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Chemical Structure| 43210-67-9 Chemical Structure| 43210-67-9

Structure of Fenbendazole
CAS No.: 43210-67-9

Chemical Structure| 43210-67-9

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Fenbendazole is a broad spectrum benzimidazole anthelmintic used against gastrointestinal parasites.

Synonyms: Methyl 5-(phenylthio)-2-benzimidazolecarbamate

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Product Details of Fenbendazole

CAS No. :43210-67-9
Formula : C15H13N3O2S
M.W : 299.35
SMILES Code : O=C(OC)NC1=NC2=CC=C(SC3=CC=CC=C3)C=C2N1
Synonyms :
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
MDL No. :MFCD00144301
InChI Key :HDDSHPAODJUKPD-UHFFFAOYSA-N
Pubchem ID :3334

Safety of Fenbendazole

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H361-H373-H410
Precautionary Statements:P201-P202-P260-P273-P280-P308+P313-P391-P405-P501
Class:9
UN#:3077
Packing Group:

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
Soybean seedlings 10 µM 1 week To study the absorption and metabolism of fenbendazole in soybean seedlings, it was found that fenbendazole was extensively metabolized, with sixteen metabolites identified. Int J Mol Sci. 2021 Jun 22;22(13):6647
human embryonic lung fibroblast IMR-90 cells 0.2 μM, 0.5 μM 48 hours To assess the effect of FBZ on fibroblast viability and proliferation, results showed FBZ inhibited fibroblast vitality in a concentration- and time-dependent manner. Int J Mol Sci. 2022 Nov 15;23(22):14088

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Soybean (Glycine max) Greenhouse cultivation Irrigation 10 µM 3 times per week for 2, 4, and 6 weeks To study the absorption, translocation, and metabolism of fenbendazole in soybean plants, it was found that fenbendazole was absorbed and translocated to leaves, pods, and beans, and fenbendazole and its metabolites were detected in beans. Int J Mol Sci. 2021 Jun 22;22(13):6647
Male wild-type C57BL/6 mice Bleomycin-induced pulmonary fibrosis model Oral 150 ppm FBZ From day 10 post bleomycin challenge for additional 10 days To evaluate the effect of FBZ on bleomycin-induced pulmonary fibrosis, results showed FBZ attenuated lung fibrosis, as evidenced by preserved lung architecture and decreased ECM deposition. Int J Mol Sci. 2022 Nov 15;23(22):14088

