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Chemical Structure| 42520-90-1 Chemical Structure| 42520-90-1

Structure of 42520-90-1

Chemical Structure| 42520-90-1

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Product Details of [ 42520-90-1 ]

CAS No. :42520-90-1
Formula : C6H4ClNS
M.W : 157.62
SMILES Code : N#CCC1=CC=C(Cl)S1
MDL No. :MFCD09817278

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Application In Synthesis of [ 42520-90-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42520-90-1 ]

[ 42520-90-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 773837-37-9 ]
  • [ 23784-96-5 ]
  • [ 42520-90-1 ]
YieldReaction ConditionsOperation in experiment
With sodium iodide; In water; N,N-dimethyl-formamide; at 20℃; for 2h; A mixture of <strong>[23784-96-5]2-chloro-5-(chloromethyl)thiophen</strong>e (850 mg, 5.09 mmol), sodium cyanide (1.50 g, 30.5 mmol) and sodium iodide (153 mg, 1.02 mmol) in DMF:water (5: 1 ; 24 ml) was stirred at RT for 2h. The reaction was diluted with water and sat. sodium bicarbonate (aq) and extracted with ethyl acetate. The organics were combined and washed with sat. sodium bicarbonate (aq), filtered through an hydrophobic filter and concentrated under reduced pressure. The title compound was used directly in the next step with further purification.
 

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