Structure of Fenbendazole
CAS No.: 43210-67-9
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.
Synonyms: Methyl 5-(phenylthio)-2-benzimidazolecarbamate
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Batch number can be found on the product's label following the word 'Batch'.
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CAS No. : | 43210-67-9 |
Formula : | C15H13N3O2S |
M.W : | 299.35 |
SMILES Code : | O=C(OC)NC1=NC2=CC=C(SC3=CC=CC=C3)C=C2N1 |
Synonyms : |
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
|
MDL No. : | MFCD00144301 |
InChI Key : | HDDSHPAODJUKPD-UHFFFAOYSA-N |
Pubchem ID : | 3334 |
GHS Pictogram: |
![]() ![]() |
Signal Word: | Danger |
Hazard Statements: | H361-H373-H410 |
Precautionary Statements: | P201-P202-P260-P273-P280-P308+P313-P391-P405-P501 |
Class: | 9 |
UN#: | 3077 |
Packing Group: | Ⅲ |
In Vitro:
Concentration | Treated Time | Description | References |
Soybean seedlings | 10 µM | 1 week | To study the absorption and metabolism of fenbendazole in soybean seedlings, it was found that fenbendazole was extensively metabolized, with sixteen metabolites identified. | Int J Mol Sci. 2021 Jun 22;22(13):6647 |
human embryonic lung fibroblast IMR-90 cells | 0.2 μM, 0.5 μM | 48 hours | To assess the effect of FBZ on fibroblast viability and proliferation, results showed FBZ inhibited fibroblast vitality in a concentration- and time-dependent manner. | Int J Mol Sci. 2022 Nov 15;23(22):14088 |
In Vivo:
Administration | Dosage | Frequency | Description | References |
Soybean (Glycine max) | Greenhouse cultivation | Irrigation | 10 µM | 3 times per week for 2, 4, and 6 weeks | To study the absorption, translocation, and metabolism of fenbendazole in soybean plants, it was found that fenbendazole was absorbed and translocated to leaves, pods, and beans, and fenbendazole and its metabolites were detected in beans. | Int J Mol Sci. 2021 Jun 22;22(13):6647 |
Male wild-type C57BL/6 mice | Bleomycin-induced pulmonary fibrosis model | Oral | 150 ppm FBZ | From day 10 post bleomycin challenge for additional 10 days | To evaluate the effect of FBZ on bleomycin-induced pulmonary fibrosis, results showed FBZ attenuated lung fibrosis, as evidenced by preserved lung architecture and decreased ECM deposition. | Int J Mol Sci. 2022 Nov 15;23(22):14088 |
Clinical Trial:
NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
NCT02234570 | Neurocysticercosis | Phase 1 | Completed | - | United States, Iowa ... More >> University of Iowa - Vaccine Research and Education Unit Iowa City, Iowa, United States, 52242-2600 Less << |
NCT03466710 | Cervical Cancer Screening | Not Applicable | Completed | - | - |
NCT03104257 | - | Recruiting | July 2021 | United States, Connecticut ... More >> Conneticut Mental Health Center Recruiting New Haven, Connecticut, United States, 06519 Contact 203-974-7775 Contact 203-974-7489 Principal Investigator: Patrick Skosnik, PhD Principal Investigator: Mohini Ranganathan, MD Less << | |
NCT02032641 | Scar | Not Applicable | Completed | - | United States, Florida ... More >> Bascom Palmer Eye Institute Miami, Florida, United States, 33136 Bascom Palmer Eye Institute Plantation, Florida, United States, 33324 Less << |
NCT03261700 | Intimate Partner Violence ... More >> Empowerment Less << | Phase 1 | Recruiting | September 30, 2020 | United States, Massachusetts ... More >> VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA Recruiting Boston, Massachusetts, United States, 02130 Contact: Katherine M Iverson, PhD MA BA 857-364-2066 Katherine.Iverson@va.gov Contact: Mary Driscoll, PhD (203) 932-5744 ext 3631 Mary.Driscoll3@va.gov Principal Investigator: Katherine M. Iverson, PhD MA BA Less << |
NCT03206307 | - | Active, not recruiting | December 30, 2018 | Germany ... More >> Jacobs University Bremen gGmbH Bremen, Germany, 28759 Less << | |
NCT02032641 | - | Completed | - | - | |
NCT01720030 | Acute Kidney Injury | Phase 2 Phase 3 | Unknown | October 2017 | Netherlands ... More >> VieCuri Medical Center Venlo, Limburg, Netherlands, NL-5912 BL Less << |
