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Chemical Structure| 42816-53-5 Chemical Structure| 42816-53-5

Structure of 42816-53-5

Chemical Structure| 42816-53-5

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Product Details of [ 42816-53-5 ]

CAS No. :42816-53-5
Formula : C8H6N2O2
M.W : 162.15
SMILES Code : NC1=CC=C2NC(=O)C(=O)C2=C1
MDL No. :MFCD00091972

Safety of [ 42816-53-5 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 42816-53-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 42816-53-5 ]

[ 42816-53-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42816-53-5 ]
  • [ 20876-36-2 ]
YieldReaction ConditionsOperation in experiment
General procedure: The preparation was divided into two steps. Firstly, substituent indoline-2,3-dione (1 equiv) was dissolved in ethanol (10 mL), hydrazine hydrate (2 mL) was added. The reaction mixture was refluxed with magnetic stirring for 3 h and cooled to 0 °C, then sodium hydroxide (3 equiv) was added, refluxed for 0.5 h and cooled to room temperature, then 150 mL water was added. The mixture was acidified by adding 2 N hydrochloric acid to pH 2, and extracted twice with dichloromethane. The organic filtrate was washed twice with brine, dried (Na2SO4), and then concentrated to give corresponding   indolin-2-one by high-vacuum drying. Secondly, a mixture of the corresponding indolin-2-one (1 equiv) and furan-2-carbaldehyde (1 equiv) in ethanol was added two drops of piperidine and refluxed with magnetic stirring for 5 h. After the mixture cooled, the precipitate was filtered, washed with cold ethanol, dried, and recrystallized from methanol to afford the terminal product.
 

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