Name: 4773-96-0|1,3,6,7-Tetrahydroxy-2-((2S,3R,4R,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)-9H-xanthen-9-one|98%
Brand: Ambeed
SKU: A397158
Price: 5.0 USD
Availability: InStock
Rating: 96 (35 reviews)

1
[ 92631-83-9 ]
[ 24699-16-9 ]
[ 4773-96-0 ]

Reference： [1]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686
[2]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686

2
[ 92631-82-8 ]
[ 149-91-7 ]
[ 4773-96-0 ]

Reference： [1]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686

3
6′-O-acetyl mangiferin [ No CAS ]
[ 4773-96-0 ]

Reference： [1]Phytochemistry,1980,vol. 19,p. 415

4
[ 4773-96-0 ]
[ 3542-72-1 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; recorcinol; In water; for 6.0h;Reflux;	To a solution of <strong>[4773-96-0]mangiferin</strong> (300 mg, 0.710 mmol) in 3 N HCl(10 mL) was added resorcinol (117 mg, 1.06 mmol) at ambient temperature. The reactionmixture was refluxed for 6 h and then cooled to ambient temperature. The reaction mixturewas slowly quenched with saturated NaHCO3 solution and stirred for 30 min. Thebrown precipitate was collected by filtration, washed with H2O, and then concentrated invacuo. The residue was purified by flash column chromatography on silica gel (gradient50% EtOAc in n-hexane to only EtOAc) to afford 131 mg (71%) of the crude norathyriol.After recrystallization with ethanol, pure norathyriol was obtained as a yellowish solid,mp. >320C (decomp.). The NMR spectral data were identical with those reported8: 1HNMR (800 MHz, DMSO-d6) d 13.16 (s, 1 H), 10.76 (bs, 1H), 7.37 (s, 1H), 6.85 (s, 1H),6.31 (d, 1H, J D 2.1 Hz), 6.14 (d, 1H, J D 2.1 Hz); 13C NMR (800 MHz, DMSO-d6) d178.9, 164.7, 162.6, 157.3, 154.0, 150.9, 143.7, 111.8, 108.0, 102.6, 101.6, 97.7, 93.6;LR-MS (FABC) m/z 261 (MCHC); HR-MS (FABC) calcd for C13H9O6 (MCHC)261.0394; found: 261.0399.
	With hydrogenchloride; recorcinol; In water; at 150℃; for 6.0h;Green chemistry;	Mangiferin in 3N HCl (10 mL, sigma-aldrich) solution(300 mg, 0.71 mmol, Xian Lyphar Biotech) with resorcinol(1.06 mmol, 1.5 equiv, TCI) was added and heated to reflux (150 C.) for 6 hours.After cooling the refluxed solution to room temperature (25 C.), saturated sodium bicarbonate (NaHCO 3) solution was slowly added to neutralize the mixed solution.The mixed solution was stirred for 30 minutes, then filtered and the solids washed with water.The dried solid was vacuum dried to give brown crude norathiol(crude norathyriol, yield: 71%, 131 mg) was obtained.Crude noratiriol was added to ethyl acetate (10 mL), heated, stirred for 30 minutes, cooled to room temperature (25 C.), and filtered. The solid was washed several times with ethyl acetate, and then the filtrate was concentrated to give noraritol.

Reference： [1]Chemistry of Natural Compounds,1980,vol. 16,p. 145 - 149
Khimiya Prirodnykh Soedinenii,1980,p. 190 - 195
[2]Organic Preparations and Procedures International,2018,vol. 50,p. 91 - 94
[3]Patent: KR2019/55918,2019,A .Location in patent: Paragraph 0032-0087

6
[ 108-24-7 ]
[ 4773-96-0 ]
[ 4706-56-3 ]

Yield	Reaction Conditions	Operation in experiment
78%	With iodine; at 130℃; for 0.25h;Microwave irradiation;	Mangiferin (3, 0.2 g, 0.5 mmol) and iodine (0.009 g, 0.07 mmol) were mixed in acetic anhydride (7 mL) and the reaction was kept under MW irradiation (400 W), at 130 C, for 15 min. After cooling, a saturated solution of sodium thiosulfate was added to convert iodine (dark yellow) into iodide (yellow). The crude product was extracted with CH2Cl2 and the organic layer was extracted with a saturated solution of NaHCO3 twice, dried with anhydrous Na2SO4, and filtered. The solvent was evaporated under reduced pressure and the oil obtained was dissolved in ethyl acetate. A yellow solid was obtained with petroleum ether 60-80 C corresponding to1,3,6,7-tetra-O-acetyl-2-C-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyl)-9H-xanthen-9-one (7) (0.294 g, 0.39 mmol, 78 % yield); mp 143-147 C (petroleum ether 60-80 C).

