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Chemical Structure| 408511-61-5 Chemical Structure| 408511-61-5

Structure of 408511-61-5

Chemical Structure| 408511-61-5

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Product Details of [ 408511-61-5 ]

CAS No. :408511-61-5
Formula : C12H12O2
M.W : 188.22
SMILES Code : O=C(O)C#CC1=C(C)C=C(C)C=C1C

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Application In Synthesis of [ 408511-61-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 408511-61-5 ]

[ 408511-61-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 124-38-9 ]
  • [ 769-26-6 ]
  • [ 408511-61-5 ]
YieldReaction ConditionsOperation in experiment
70% General procedure: This procedure was adapted from Linstadt etal. [25] To a solution of alkyne (13.5mmol) in 40mL of dry THF at-78C was added n-BuLi (13.5mmol). The resulting solution was stirred at-78C for 30min. The reaction mixture was warmed to 0C and the reaction was placed under a balloon of CO2 gas and vigorously stirred for 30min. Then concentrated HCl (10mL), water (10mL) and Et2O (30mL) were added. The aqueous layer was discarded, and the organic layer was extracted with NaOH (1M; 3×20mL). The aqueous extracts were acidified with concentrated HCl, extracted with Et2O (3×20mL), washed with water and brine, dried with anhydrous MgSO4 and concentrated in vacuo. The resulting oil was purified by column chromatography to afford the desired product.
 

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