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Structure of 435278-02-7

Chemical Structure| 435278-02-7

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Product Details of [ 435278-02-7 ]

CAS No. :435278-02-7
Formula : C9H5ClFN
M.W : 181.59
SMILES Code : FC1=CC=CC2=C1C=CN=C2Cl
MDL No. :MFCD16883054
InChI Key :HPKPOKQSRYDGAM-UHFFFAOYSA-N
Pubchem ID :22250163

Safety of [ 435278-02-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 435278-02-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 435278-02-7 ]

[ 435278-02-7 ] Synthesis Path-Downstream   1~12

  • 2
  • potassium cyanide [ No CAS ]
  • [ 435278-02-7 ]
  • [ 1369292-33-0 ]
  • 3
  • [ 435278-02-7 ]
  • [ 1179149-35-9 ]
  • 4
  • [ 435278-02-7 ]
  • [ 1429787-93-8 ]
  • 5
  • [ 435278-02-7 ]
  • [ 1429787-95-0 ]
  • 6
  • [ 435278-02-7 ]
  • [ 1429787-78-9 ]
  • 7
  • [ 435278-02-7 ]
  • [ 1429787-85-8 ]
  • 8
  • [ 435278-02-7 ]
  • 5-fluoro-1,3-dichloroisoquinoline [ No CAS ]
  • 9
  • [ 435278-02-7 ]
  • [ 1429787-90-5 ]
  • 10
  • [ 435278-02-7 ]
  • [ 544-97-8 ]
  • [ 31181-17-6 ]
YieldReaction ConditionsOperation in experiment
320 mg With tetrakis(triphenylphosphine) palladium(0); In tetrahydrofuran; at 75℃; for 3h;Inert atmosphere; The dried tetrahydrofuran (8 mL), compound <strong>[435278-02-7]1-chloro-5-fluoroisoquinoline</strong> (480 mg),Dimethylzinc (1mol/L, 12.2mL) and tetrakis(triphenylphosphine)palladium (305mg) were added to the reaction vessel in sequence,The reaction system was replaced with argon and heated to 75C, and the reaction was stirred for 3 hours.Saturated ammonium chloride solution was added to quench, and extracted with dichloromethane, the combined organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, filtered, and concentrated to remove the solvent,After separation and purification by column chromatography, a yellow solid compound 5-fluoro-1-methylisoquinoline (320mg, yield 75%) was obtained;
  • 11
  • [ 410086-25-8 ]
  • [ 435278-02-7 ]
YieldReaction ConditionsOperation in experiment
With trichlorophosphate; at 80℃; for 2h; Add 5-fluoroisoquinolin-1(2H)-one (450mg) to phosphorus oxychloride (8mL),The reaction system was then stirred at 80C for 2 hours.After the reaction was completed, the solvent was concentrated, the reaction residue was dissolved in dichloromethane and washed with saturated sodium bicarbonate solution, the organic phase was washed with saturated brine, dried over anhydrous sodium sulfate, and filtered,Concentrate to remove the solvent to obtain 1-chloro-5-fluoroisoquinoline as a white solid compound (480mg, yield 96%),The product can be used directly in the next step without purification;
  • 12
  • [ 435278-02-7 ]
  • [ 31181-30-3 ]
 

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