Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	42971-09-5
Formula :	C₂₂H₂₆N₂O₂
M.W :	350.45
SMILES Code :	O=C(OCC)C1=C[C@@](CCC2)(CC)[C@@](N2CC3)([H])C4=C3C5=CC=CC=C5N41
Synonyms :	Ethyl apovincaminate; Apovincaminic Acid ethyl ester; AY 27255
MDL No. :	MFCD00211233
InChI Key :	DDNCQMVWWZOMLN-IRLDBZIGSA-N
Pubchem ID :	443955

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302
Precautionary Statements:	P280-P305+P351+P338

Primary rat astrocytes	30 µM	12 hours hypoxia/6 hours reoxygenation	Vinpocetine ameliorated oxygen-glucose deprivation/reoxygenation (OGD/R)-induced astrocytic injury via the PI3K/AKT signaling pathway, improving cell viability, reducing LDH release, and decreasing oxidative stress and inflammatory responses.	Front Neurosci. 2020 Apr 2;14:223
Vascular smooth muscle cells (SMCs)	10, 20, 30, 50 µM	16 hours	Vinpocetine dose-dependently inhibited PDGF-stimulated vascular smooth muscle cell migration, as confirmed by two-dimensional migration assays and three-dimensional aortic medial explant invasive assay.	J Pharmacol Exp Ther. 2012 Nov;343(2):479-88
Adult mouse cardiac fibroblasts	10 µM	24 hours	Vinpocetine suppressed TGFβ-induced fibroblast activation and extracellular matrix gene expression	Cardiovasc Drugs Ther. 2017 Apr;31(2):157-166
Vascular smooth muscle cells (SMCs)	25, 50, 75 µM	24 hours	Vinpocetine dose-dependently inhibited vascular smooth muscle cell proliferation, causing G1-phase cell cycle arrest, associated with a decrease in cyclin D1 and an increase in p27Kip1 levels.	J Pharmacol Exp Ther. 2012 Nov;343(2):479-88
BV2 cells	20 µM	24 hours	Vinpocetine inhibits OGD-induced M1 phenotype and promotes M2 phenotype in BV2 cells	Front Cell Dev Biol. 2021 Feb 4;8:616590
MRC-5 cell line	100, 50, 25, 12.5, 6.25 mcg/mL	24-48 hours	To assess the cytotoxicity of vinpocetine on the MRC-5 cell line, results showed that vinpocetine exhibited low cytotoxicity against MRC-5 cells with an IC50 of 289.2 µg/ml.	Sci Rep. 2024 May 15;14(1):11131
Mouse resident peritoneal macrophages	30 µM	30 minutes or 6 hours	Vinpocetine suppressed TNF-α-induced p65 nuclear translocation and proinflammatory mediator expression	Clin Sci (Lond). 2020 Nov 27;134(22):2959-2976
MRC-5 cell line	100 µg/mL	48 hours	Vinpocetine significantly reduced the expression of fibrotic genes (fibronectin, vimentin, α-SMA, and Smad2/3) induced by TGF-β1, indicating its anti-fibrotic effect by interfering with the TGF-β1/Smad signaling pathway.	Sci Rep. 2024 May 15;14(1):11131
Human middle ear epithelial cells (HMEEC)	10 µM	6 hours	Vinpocetine inhibited S. pneumoniae-induced upregulation of pro-inflammatory mediators (IL-1β, IL-6, IL-8, and TNF-α) mRNA expression	J Immunol. 2020 Feb 15;204(4):933-942
Macrophage RAW264.7 cells	50 µM	60 min pretreatment followed by 6 hours	Vinpocetine potently inhibited TNF-α–induced NF-κB–dependent transcriptional activity	Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800
Human lung epithelial A549 cells	50 µM	60 min pretreatment followed by 6 hours	Vinpocetine potently inhibited TNF-α–induced NF-κB–dependent transcriptional activity	Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800
Human umbilical vein endothelial cells (HUVECs)	50 µM	60 min pretreatment followed by 6 hours	Vinpocetine potently inhibited TNF-α–induced NF-κB–dependent transcriptional activity	Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800
Vascular smooth muscle cells (VSMCs)	50 µM	60 min pretreatment followed by 6 hours	Vinpocetine potently inhibited TNF-α–induced NF-κB–dependent transcriptional activity	Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800
Adult mouse cardiomyocytes	10-40 µM	72 hours	Vinpocetine dose-dependently suppressed Ang II-stimulated myocyte hypertrophic growth	Cardiovasc Drugs Ther. 2017 Apr;31(2):157-166
ARPE19/NF-κB-luciferase reporter cells	50 µM	8 hours	To evaluate the inhibitory effect of vinpocetine on Aβ-induced NF-κB activation. Results showed that vinpocetine significantly suppressed Aβ-induced NF-κB activation, reducing it to a level comparable to the control group.	Exp Eye Res. 2014 Oct;127:49-58

