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Chemical Structure| 433267-55-1 Chemical Structure| 433267-55-1

Structure of 433267-55-1

Chemical Structure| 433267-55-1

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Product Details of [ 433267-55-1 ]

CAS No. :433267-55-1
Formula : C7H8BrNO2
M.W : 218.05
SMILES Code : O=C(C1=CC(Br)=CN1)OCC
MDL No. :MFCD06205071
InChI Key :ZNKYCJKUHXQUJQ-UHFFFAOYSA-N
Pubchem ID :5324607

Safety of [ 433267-55-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 433267-55-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 433267-55-1 ]

[ 433267-55-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 72652-32-5 ]
  • [ 141-52-6 ]
  • [ 433267-55-1 ]
YieldReaction ConditionsOperation in experiment
91.3% In ethanol; at 0 - 30℃;Large scale; Example 2 While maintaining the temperature at 20-30 C, anhydrous ethanol (950.0 kg) was charged into a 3000 L glass-lined reactor followed by Compound 8 (342.7 kg). The mixture was cooled to 0-5 C over about 2 h. Sodium alcoholate solution in ethanol (21%, 36.4 kg) was added dropwise over about 1-1.5 h at 0-5 C. The reaction mixture was then heated to about 25-30 C and tested until the content of Compounds 8/9 was < 1.0%. The reaction mixture was concentrated at a temperature< 50 C until about 1.3-1.4 volume of Compound 8 was left. The concentrated mixture was cooled at 25-30 C. The mixture was quenched into cooled water (3427.0 kg) over about 2 h. After addition, the mixture was stirred at 0-5 C over about 2 h for crystallization. The mixture was filtered and the filter cake was rinsed. The solid was dried at 30-40 C over 40-45 h to afford 234.3 kg of Compound 9 , 99.9% purity and 91.3% yield.
 

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