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Chemical Structure| 43187-67-3 Chemical Structure| 43187-67-3

Structure of 43187-67-3

Chemical Structure| 43187-67-3

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Product Details of [ 43187-67-3 ]

CAS No. :43187-67-3
Formula : C9H9ClO
M.W : 168.62
SMILES Code : OC1(C2=CC=CC(Cl)=C2)CC1

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Application In Synthesis of [ 43187-67-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 43187-67-3 ]

[ 43187-67-3 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 75-11-6 ]
  • [ 2905-65-9 ]
  • [ 43187-67-3 ]
YieldReaction ConditionsOperation in experiment
Example 146; 5-[1-(3-Chlorophenyl)cyclopropoxy]quinazoline-2,4-diamine; [00409] Step 1; A solution of <strong>[2905-65-9]methyl 3-chlorobenzoate</strong> (0.27 g, 1.58 mmol) and diiodomethane) in anhydrous tetrahydrofuran was added slowly to a vigorously stirred and heated (50 C) slurry of samarium powder (1.0 g, 6.65 mmol) in tetrahydrofuran over 1.5 hours. After complete addition, the reaction mixture was stirred for 1 hour, than cooled (-10 C), quenched with 1 N hydrochloric acid over 30 min. The reaction mixture was extracted with ether, dried, filtered and concentrated. Purification by silica gel chromatography (1:1 hexanes in dichloromethane) afford 100 mg of 1-(3- chlorophenyl) cyclopropanol.
 

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