Reference： [1]Molecules,2018,vol. 23
[2]Biological and Pharmaceutical Bulletin,2005,vol. 28,p. 596 - 600

7
[ 102-92-1 ]
[ 4773-96-0 ]
2-β-D-glucopyranosyl-7-cinnamoyloxy-1,3,6-trihydroxy-9H-xanthen-9-one [ No CAS ]

Reference： [1]Biological and Pharmaceutical Bulletin,2005,vol. 28,p. 596 - 600

8
[ 77-78-1 ]
[ 4773-96-0 ]
2-β-D-tetrahydroxyglucopyranosyl-3,6,7-trimethoxy-1-hydroxy-9H-xanthen-9-one [ No CAS ]

Reference： [1]Biological and Pharmaceutical Bulletin,2005,vol. 28,p. 596 - 600

9
[ 102-92-1 ]
[ 4773-96-0 ]
2-β-D-glucopyranosyl-1,3,6,7-tetrahydroxy-9H-xanthen-9-one [ No CAS ]

Reference： [1]Magnetic Resonance in Chemistry,2006,vol. 44,p. 838 - 844

10
[ 102-92-1 ]
[ 4773-96-0 ]
2-β-D-tetracinnamoylglucopyranosyl-7-cynnamoyloxy-1,3,6-trihydroxy-9H-xanthen-9-one [ No CAS ]

Reference： [1]Magnetic Resonance in Chemistry,2006,vol. 44,p. 838 - 844

11
[ 4773-96-0 ]
[ 2054-37-7 ]

Reference： [1]Chemistry of Natural Compounds,1980,vol. 16,p. 145 - 149
Khimiya Prirodnykh Soedinenii,1980,p. 190 - 195

12
[ 92665-82-2 ]
[ 4773-96-0 ]

Reference： [1]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686

13
[ 92631-85-1 ]
[ 4773-96-0 ]

Reference： [1]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686

14
[ 92631-84-0 ]
[ 4773-96-0 ]

Reference： [1]Chemical and pharmaceutical bulletin,1984,vol. 32,p. 2676 - 2686

Yield	Reaction Conditions	Operation in experiment
		Mangiferin is filtered-off, disintegrated and recrystallized from a mixture dioxane-water (1:1). There is obtained 0.1 kg of mangiferin. The yield of mangiferin is equal to 1% by weight of the starting stock.
		Mangiferin is filtered-off, dried, disintegrated and recrystallized from a mixture dioxane-water (1:2). There are obtained 0.1 kg of mangiferin. The yield of mangiferin is 1.0% by weight of the starting feedstock.
		Mangiferin is filtered-off, dried, disintegrated and recrystallized from a mixture dioxane-water (1:1) to give 0.1 kg of mangiferin. The yeld of mangiferin is equal to 1.0% by weight of the starting feedstock.

16
[ 4773-96-0 ]
[ 929635-04-1 ]