Wistar rats	High-fructose diet-induced metabolic syndrome model	Tube feeding	1 mg/kg	From the ninth week, lasting for 12 weeks	To investigate the ameliorative effect of Vinpocetine on metabolic syndrome-associated bladder overactivity, results showed that Vinpocetine restored the contraction and relaxation responses of bladder detrusor muscle and exerted anti-inflammatory effects.	Biomedicines. 2022 Oct 26;10(11):2716
Sprague Dawley rats	High-fat diet (HFD) and diabetes-induced fatty liver model	Oral	10 and 20 mg/kg/day	Once daily for 8 weeks	Vinpo dose-dependently mitigated the HFD-induced rise in serum ALT, AST, and ALP activities and improved the hepatic architecture of steatotic rats, especially at a dose of 20 mg/kg. The findings elucidated the mechanisms behind Vinpo's beneficial effects, including insulin sensitivity improvement, attenuation of oxidative stress, and dampening of the sterile inflammatory response. The concomitant administration of Lactobacillus spp. probiotics with Vinpo significantly enhanced these effects.	AMB Express. 2024 Aug 2;14(1):89
Wistar rats	Middle cerebral artery occlusion (MCAO) model	Intraperitoneal injection	10 mg/kg	Single dose, 30 min before MCAO	Vinpocetine activated the PI3K/AKT signaling pathway to enhance phosphorylation of astrocytic connexin 43 (Cx43), thereby attenuating cerebral ischemia/reperfusion injury, reducing cerebral infarction volume and edema, and decreasing oxidative stress, inflammation, and apoptosis.	Front Neurosci. 2020 Apr 2;14:223
Mice (C57BL/6)	S. pneumoniae-induced otitis media model	Intraperitoneal injection	10 mg/kg	Post-infection treatment at 2 hours, continued for 3 days	Vinpocetine significantly suppressed S. pneumoniae-induced middle ear inflammation, including upregulation of inflammatory mediators, mucosal thickening, and neutrophil infiltration	J Immunol. 2020 Feb 15;204(4):933-942
Female Wistar albino rats	Estradiol-benzoate induced cervical hyperkeratosis model	Oral	10 mg/kg/day	Once daily for 4 weeks	Vinpocetine significantly alleviated all biochemical and histopathological abnormalities induced by EB, mitigating cervical hyperkeratosis via NLRP3-induced pyroptosis and activation of the SIRT1/Nrf2 signaling pathway.	Sci Rep. 2024 Aug 19;14(1):19171
Adult Long-Evans rats	Aβ-induced retinal inflammation model	Intraperitoneal injection	15 mg/kg	Once daily for four days	To evaluate the inhibitory effect of vinpocetine on Aβ-induced NF-κB nuclear translocation and inflammatory responses. Results showed that vinpocetine significantly inhibited NF-κB nuclear translocation and reduced the expression and activation of NLRP3, caspase-1, IL-1β, IL-18, and TNF-α.	Exp Eye Res. 2014 Oct;127:49-58
Mice	LPS- or TNF-α-induced lung inflammation model	Intraperitoneal injection	2.5, 5, 10 mg/kg	Single dose, lasting 6 h	Vinpocetine dose-dependently inhibited LPS- or TNF-α-induced inflammatory mediator expression and neutrophil infiltration	Proc Natl Acad Sci U S A. 2010 May 25;107(21):9795-800
Male albino rats	Aluminum-induced Alzheimer's disease model	Oral	20 mg/kg	Daily for five weeks	Vinpocetine in combination with cocoa significantly improved cognitive function and behavioral performance in the aluminum-induced Alzheimer's disease model, reduced oxidative stress and inflammation, and modulated the Wnt/β-catenin/GSK-3β/Nrf2/HO-1 and PERK/CHOP/Bcl-2 pathways.	Pharmaceutics. 2023 Jul 31;15(8):2063
BALB/c male mice	Bleomycin-induced pulmonary fibrosis model	Oral	20 mg/kg/day	Once daily from day 7 of induction till the end of the experiment (day 21)	Vinpocetine significantly alleviated bleomycin-induced fibrotic endpoints, including reduced expression of fibrotic-related proteins, oxidative stress, and inflammatory mediators, and exerted anti-fibrotic effects by upregulating Nrf2 and PPAR-γ expression and downregulating the NLRP3/NF-κB pathway.	Sci Rep. 2024 May 15;14(1):11131
Wistar rats	Adenine-induced chronic kidney disease model	Oral	20 mg/kg/day	Daily administration for 4 weeks	Vinpocetine ameliorated adenine-induced renal fibrosis and epithelial-mesenchymal transition by targeting the DNMT1/Klotho/β-catenin/Snail1 and MMP-7 pathways	Naunyn Schmiedebergs Arch Pharmacol. 2025 Mar;398(3):2769-2781
C57BL/6J male mice	Ang II-induced cardiac hypertrophy and fibrosis model	Intraperitoneal injection	5 mg/kg/day	Once daily for 17 days (3 days prior and 14 days during Ang II infusion)	Vinpocetine significantly attenuated Ang II-induced cardiac hypertrophy and fibrosis	Cardiovasc Drugs Ther. 2017 Apr;31(2):157-166
FVB/NJ mice	Carotid artery ligation injury model	Intraperitoneal injection	5 mg/kg/day	Once daily for 14 days	Vinpocetine significantly reduced neointimal formation after carotid artery ligation injury and decreased spontaneous remodeling of human saphenous vein explants.	J Pharmacol Exp Ther. 2012 Nov;343(2):479-88
C57BL/6J mice	Abdominal aortic aneurysm model	Intraperitoneal injection	5mg/kg	Daily for 28 days	Vinpocetine remarkably attenuated aneurysmal dilation, improved elastin degradation, smooth muscle cell depletion, collagen fibers remodeling and macrophage infiltration	Clin Sci (Lond). 2020 Nov 27;134(22):2959-2976

