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Chemical Structure| 421546-91-0 Chemical Structure| 421546-91-0

Structure of 421546-91-0

Chemical Structure| 421546-91-0

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Product Details of [ 421546-91-0 ]

CAS No. :421546-91-0
Formula : C14H22O3
M.W : 238.32
SMILES Code : COCC1=CC(=CC(COC)=C1O)C(C)(C)C
English Name :4-(tert-Butyl)-2,6-bis(methoxymethyl)phenol
MDL No. :MFCD22493465

Safety of [ 421546-91-0 ]

Application In Synthesis of [ 421546-91-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 421546-91-0 ]

[ 421546-91-0 ] Synthesis Path-Downstream   1~6

  • 1
  • [ CAS Unavailable ]
  • [ 105247-74-3 ]
  • [ 421546-91-0 ]
YieldReaction ConditionsOperation in experiment
100% With toluene-4-sulfonic acid at 120℃; for 0.5h; Microwave irradiation;
  • 2
  • [ 98-54-4 ]
  • [ 421546-91-0 ]
  • [ 810-52-6 ]
YieldReaction ConditionsOperation in experiment
72.5% With toluene-4-sulfonic acid In dichloromethane at 110℃; for 0.5h; Microwave irradiation;
  • 3
  • [ 421546-91-0 ]
  • [ 810-52-6 ]
  • [ 60705-62-6 ]
  • [ 78092-53-2 ]
  • [ 68971-82-4 ]
  • [ 81475-22-1 ]
  • [ 84161-29-5 ]
  • [ 190651-92-4 ]
YieldReaction ConditionsOperation in experiment
1: 19% 2: 9% 3: 14% 4: 15% 5: 20% 6: 7% With ferrocenium(III) tetrafluoroborate In dichloromethane at 120℃; for 1h; Microwave irradiation;
  • 4
  • [ 421546-91-0 ]
  • [ 82727-16-0 ]
  • [ 1536481-00-1 ]
YieldReaction ConditionsOperation in experiment
16 g Stage #1: 2,6-bis(methoxymethyl)-para-tert-butylphenol With triethylamine In tetrahydrofuran at 0℃; Stage #2: 1,1,2,2,3,3-hexafluoropropane-1,3-disulfonyl difluoride In tetrahydrofuran at 0℃; for 8h; 1 Synthesis of A-1b After 7.5 g of 2,5-di(methoxymethyl)-4-t-butylphenol was dissolved in 20 mL of tetrahydrofuran and 60 mL of triethylamine was added thereto, temperature was cooled with ice to 0° C. to obtain the reaction solution. Next, the solution in which 10 g of 1,1,2,2,3,3-heptafluoropropane-1,3-disulfonyl fluoride was dissolved in 10 mL of tetrahydrofuran, was added dropwise into the reaction solution and was stirred for 8 hours. 100 mL of ethyl acetate and 100 mL of distilled water were added to the obtained reaction solution and the obtained solution was moved to a separating funnel and the aqueous layer was removed. Thereafter, the organic layer was washed with 200 mL of distilled water for three times, and then the organic layer was condensed to obtain 16 g of a compound (A-1b). 1H-NMR (CDCl3: ppm) δ: 1.33 (9H, s), 3.41 (6H, s), 4.58 (4H, s), 7.50 (2H, s). 19H-NMR (CDCl3: ppm) δ: -118.457 (2F, t, J=15.2 Hz), -113.874 (2F, t, J=15.2 Hz), -108.212 (2F, t, J=15.2 Hz).
  • 5
  • [ 421546-91-0 ]
  • [ CAS Unavailable ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1.1: triethylamine / tetrahydrofuran / 0 °C 1.2: 8 h / 0 °C 2.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C
  • 6
  • [ 421546-91-0 ]
  • [ 1536480-40-6 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1.1: triethylamine / tetrahydrofuran / 0 °C 1.2: 8 h / 0 °C 2.1: sodium hydroxide / tetrahydrofuran; methanol / 20 °C 3.1: methanol / 20 °C
 

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