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT02234570 Neurocysticercosis Phase 1 Completed - United States, Iowa ... More >> University of Iowa - Vaccine Research and Education Unit Iowa City, Iowa, United States, 52242-2600 Less <<
NCT03466710 Cervical Cancer Screening Not Applicable Completed - -
NCT03104257 - Recruiting July 2021 United States, Connecticut ... More >> Conneticut Mental Health Center Recruiting New Haven, Connecticut, United States, 06519 Contact    203-974-7775       Contact    203-974-7489       Principal Investigator: Patrick Skosnik, PhD          Principal Investigator: Mohini Ranganathan, MD Less <<
NCT02032641 Scar Not Applicable Completed - United States, Florida ... More >> Bascom Palmer Eye Institute Miami, Florida, United States, 33136 Bascom Palmer Eye Institute Plantation, Florida, United States, 33324 Less <<
NCT03261700 Intimate Partner Violence ... More >> Empowerment Less << Phase 1 Recruiting September 30, 2020 United States, Massachusetts ... More >> VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA Recruiting Boston, Massachusetts, United States, 02130 Contact: Katherine M Iverson, PhD MA BA    857-364-2066    Katherine.Iverson@va.gov    Contact: Mary Driscoll, PhD    (203) 932-5744 ext 3631    Mary.Driscoll3@va.gov    Principal Investigator: Katherine M. Iverson, PhD MA BA Less <<
NCT03206307 - Active, not recruiting December 30, 2018 Germany ... More >> Jacobs University Bremen gGmbH Bremen, Germany, 28759 Less <<
NCT02032641 - Completed - -
NCT01720030 Acute Kidney Injury Phase 2 Phase 3 Unknown October 2017 Netherlands ... More >> VieCuri Medical Center Venlo, Limburg, Netherlands, NL-5912 BL Less <<
NCT01844024 Pregnancy Phase 4 Completed - Uganda ... More >> Mulago Hospital Kampala, Uganda Less <<
NCT03260647 - Recruiting August 1, 2021 Canada, Ontario ... More >> Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada Contact: Amit Oza    416-946-2818    amit.oza@uhn.ca    Contact: Liesa Baumann    416-946-4501 ext 5889    liesa.baumann@uhn.ca    Principal Investigator: Stephanie Lheureux, Dr Less <<
NCT01050881 - Unknown October 2010 United Kingdom ... More >> NHS Blood and Transplant, Transfusion Microbiology Not yet recruiting Colindale, London, United Kingdom, NW9 5BG Contact: Cameron F Paige, MSc    +44 (0)208 271 6329    cameron.paige@nhsbt.nhs.uk    Contact: Patricia E Hewitt, FRCP FRCPath    020 8271 6331    patricia.hewitt@nhsbt.nhs.uk    Principal Investigator: Patricia E Hewitt, FRCP FRCPath Less <<
NCT03109366 Chronic Illness Not Applicable Completed - Norway ... More >> Oslo University Hospital, Rikshospitalet, Oslo, Norway Less <<
NCT01743508 Incomplete Abortion Not Applicable Completed - Uganda ... More >> Mulago Hospital Kampala, Uganda Less <<
NCT02937194 Dental Caries Not Applicable Recruiting December 2019 China ... More >> The University of Hong Kong Recruiting Hong Kong, China Contact: May Chun Mei WONG, BSocSc, MPhil, PhD    +(852) 28590422    mcmwong@hku.hk Less <<
NCT01417884 - Recruiting December 2025 Germany ... More >> Medizinische Klinik und Poliklinik Tübingen, Cardiology Department, University Hospital Tübingen Recruiting Tübingen, Baden Wuerttemberg, Germany, 72076 Less <<
NCT00139100 Lymphedema Ce... More >>llulitis Less << Not Applicable Completed - Haiti ... More >> Hopital Ste. Croix Leogane, Haiti Less <<
NCT02284204 Dental Anxiety Phase 2 Completed - Brazil ... More >> Faculty of Dentistry Goiania, Goias, Brazil Less <<
NCT02923882 Pregnant Women ... More >> Low-Birth-Weight Infant Less << Phase 2 Completed - -
NCT02218151 Blood Disorders Not Applicable Recruiting August 2020 United States, North Carolina ... More >> Duke University Adult Bone Marrow Transplant Clinic Recruiting Durham, North Carolina, United States, 27705 Contact: Krista Rowe, RN    919-684-7115    krista.rowe@duke.edu    Contact: Jennifer Loftis, RN    919-668-1939    jennifer.loftis@duke.edu    Principal Investigator: Nelson J Chao, MD, MBA          Sub-Investigator: Anthony D Sung, MD Less <<
NCT00102076 - Completed - United States, Maryland ... More >> National Institutes of Health Clinical Center (CC) Bethesda, Maryland, United States, 20892 Less <<
NCT01204502 Haploidentical Stem Cell Trans... More >>plantation Less << Phase 1 Phase 2 Terminated(Changes in the clin... More >>ical practice) Less << - United Kingdom ... More >> Great Ormond Street Hospital for Children NHS Trust London, United Kingdom, WC1N 3JH Less <<
NCT02324868 Cystic Fibrosis ... More >> Pulmonary Hypertension Neoplasms Less << Not Applicable Terminated(logistic problems) - Belgium ... More >> University Hospitals Leuven Leuven, Belgium, 3000 Less <<
NCT02642250 Chronic Diarrhea Phase 2 Phase 3 Completed - Pakistan ... More >> Shifa Ul MUlk Memorial Hospital Karachi, Pakistan Less <<