{[proInfo.proName]}

CAS No.: 42971-09-5

{[proInfo.proName]}

CAS No.: 42971-09-5

Alternative Products

Product Details of Vinpocetine

Safety of Vinpocetine

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

NCT00719953	-		Completed	-	-
NCT00719953	Elderly Memor... More >>y Impairment Less <<	Phase 4	Completed	-	Israel ... More >> Suorasky Medical Center Tel-Aviv, Israel Less <<
NCT01515839	Traumatic Brain Injury	Not Applicable	Completed	-	United States, California ... More >> Amen Clinics, Inc. Newport Beach, California, United States, 92660 Less <<
NCT02857829	Biomedical Enhancement	Not Applicable	Completed	-	Netherlands ... More >> Maastricht University Maastricht, Netherlands Less <<
NCT02011971	Epilepsy	PHASE1\|PHASE2	SUSPENDED	2025-12-26	Stanford University, Palo Alto... More >>, California, 94304, United States Less <<
NCT01400035	-		Completed	-	China ... More >> Weiwei Zhang Beijing, China, 100700 Less <<
NCT02878772	Stroke Immuno... More >>regulation Inflammation Vinpocetine Less <<	Phase 2 Phase 3	Completed	-	-
NCT06635746	Fetal Alcohol Spectrum Disorde... More >>rs Less <<	PHASE1	NOT_YET_RECRUITING	2026-06-01	-

Bio Calculators
Preparing Stock Solutions		1mg	5mg	10mg
Preparing Stock Solutions	1 mM 5 mM 10 mM	2.85mL 0.57mL 0.29mL	14.27mL 2.85mL 1.43mL	28.53mL 5.71mL 2.85mL
Dissolving Methods	Animal experiment Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn: in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day; The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound. Protocol 1 Protocol 2

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed