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Chemical Structure| 4492-47-1 Chemical Structure| 4492-47-1

Structure of 4492-47-1

Chemical Structure| 4492-47-1

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Product Details of [ 4492-47-1 ]

CAS No. :4492-47-1
Formula : C6H13NO
M.W : 115.17
SMILES Code : OCC1C(N)CCC1
MDL No. :MFCD17015374

Safety of [ 4492-47-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319
Precautionary Statements:P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 4492-47-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 4492-47-1 ]

[ 4492-47-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 330-93-8 ]
  • [ 4492-47-1 ]
  • ethereal HCl [ No CAS ]
  • (+/-) cis-1-Amino-2-[4-(4-fluorophenoxy)phenoxymethyl]cyclopentane hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
In diethyl ether; acetic acid; dimethyl sulfoxide; EXAMPLE 9 (+-) cis-1-Amino-2-[4-(4-fluorophenoxy)phenoxymethyl]cyclopentane hydrochloride A solution of (+-) cis-1-amino-2-hydroxymethylcyclopentane (0.46 g, 4.0 mol) in dry dimethyl sulfoxide (12 ml), was treated with sodium hydride (0.144 g of an 80% dispersion in oil; 4.8 mmol). After stirring for 3 h at room temperature under argon a solution of <strong>[330-93-8]bis-(4-fluorophenyl)-ether</strong> (1.65g, 8.0 mmol) in dimethyl sulfoxide (2 ml) was added. The mixture was heated to 60 C. and held at this temperature for 19 h. The reaction was quenched at ice temperature with glacial acetic acid (0.27 ml, 4.8 mmol) and then worked up as described in Example 5. Purification by chromatography on silica gel eluding with 0-5% ethanol in diethyl ether afforded an oil. The product was extracted into diethyl ether-hexane, and insoluble impurities were discarded. Treatment with ethereal HCl produced the hydrochloride salt which was crystallized to give the title compound as a white solid (0.56 g) m.p. 170-171 C. (from methanol/diethyl ether). 1 H Nmr (DMSO-d6) delta: 1.50-2.10 (6H, m), 2.47 (1H, m), 3.63 (1H, m), 3.97 (1H, m), 4.12 (1H, m), 6.96 (6H, m), 7.18 (2H, m), 8.18 (3H, br s)
 

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