NCT00000300 Opioid-Related Disorders Phase 4 Completed - United States, California ... More >> Friends Research Institute Los Angeles, California, United States, 90025 Less <<
NCT03035760 Helminthic Infection Phase 1 Active, not recruiting December 1, 2018 United States, Iowa ... More >> University of Iowa - Vaccine Research and Education Unit Iowa City, Iowa, United States, 52242-2600 Less <<
NCT00355693 Oral Surgical Procedures ... More >> Surgery, Oral Dental Anxiety Surgery Colonoscopy Less << Phase 4 Unknown - United Kingdom ... More >> Duncan Street Dental Centre Not yet recruiting Edinburgh, United Kingdom, EH9 1SR Contact: Avril Macpherson, BDS, MFDS RCSEd, MSND RCSEd    +44131 667 7114    avril.macpherson@lpct.scot.nhs.uk    Contact: Francis Arnstein, MB ChB, FRCA    +44131 667 7114    arnie.arnstein@luht.scot.nhs.uk    Principal Investigator: Avril Macpherson, MFDS MSND          Sub-Investigator: Francis Arnstein, MB ChB, FRCA          Glasgow Dental Hospital and School Not yet recruiting Glasgow, United Kingdom, G2 3JZ Contact: Conor P O'Brien, BDS FDS    0141 211 9768 ext 9768    Conor.O'Brien@NorthGlasgow.SCOT.NHS.UK    Contact: Sonia Allam, MB ChB FRCA    0141 211 4625    soniaallam@yahoo.com    Principal Investigator: Conor P O'Brien, BDS FDS Less <<
NCT02449356 Mechanical Ventilation Complic... More >>ation Less << Not Applicable Completed - China, Hunan ... More >> Wangyuan Zou Changsha, Hunan, China, 410013 Less <<
NCT02449356 - Completed - -
NCT03734718 Diabetes Mellitus, Type 1 ... More >> Hypoglycemia Less << Not Applicable Recruiting June 1, 2019 Denmark ... More >> Steno Diabetes Center CopenhagenSteno Diabetes Center Copenhagen, Clinical Metabolic Physiology Recruiting Hellerup, Denmark, 2800 Contact: Sebastian M heimbürger, Msc.    +45 38673407    sebastian.moeller.heimbuerger@regionh.dk    Contact: Filip K Knop, Prof, MD          Principal Investigator: Filip K Knop, Prof, MD Less <<
NCT02666274 - Unknown June 2017 United Kingdom ... More >> Guy's and St Thomas' NHS Foundation Trust Recruiting London, United Kingdom, SE1 7EH Contact: Olga Tosas, PhD    +442071888163    olga.tosas@gstt.nhs.uk Less <<
NCT00255840 HIV Infections Not Applicable Completed - -
NCT00255840 - Completed - -
NCT00321360 Healthy Phase 4 Completed - United Kingdom ... More >> Glasgow Dental Hospital Glasgow, Strathclyde, United Kingdom Less <<
NCT00080522 HIV Infections Not Applicable Completed - South Africa ... More >> University of the Witwatersrand/Clinical HIV Research Unit Johannesburg, Gauteng, South Africa, 2013 University of Cape Town/Masiphumelele Cape Town, South Peninsula, South Africa, 8005 Less <<
NCT00967525 Acute Myeloid Leukemia ... More >> Acute Lymphoblastic Leukemia Chronic Myelogenous Leukemia Myelodysplastic Syndrome Less << Not Applicable Terminated(poor enrollment) - United States, Georgia ... More >> Children's Healthcare of Atlanta Atlanta, Georgia, United States, 30322 Emory University Atlanta, Georgia, United States, 30322 Less <<
NCT01744236 Type 2 Diabetes Phase 4 Completed - Netherlands ... More >> VU University Medical Center Amsterdam, Netherlands, 1081HV Less <<
NCT02890784 Myeloid Leukemia, Chronic Phase 3 Recruiting December 2021 -
NCT02856178 Pulmonary Aspergillosis - Inva... More >>sive Acute Myeloid Leukemia Less << Phase 1 Phase 2 Withdrawn(study no longer requ... More >>ired) Less << - -
NCT01628055 Ischemic Stroke Phase 1 Withdrawn(difficult recruitmen... More >>t and new black box warning for IVIG) Less << - United States, Virginia ... More >> Inova Health Systems; Inova Fairfax Hospital Falls Church, Virginia, United States, 22042 Less <<
NCT03556098 Diabetes Mellitus, Type 1 Not Applicable Recruiting January 1, 2020 Denmark ... More >> Steno Diabetes Center Copenhagen, Clinical Metabolic Physiology Recruiting Hellerup, Denmark, 2900 Contact: Bjørn Hoe, MD    004553634340    bjoern.hoe@regionh.dk    Contact: Filip K Knop, PhD, MD       filip.krag.knop.01@regionh.dk Less <<
NCT03038126 Safety Issues ... More >> Chronic Kidney Disease Less << Not Applicable Completed - United States, Maryland ... More >> Baltimore VA Medical Center Baltimore, Maryland, United States, 21201 Less <<
NCT00516945 Hepatitis B N... More >>eoplasms Less << Not Applicable Completed - China ... More >> Queen Elizabeth Hospital Hong Kong, China Less <<
NCT02092597 Type 2 Diabetes Mellitus Phase 4 Completed - Czechia ... More >> General University Hospital Prague, Czechia, 128 08 Less <<
NCT02521155 Gingivitis De... More >>ntal Plaque Less << Not Applicable Completed - Canada, Quebec ... More >> Faculty of Dental medicine Montreal, Quebec, Canada, H3C3J7 Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

3.34mL

0.67mL

0.33mL

16.70mL

3.34mL

1.67mL

33.41mL

6.68mL

3.34mL

References

 

Historical Records

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