Yield	Reaction Conditions	Operation in experiment
81.7%	With sodium carbonate; In ethanol; water;Product distribution / selectivity;	Example 2 : Preparation of sodium <strong>[4773-96-0]mangiferin</strong>; Mangiferin 42.2(0. lmol) is suspend in the mixture of water 100ml and ethanol 900ml in reactor ,mixing round adequately. Sodium carbonate 5.30g(0.05mol) is dissolved in water , the concentration is 0.1 %( w/v) . The solution of sodium carbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity actone is added into the reaction solution, mixing round adequately . A lot of deposition is come into being , the reaction solution is filtrated to get the depositon, the solid substance is heated up not excess 60 C to dry .the yellow substance is sodium <strong>[4773-96-0]mangiferin</strong>. Its weight is 34.5g, the productivity is 81.7%. The purity of sodium <strong>[4773-96-0]mangiferin</strong> is 95% detected by HPLC.Compound identify:13CNMR(DMSO-d6) (deltappm): 161.7(C-I), 106.9(C-2), 146.6(C-3), 93.2(C-4), 155.9 ( C-4a), 100.6(C-4b), 102.7(C-5), 153.7(C-6), 177.5(C - 9), 73.5(C-I '), 70.5(C-2'), 79.0(C-3'), 70.3(C-4') , 81.2(C-5'), 61.1(C-6'). <n="9"/>13CNMR data of <strong>[4773-96-0]mangiferin</strong> in reference document [ ^ic^g , fj§^>beta . M Ht^P M^Mepsilon^MfrM^f°&fe. MpsipsiM, 1997; 32 (6): 473-475] :13CNMR(DMSO-d6) (deltappm): 161.6(C-I), 107.3(C-2), 163.6(C-3), 93.9(C-4), 156.1 ( C-4a), 101.2(C-4b), 102.5(C-5), 153.6(C-6), 143.7(C-7), 108.1(C-8), 118.7(C-8a), 150.7(C-8b), 179.0(C - 9), 73.0(C-I '), 70.5(C-2'), 78.8(C-3'), 70.3(C-4') , 81.3(C-5'), 61.4(C-6').According to the reference literature of <strong>[4773-96-0]mangiferin</strong> structure identify [ ^TJC ^H , w&m. MpsipsiU, mi-, 32 (6): 473-475 ] , the sodium <strong>[4773-96-0]mangiferin</strong> 13CNMR data reveal: The chemical shift of C-3 displace to high-frequency magnetic field markedly, The chemical shift of C-2, C-4, C-4a, C-4b and C-9 displace to high-frequency magnetic field too.According the sodium <strong>[4773-96-0]mangiferin</strong> 13CNMR data and the process of sodium <strong>[4773-96-0]mangiferin</strong> preparation, we deduce the sodium is linked to the position C-3 hydroxy of <strong>[4773-96-0]mangiferin</strong> .

Reference： [1]Patent: WO2008/61480,2008,A1 .Location in patent: Page/Page column 7-8

17
[ 4773-96-0 ]
[ 1158716-92-7 ]

Yield	Reaction Conditions	Operation in experiment
78.1%	With sodium hydrogencarbonate; In ethanol; water;Product distribution / selectivity;	Example 3 : Preparation of sodium <strong>[4773-96-0]mangiferin</strong>; Mangiferin 42.2(0. lmol) is suspend in the mixture of water 900ml and ethanol 100ml in reactor, mixing round adequately. Sodium bicarbonate 9.24g(0.11mol) is dissolved in water ,the concentration is 5%( w/v) . The solution of sodium bicarbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity ethanol-ethyl acetate(l :1.5 v/v) is added into the reaction solution, mixing round adequately . A lot of deposition is come into being, the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess 60 C to dry . The yellow substance is sodium <strong>[4773-96-0]mangiferin</strong>. Its weight is 32.96g, the productivity is 78.1%. The purity of sodium <strong>[4773-96-0]mangiferin</strong> is 92% detected by HPLC.

Reference： [1]Patent: WO2008/61480,2008,A1 .Location in patent: Page/Page column 8

