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Chemical Structure| 4279-74-7 Chemical Structure| 4279-74-7

Structure of 4279-74-7

Chemical Structure| 4279-74-7

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Product Details of [ 4279-74-7 ]

CAS No. :4279-74-7
Formula : C13H12ClNO2S
M.W : 281.75
SMILES Code : CC1=CC=C(C=C1)NS(=O)(C2=CC=C(C=C2)Cl)=O
MDL No. :MFCD00625659

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Application In Synthesis of [ 4279-74-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4279-74-7 ]

[ 4279-74-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 99-99-0 ]
  • [ 14752-66-0 ]
  • [ 4279-74-7 ]
YieldReaction ConditionsOperation in experiment
59% With copper(l) chloride; In 1-methyl-pyrrolidin-2-one; water; at 120℃; for 40h;Inert atmosphere; General procedure: A pressure tube (10 mL) was charged with CuCl (1.0 mg, 0.01 mmol), p-toluenesulfinic acid sodium salt (2a, 107.2 mg, 0.6 mmol), p-methyl nitrobenzene (1a, 27.4 mg, 0.2 mmol) and purged withargon three times. NMP (0.6 mL) and H2O (7.2 L) were added by syringe. The resulting solution was stirred at 120 C for 40 h. After cooling to room temperature, the crude product mixture was diluted with ethylacetate (15 mL) and washed with a saturated solution of NaCl (3 15 mL) and the organic layer was dried over MgSO4 and concentrated under reduced pressure. The resulting residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 6:1) to give 3a as whitesolid; yield: 40.3 mg (77%) (NMR spectra for all compounds shown in Supplementary Materials).
 

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