Home Cart 0 Sign in  

[ CAS No. 4085-31-8 ] {[proInfo.proName]}

,{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]}
Chemical Structure| 4085-31-8
Chemical Structure| 4085-31-8
Structure of 4085-31-8 * Storage: {[proInfo.prStorage]}
Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Quality Control of [ 4085-31-8 ]

Related Doc. of [ 4085-31-8 ]

Alternatived Products of [ 4085-31-8 ]

Product Details of [ 4085-31-8 ]

CAS No. :4085-31-8 MDL No. :MFCD01237079
Formula : C29H32Cl2N6 Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 535.51 Pubchem ID :-
Synonyms :
Piperaquinoline

Safety of [ 4085-31-8 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H302-H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4085-31-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4085-31-8 ]

[ 4085-31-8 ] Synthesis Path-Downstream   1~5

YieldReaction ConditionsOperation in experiment
resp. Amin, resp. Halogenid;
Stammverb., Dichlorchinolin;
1,3-Dipiperazinopropan (II), 4,7-Dichlorchinolin (I);
  • 2
  • [ 109-64-8 ]
  • [ 837-52-5 ]
  • [ 4085-31-8 ]
YieldReaction ConditionsOperation in experiment
With sodium carbonate In water at 100℃; for 15h; 2 A mixture of 7-chloro-4-(piperazine-1-yl) quinoline (40 g, 1 equivalent mole), 1,3-dibromopropane (16.15 g, 0.5 equivalent mole), sodium carbonate (20.4 g, 1.2 equivalent mole) in deionised water (400 ml) was heated under reflux for 15 hours at 100° C. The reaction mixture was cooled to room temperature and filtered. The product was washed with deionised water till neutral pH was achieved. The product was again heated in denatured spirit for two hours. Reaction mixture was cooled to room temperature and solid material was filtered and dried at 50-60° C. under vacuum for four to five hours to give 1,3-bis(1-7'-chloro-4-quinolyl-4-piperazinyl)propane (30 g). Yield: 0.8 w/w. Purity (by HPLC): 99.06%
With triethylamine In methanol Heating; Reflux; 7 Example-7: Piperaquine free base.To a mixture of 7-chloro-4-piperazine-l-yl quinoline (100g) in methanol (1000ml) and 1,3-dibromopropane (80g) was added triethyl amine (150g) at 25-30 C. The reaction mass was heated to reflux temperature and stirred for about 24-60 hours. The reaction mixture was cooled to room temperature and filtered the solid. Water (500ml), methanol (500ml) were added to the solid obtained and adjusted the pH to0- 2 with cone. HC1 (300ml). The reaction mass was stirred for about 15 minutes and 10% NaOH solution was added to clear solution to readjust pH of the reaction mixture to 8-13. The precipitated solids were stirred at ambient temperature for about1- 2 hours, and filtered the reaction mass. The crude obtained was stirred in MDC Methanol (1200 ml each) mixture for 15 minutes at ambient temperature. Filtered & evaporated the clear solution obtained up to the formation of product and the solids were precipitated out which was filtered and suction dried to get Piperaquine (85 g, Purity: 99.9 % with all impurities & ROI less than 0.1%) packed in LDPE bag, twisted and tied with plastic fastener. It then inserted in HDPE bag along with one silica gel sachet and one O-buster pack, twisted, and tied with plastic fastener. Both these bags are then put into the outer bag of triple laminated aluminum bag inside black cover and heat-sealed/ twisted and tied with plastic fastener.
  • 3
  • [ 4085-31-8 ]
  • [ 915967-82-7 ]
YieldReaction ConditionsOperation in experiment
With phosphoric acid; water at 5 - 15℃; for 4 - 5h; 3 Preparation of Piperaquine Phosphate EXAMPLE 3 Preparation of Piperaquine Phosphate A suspension of 1,3-bis(1-7'-chloro-4-quinolyl-4-piperazinyl)propane (100 g, 1 equivalent mole) in water (1500 ml) was cooled up to 5-15° C. with stirring. A pre-prepared solution of ortho-phosphoric acid (85 ml, 4.0 equivalent) in water (500 ml) was drop wise added to the suspension during a period of 2 to 3 hours. The solution was allowed to stir for two hour at the same temperature. The solid product was filtered and washed with water (200 ml). The product was dried at 50-55° C. under high vacuum till water content reached 6-8% to obtain the title compound (170 g), m.p. 246-252° C.
  • 4
  • [ 86-98-6 ]
  • [ 4085-31-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: potassium iodide / isopropyl alcohol / 10 h / Reflux; Heating 2: triethylamine / methanol / Heating; Reflux
  • 5
  • [ 4085-31-8 ]
  • [ 85547-56-4 ]
YieldReaction ConditionsOperation in experiment
99.9% With phosphoric acid; water In methanol; dichloromethane for 1 - 2h; 8 Example-8: Piperaquine TetraphosphateTo a stirred clear solution of Piperaquine (100 g 0.19) in methanol and dichloromethane (1000 ml each) there was added activated carbon and stirred for 30 minutes. Carbon was removed from the solution by filtration. The clear solution of 1 Piperaquine in methanol and dichloromethane was cooled to -10 to 30 C and there was added (4-4.5 moles) of Ortho phosphoric acid in water in 60 to 120 minutes. The thick slurry obtained was stirred and then filtered. The filtered crude was washed with (400 ml) of water and dried under vacuum to get the Piperaquine tetra phosphate tetra hydrate ( 180 g 99.9 % with all impurities & ROI less than 0.1) . product is protected from light & The material shall be packed in LDPE bag, twisted and tied with plastic fastener. It then inserted in triple laminated aluminum bag inside black cover along with two silica gel sachets, one molecular sieve and one O-buster pack, and heat sealed under vacuumed nitrogen. Both these bags are then put into the outer bag of triple laminated aluminum bag inside black cover and heat-sealed.These bags are further packed in HDPE drum.
Same Skeleton Products
Historical Records

Similar Product of
[ 4085-31-8 ]

Chemical Structure| 85547-56-4

A821105[ 85547-56-4 ]

1,3-Bis(4-(7-chloroquinolin-4-yl)piperazin-1-yl)propane xphosphate

Reason: Free-salt