NCT01844024 | Pregnancy | Phase 4 | Completed | - | Uganda ... More >> Mulago Hospital Kampala, Uganda Less << |
NCT03260647 | - | Recruiting | August 1, 2021 | Canada, Ontario ... More >> Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada Contact: Amit Oza 416-946-2818 amit.oza@uhn.ca Contact: Liesa Baumann 416-946-4501 ext 5889 liesa.baumann@uhn.ca Principal Investigator: Stephanie Lheureux, Dr Less << | |
NCT01050881 | - | Unknown | October 2010 | United Kingdom ... More >> NHS Blood and Transplant, Transfusion Microbiology Not yet recruiting Colindale, London, United Kingdom, NW9 5BG Contact: Cameron F Paige, MSc +44 (0)208 271 6329 cameron.paige@nhsbt.nhs.uk Contact: Patricia E Hewitt, FRCP FRCPath 020 8271 6331 patricia.hewitt@nhsbt.nhs.uk Principal Investigator: Patricia E Hewitt, FRCP FRCPath Less << | |
NCT03109366 | Chronic Illness | Not Applicable | Completed | - | Norway ... More >> Oslo University Hospital, Rikshospitalet, Oslo, Norway Less << |
NCT01743508 | Incomplete Abortion | Not Applicable | Completed | - | Uganda ... More >> Mulago Hospital Kampala, Uganda Less << |
NCT02937194 | Dental Caries | Not Applicable | Recruiting | December 2019 | China ... More >> The University of Hong Kong Recruiting Hong Kong, China Contact: May Chun Mei WONG, BSocSc, MPhil, PhD +(852) 28590422 mcmwong@hku.hk Less << |
NCT01417884 | - | Recruiting | December 2025 | Germany ... More >> Medizinische Klinik und Poliklinik Tübingen, Cardiology Department, University Hospital Tübingen Recruiting Tübingen, Baden Wuerttemberg, Germany, 72076 Less << | |
NCT00139100 | Lymphedema Ce... More >>llulitis Less << | Not Applicable | Completed | - | Haiti ... More >> Hopital Ste. Croix Leogane, Haiti Less << |
NCT02284204 | Dental Anxiety | Phase 2 | Completed | - | Brazil ... More >> Faculty of Dentistry Goiania, Goias, Brazil Less << |
NCT02923882 | Pregnant Women ... More >> Low-Birth-Weight Infant Less << | Phase 2 | Completed | - | - |
NCT02218151 | Blood Disorders | Not Applicable | Recruiting | August 2020 | United States, North Carolina ... More >> Duke University Adult Bone Marrow Transplant Clinic Recruiting Durham, North Carolina, United States, 27705 Contact: Krista Rowe, RN 919-684-7115 krista.rowe@duke.edu Contact: Jennifer Loftis, RN 919-668-1939 jennifer.loftis@duke.edu Principal Investigator: Nelson J Chao, MD, MBA Sub-Investigator: Anthony D Sung, MD Less << |
NCT00102076 | - | Completed | - | United States, Maryland ... More >> National Institutes of Health Clinical Center (CC) Bethesda, Maryland, United States, 20892 Less << | |
NCT01204502 | Haploidentical Stem Cell Trans... More >>plantation Less << | Phase 1 Phase 2 | Terminated(Changes in the clin... More >>ical practice) Less << | - | United Kingdom ... More >> Great Ormond Street Hospital for Children NHS Trust London, United Kingdom, WC1N 3JH Less << |
NCT02324868 | Cystic Fibrosis ... More >> Pulmonary Hypertension Neoplasms Less << | Not Applicable | Terminated(logistic problems) | - | Belgium ... More >> University Hospitals Leuven Leuven, Belgium, 3000 Less << |
NCT02642250 | Chronic Diarrhea | Phase 2 Phase 3 | Completed | - | Pakistan ... More >> Shifa Ul MUlk Memorial Hospital Karachi, Pakistan Less << |
NCT00000300 | Opioid-Related Disorders | Phase 4 | Completed | - | United States, California ... More >> Friends Research Institute Los Angeles, California, United States, 90025 Less << |
NCT03035760 | Helminthic Infection | Phase 1 | Active, not recruiting | December 1, 2018 | United States, Iowa ... More >> University of Iowa - Vaccine Research and Education Unit Iowa City, Iowa, United States, 52242-2600 Less << |
NCT00355693 | Oral Surgical Procedures ... More >> Surgery, Oral Dental Anxiety Surgery Colonoscopy Less << | Phase 4 | Unknown | - | United Kingdom ... More >> Duncan Street Dental Centre Not yet recruiting Edinburgh, United Kingdom, EH9 1SR Contact: Avril Macpherson, BDS, MFDS RCSEd, MSND RCSEd +44131 667 7114 avril.macpherson@lpct.scot.nhs.uk Contact: Francis Arnstein, MB ChB, FRCA +44131 667 7114 arnie.arnstein@luht.scot.nhs.uk Principal Investigator: Avril Macpherson, MFDS MSND Sub-Investigator: Francis Arnstein, MB ChB, FRCA Glasgow Dental Hospital and School Not yet recruiting Glasgow, United Kingdom, G2 3JZ Contact: Conor P O'Brien, BDS FDS 0141 211 9768 ext 9768 Conor.O'Brien@NorthGlasgow.SCOT.NHS.UK Contact: Sonia Allam, MB ChB FRCA 0141 211 4625 soniaallam@yahoo.com Principal Investigator: Conor P O'Brien, BDS FDS Less << |
