[ CAS No. 4673-31-8 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 4673-31-8
Chemical Structure| 4673-31-8
Structure of 4673-31-8

Quality Control of [ 4673-31-8 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 4673-31-8 ]

SDS

Product Details of [ 4673-31-8 ]

CAS No. :4673-31-8MDL No. :MFCD00152166
Formula :C8H11NBoiling Point :186.7°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :121.18Pubchem ID :-
Synonyms :

Computed Properties of [ 4673-31-8 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 4673-31-8 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P280-P301+P312-P302+P352-P305+P351+P338UN#:N/A
Hazard Statements:H302-H315-H320-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 4673-31-8 ]

  • Upstream synthesis route of [ 4673-31-8 ]

[ 4673-31-8 ] Synthesis Path-Upstream   1~9

  • 1
  • [ 75-03-6 ]
  • [ 4673-31-8 ]
YieldReaction ConditionsOperation in experiment
10%
Stage #1: With N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine In tetrahydrofuran; hexanes at 0℃; for 1.25 h;
Stage #2: at 20℃; for 1.00 h;
i) 3-propyl pyridine At 0°C, to a mixture of diisopropylamine (3.53 ml_, 24.7 mmol) in THF (35 ml_), BuLi (1.6 M in hexanes, 15.4 ml_, 25 mmol) was added drop-wise. After 30 min, HMPA (15.7 g, 24.7 mmol) was aded and the mixture was kept at 00C for 15 min. Then a solution of 3-methyl pyridine (2.3 g, 24.7 mmol) in THF (10 ml.) was added drop-wise. After 30 min, EtI (3.45 g, 24.7 mmol) in THF (10 mL) was added drop-wise and the mixture was then stirred at RT for 1 hour. The mixture was poured into 10percent HCI. The aqueous phase was extracted with Et2O. The organic phase was washed with water, dried over sodium sulfate and concentrated in vacuo to afford a yellow oil (300 mg, 10percent) which will be used without further purification.
Reference: [1] Patent: WO2007/71358, 2007, A1. Location in patent: Page/Page column 32-33
  • 2
  • [ 7300-28-9 ]
  • [ 4673-31-8 ]
Reference: [1] Green Chemistry, 2015, vol. 17, # 3, p. 1408 - 1413
  • 3
  • [ 110-89-4 ]
  • [ 71-23-8 ]
  • [ 4673-31-8 ]
Reference: [1] Russian Journal of Organic Chemistry, 1995, vol. 31, # 2, p. 258 - 259[2] Zhurnal Organicheskoi Khimii, 1995, vol. 31, # 2, p. 289 - 290
  • 4
  • [ 108-99-6 ]
  • [ 4673-31-8 ]
Reference: [1] Journal of the American Chemical Society, 1959, vol. 81, p. 2568,2569
[2] Journal of the American Chemical Society, 1957, vol. 79, p. 1667
[3] Helvetica Chimica Acta, 1956, vol. 39, p. 505,510
[4] Journal of Organic Chemistry, 1957, vol. 22, p. 168
[5] Chem. Weekb., 1956, vol. 52, p. 357
  • 5
  • [ 1570-48-5 ]
  • [ 4673-31-8 ]
Reference: [1] Journal of pharmaceutical sciences, 1980, vol. 69, # 7, p. 850 - 851
[2] Organic and Biomolecular Chemistry, 2006, vol. 4, # 14, p. 2710 - 2715
  • 6
  • [ 626-55-1 ]
  • [ 106-94-5 ]
  • [ 4673-31-8 ]
Reference: [1] Organic Letters, 2017, vol. 19, # 23, p. 6436 - 6439
  • 7
  • [ 5470-02-0 ]
  • [ 4673-31-8 ]
Reference: [1] Russian Journal of Organic Chemistry, 1994, vol. 30, # 9.2, p. 1512[2] Zhurnal Organicheskoi Khimii, 1994, vol. 30, # 9, p. 1438
  • 8
  • [ 626-55-1 ]
  • [ 1239384-16-7 ]
  • [ 6304-18-3 ]
  • [ 4673-31-8 ]
  • [ 1239384-09-8 ]
Reference: [1] Angewandte Chemie - International Edition, 2010, vol. 49, # 26, p. 4447 - 4450
  • 9
  • [ 22083-74-5 ]
  • [ 4673-31-8 ]
Reference: [1] Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences, 1881, vol. 92, p. 1082[2] Jahresbericht ueber die Fortschritte der Chemie und Verwandter Theile Anderer Wissenschaften, 1881, p. 928
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