 94% yield. FT-IR (KBr, cm1) selected bands: m = 3049 (mCH2, w),2216 (mC„N, s), 2648 (w), 1446 (m), 1186 (s), 821 (w). 1H NMR(400 MHz, CDCl3) d (ppm) 7.74 (d, J = 8.8 Hz, 2H), 7.51 (s, 1H),7.38 (t, J = 8.0 Hz, 4H), 7.25-7.18 (q, 6H), 6.95 (d, J = 9.2 Hz, 2H).13C NMR (100 MHz) d = 75.56, 114.08, 118.48, 122.79, 126.12,126.71, 129.95, 132.98, 145.14, 153.47, 157.89, 166.30. Anal. Calc.for C22H15N3: C, 82.22, H, 4.70, N, 13.08, Found: C, 82.78, H, 4.87,N, 12.74%. MS (EI), m/z (%): 321 ([M+], 100).
89% With aluminum oxide In dichloromethane at 25℃; for 18h;
84% With aluminum oxide In dichloromethane 2.2. Typical Procedure for the Synthesis of Malononitrile Derivatives General procedure: Aluminumtrioxide (0.8 g, 1.6 g and 2.4 g) and appropriate aldehyde(4 mmol) were placed in a glass-stoppered conical flask. Then solutionof malononitrile (8 mmol, 16 mmol and 24 mmol) in methylene chloride(20 cm3) was added. The reaction mixture was stirred until thecomplete disappearance of the starting material was determined bythin layer chromatography. Crude products were purified using columnchromatography (SiO2, CH2Cl2).
81% With piperidine In acetonitrile at 80℃; for 6h; 7 Synthesis of Compound A1 General procedure: 10 mL single-necked flask was added 0.1 gTriphenylaldehyde and 0.036 gMalononitrile,Dissolved in 5mL acetonitrile,Dropping 3 drops of piperidine, 80 under reflux conditions for 6h,After completion of the reaction, the temperature was lowered to room temperature,Poured into the water,filter,Distilled water to wash the precipitate,Column chromatography (petroleum ether: ethyl acetate = 8: 1),0.095 g of a yellow solid, yield 81%
81% With piperidine In acetonitrile at 80℃; for 6h; 1.6 6) Synthesis of Compound A1 Add 10 g of compound 2 and 0.036 g of malononitrile to a 10 mL single-mouth flask, dissolve in 5 mL of acetonitrile, add 3 drops of acridine in drops, and reflux at 80° C. for 6 hours. After the reaction is complete, the reaction solution is allowed to come to room temperature. Water, filtration, precipitation washed with distilled water several times, column chromatography (petroleum ether: ethyl acetate = 8: 1), to obtain 0.095g yellow solid, which is compound A1, yield 81%
80% With triethylamine In dichloromethane at 20℃; for 5h;
78% With triethylamine In ethanol for 24h; Reflux;
53% With sodium acetate; acetic acid In benzene for 11h; Reflux;
With 1H-indene-1,3(2H)-dione In butan-1-ol for 2h; Reflux;
Alkaline conditions;
With hierarchically structured zeolitic imidazolate framework
With piperidine In 1,2-dichloro-ethane at 20℃; for 0.5h;

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[2]Kong, Lin; Yang, Jia-Xiang; Cheng, Long-Jiu; Wang, Peng; Zhou, Hong-Ping; Wu, Jie-Ying; Tian, Yu-Peng; Jin, Bao-Kang; Tao, Xu-Tang [Journal of Molecular Structure, 2014, vol. 1059, # 1, p. 144 - 149]
[3]Klikar; Kityk; Kulwas; Mikysek; Pytela; Bureš [New Journal of Chemistry, 2017, vol. 41, # 4, p. 1459 - 1472]
[4]Sęk, Danuta; Kotowicz, Sonia; Kula, Sławomir; Siwy, Mariola; Szłapa-Kula, Agata; Małecki, Jan Grzegorz; Maćkowski, Sebastian; Schab-Balcerzak, Ewa [Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2019, vol. 210, p. 136 - 147]
[5]Current Patent Assignee: JIANGSU NORMAL UNIVERSITY - CN105038294, 2017, B Location in patent: Paragraph 0096-0098
[6]Current Patent Assignee: JIANGSU NORMAL UNIVERSITY - CN105061256, 2018, B Location in patent: Paragraph 0063; 0079-0081
[7]Tang, Xianglin; Liu, Weimin; Wu, Jiasheng; Lee, Chun-Sing; You, Juanjuan; Wang, Pengfei [Journal of Organic Chemistry, 2010, vol. 75, # 21, p. 7273 - 7278]
[8]Yang, Xiaodong; Chen, Xiuli; Lu, Xiaodan; Yan, Chenggong; Xu, Yikai; Hang, Xiaodong; Qu, Jinqing; Liu, Ruiyuan [Journal of Materials Chemistry C, 2016, vol. 4, # 2, p. 383 - 390]
[9]Location in patent: experimental part Zhou, Fuke; Shao, Jingyin; Yang, Yubin; Zhao, Jianzhang; Guo, Huimin; Li, Xiaolian; Ji, Shaomin; Zhang, Zongying [European Journal of Organic Chemistry, 2011, # 25, p. 4773 - 4787]
[10]Location in patent: experimental part Li, Xiaochuan; Son, Young-A; Kim, Young-Sung; Kim, Sung-Hoon; Kun, Jun; Shin, Jong-Il [Journal of Nanoscience and Nanotechnology, 2012, vol. 12, # 2, p. 1497 - 1502]
[11]Kong, Lin; Yang, Jiaxiang; Zhou, Hongping; Li, Shengli; Hao, Fuying; Zhang, Qiong; Tu, Yulong; Wu, Jieying; Xue, Zhaoming; Tian, Yupeng [Science China Chemistry, 2013, vol. 56, # 1, p. 106 - 116]
[12]Cheng, Kaipeng; Svec, Frantisek; Lv, Yongqin; Tan, Tianwei [Small, 2019, vol. 15, # 44]
[13]Plass, Fabian; Bönisch, Simon; Held, Felix; Ullrich, Tobias; Fischer, Florian E. J.; Guryev, Anton; Görling, Andreas; Kahnt, Axel; Tsogoeva, Svetlana B. [Journal of Organic Chemistry, 2021, vol. 86, # 9, p. 6111 - 6125]
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