NCT02449356 | Mechanical Ventilation Complic... More >>ation Less << | Not Applicable | Completed | - | China, Hunan ... More >> Wangyuan Zou Changsha, Hunan, China, 410013 Less << |
NCT02449356 | - | Completed | - | - | |
NCT03734718 | Diabetes Mellitus, Type 1 ... More >> Hypoglycemia Less << | Not Applicable | Recruiting | June 1, 2019 | Denmark ... More >> Steno Diabetes Center CopenhagenSteno Diabetes Center Copenhagen, Clinical Metabolic Physiology Recruiting Hellerup, Denmark, 2800 Contact: Sebastian M heimbürger, Msc. +45 38673407 sebastian.moeller.heimbuerger@regionh.dk Contact: Filip K Knop, Prof, MD Principal Investigator: Filip K Knop, Prof, MD Less << |
NCT02666274 | - | Unknown | June 2017 | United Kingdom ... More >> Guy's and St Thomas' NHS Foundation Trust Recruiting London, United Kingdom, SE1 7EH Contact: Olga Tosas, PhD +442071888163 olga.tosas@gstt.nhs.uk Less << | |
NCT00255840 | HIV Infections | Not Applicable | Completed | - | - |
NCT00255840 | - | Completed | - | - | |
NCT00321360 | Healthy | Phase 4 | Completed | - | United Kingdom ... More >> Glasgow Dental Hospital Glasgow, Strathclyde, United Kingdom Less << |
NCT00080522 | HIV Infections | Not Applicable | Completed | - | South Africa ... More >> University of the Witwatersrand/Clinical HIV Research Unit Johannesburg, Gauteng, South Africa, 2013 University of Cape Town/Masiphumelele Cape Town, South Peninsula, South Africa, 8005 Less << |
NCT00967525 | Acute Myeloid Leukemia ... More >> Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Myelodysplastic Syndrome Less << | Not Applicable | Terminated(poor enrollment) | - | United States, Georgia ... More >> Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 Emory University Atlanta, Georgia, United States, 30322 Less << |
NCT01744236 | Type 2 Diabetes | Phase 4 | Completed | - | Netherlands ... More >> VU University Medical Center Amsterdam, Netherlands, 1081HV Less << |
NCT02890784 | Myeloid Leukemia, Chronic | Phase 3 | Recruiting | December 2021 | - |
NCT02856178 | Pulmonary Aspergillosis - Inva... More >>sive Acute Myeloid Leukemia Less << | Phase 1 Phase 2 | Withdrawn(study no longer requ... More >>ired) Less << | - | - |
NCT01628055 | Ischemic Stroke | Phase 1 | Withdrawn(difficult recruitmen... More >>t and new black box warning for IVIG) Less << | - | United States, Virginia ... More >> Inova Health Systems; Inova Fairfax Hospital Falls Church, Virginia, United States, 22042 Less << |
NCT03556098 | Diabetes Mellitus, Type 1 | Not Applicable | Recruiting | January 1, 2020 | Denmark ... More >> Steno Diabetes Center Copenhagen, Clinical Metabolic Physiology Recruiting Hellerup, Denmark, 2900 Contact: Bjørn Hoe, MD 004553634340 bjoern.hoe@regionh.dk Contact: Filip K Knop, PhD, MD filip.krag.knop.01@regionh.dk Less << |
NCT03038126 | Safety Issues ... More >> Chronic Kidney Disease Less << | Not Applicable | Completed | - | United States, Maryland ... More >> Baltimore VA Medical Center Baltimore, Maryland, United States, 21201 Less << |
NCT00516945 | Hepatitis B N... More >>eoplasms Less << | Not Applicable | Completed | - | China ... More >> Queen Elizabeth Hospital Hong Kong, China Less << |
NCT02092597 | Type 2 Diabetes Mellitus | Phase 4 | Completed | - | Czechia ... More >> General University Hospital Prague, Czechia, 128 08 Less << |
NCT02521155 | Gingivitis De... More >>ntal Plaque Less << | Not Applicable | Completed | - | Canada, Quebec ... More >> Faculty of Dental medicine Montreal, Quebec, Canada, H3C3J7 Less << |
Bio Calculators | ||||
Preparing Stock Solutions | ![]() |
1mg | 5mg | 10mg |
1 mM 5 mM 10 mM |
3.34mL 0.67mL 0.33mL |
16.70mL 3.34mL 1.67mL |
33.41mL 6.68mL 3.34mL |