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Chemical Structure| 423184-29-6 Chemical Structure| 423184-29-6

Structure of 423184-29-6

Chemical Structure| 423184-29-6

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Product Details of [ 423184-29-6 ]

CAS No. :423184-29-6
Formula : C9H8BrFO
M.W : 231.06
SMILES Code : O=C(CC1=CC=C(F)C=C1)CBr

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Application In Synthesis of [ 423184-29-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 423184-29-6 ]

[ 423184-29-6 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 684-93-5 ]
  • [ 459-04-1 ]
  • [ 423184-29-6 ]
YieldReaction ConditionsOperation in experiment
58% (A-126) N,N-Nitrosomethylurea(10.1g, 97.8mmol) was added to 50% potassium hydroxide aqueous solution(40ml)-diethyl ether(250ml), then the yellow ether layer was added to the above-mentioned compound A-125(8.44g, 48.9mmol) in diethyl ether(80ml) under ice cooling.. The mixture was stirred at 0C for 15 minutes and at room temperature for 15 minutes.. The solution was Cooled at -30C, to which was added 48% hydrogen bromide(50ml), then which was stirred at -30C for 30 minutes and at room temperature for 30 minutes.. To the solution was added water, then which was extracted with diethyl ether, washed, dried and evaporated under reduced pressure to give 1-bromo-3-(4-fluorophenyl)propane-2-one(6.52g, yield:58%). NMR(CDCl3)δ:3.91(2H, s), 3.94(2H, s), 7.01-7.07(2H, m), 7.18-7.22(2H, m).
 

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