18
[ 4773-96-0 ]
mangiferin calcium [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
90.4 - 91.2%	With calcium hydroxide; In dimethyl sulfoxide; glycerol;Product distribution / selectivity;	Example 9: Preparation of <strong>[4773-96-0]mangiferin</strong> calcium <strong>[4773-96-0]mangiferin</strong> 4.2g(0.01mol) is dissolved into 50ml DMSO, calcium hydroxide 0.37g(0.005mol) is dissolved in 80g glycerol, calcium hydroxide solution is added slowly into <strong>[4773-96-0]mangiferin</strong> solution while mixing round, mixing round until it reacte completely. Appropriate quantity ethanol is added into the reaction solution, mixing <n="12"/>round adequately. A lot of deposition is come into being in solution. The reaction solution is filtrated to get the depositon . This deposition is heated up no excess 60 C to dry. The yellow green solid substance is <strong>[4773-96-0]mangiferin</strong> calcium. Its weight is 3.8g, the productivity is 90.4%. Example 10: Preparation of <strong>[4773-96-0]mangiferin</strong> calcium; <strong>[4773-96-0]mangiferin</strong> 4.2g(0.01mol)is dissolved into 80ml DMSO, calcium hydroxide 1.48g(0.02mol) is dissolved in 20Og glycerol, calcium hydroxide solution is added slowly into <strong>[4773-96-0]mangiferin</strong> solution while mixing round , mixing round until it reacte completely. Appropriate quantity ethanol is added into the reaction solution, mixing round adequately . A lot of deposition is come into being in solution. The reaction solution is filtrated to get the depositon. This deposition is heated up no excess 60 C to dry. The yellow green solid substance is <strong>[4773-96-0]mangiferin</strong> calcium. Its weight is 3.83g, the productivity is 91.2%.
82.1%	With potassium hydrogencarbonate; In ethanol; water;Product distribution / selectivity;	Example 5 : Preparation of potassium <strong>[4773-96-0]mangiferin</strong>; Mangiferin 42.2(0. lmol) is suspended in the mixture of water 400ml and ethanol 1600ml in reactor ,mixing round adequately. Potassium bicarbonate 10.0g(0. lmol) is dissolved in water , the concentration is 0.1%( w/v) . The solution of potassium bicarbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity ethanol-dichloroform (7:1 v/v) is added into the reaction solution, mixing round adequately . A lot of deposition is come into being , the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess 60 C to dry .The yellow substance is potassium <strong>[4773-96-0]mangiferin</strong> . Its weight is 34.65g, the productivity is 82.1%. The purity of potassium <strong>[4773-96-0]mangiferin</strong> is 94% detected by HPLC.

Reference： [1]Patent: WO2008/61480,2008,A1 .Location in patent: Page/Page column 10-11
[2]Patent: WO2008/61480,2008,A1 .Location in patent: Page/Page column 9

19
[ 584-08-7 ]
[ 4773-96-0 ]
[ 1158716-92-7 ]
[ 1158716-92-7 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; water;Product distribution / selectivity;	Example 4: Preparation of <strong>[4773-96-0]mangiferin</strong> monopotassiumMangiferin 42.2(0. lmol) is suspended in the mixture of water 200ml and methanol 1800ml in reactor, mixing round adequately. Potassium carbonate 6.9g(0.05mol) is dissolved in water ,the concentration is 0.2%( w/v ) . The solution of potassium carbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear, then the reaction solution is filtrated, appropriate quantity ethanol- chloroform (4:1 v/v) is added into the reaction solution, mixing round adequately . A lot of deposition is come into being, the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess <n="12"/>60 C to dry. The yellow substance is <strong>[4773-96-0]mangiferin</strong> monopotassium. Its weight is 3 Ig, the productivity is 73.4%. The purity of <strong>[4773-96-0]mangiferin</strong> monopotassium is 98.6% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 10-11

20
[ 144-55-8 ]
[ 4773-96-0 ]
[ 929635-04-1 ]
[ 929635-04-1 ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; water;Product distribution / selectivity;	Example 2: Preparation of <strong>[4773-96-0]mangiferin</strong> monosodiumMangiferin 42.2(0. lmol) is suspended in the mixture of water 1800ml and ethanol 600ml in reactor, mixing round adequately. Sodium bicarbonate 8.4g(0.1mol) is dissolved in water ,the concentration is 0.5%( w/v) . The solution of sodium bicarbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity ethanol-ethyl acetate(l :1.5 v/v) is added into the reaction solution, mixing round adequately . A lot of deposition is come into being, the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess 60C to dry . The yellow substance is <strong>[4773-96-0]mangiferin</strong> monosodium. Its weight is 31.2g, the productivity is 74%. The purity of <strong>[4773-96-0]mangiferin</strong> monosodium is 98.6% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 10

21
[ 497-19-8 ]
[ 4773-96-0 ]
[ 929635-04-1 ]
[ 929635-04-1 ]

Yield	Reaction Conditions	Operation in experiment
	In ethanol; water;Product distribution / selectivity;	Example 3: Preparation of <strong>[4773-96-0]mangiferin</strong> monosodiumMangiferin 42.2(0. lmol) is suspend in the mixture of water 1800ml and ethanol 900ml in reactor ,mixing round adequately. Sodium carbonate 5.30g(0.05mol) is dissolved in water , the concentration is 0.5%( w/v ) . The solution of sodium carbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity actone is added into the reaction solution, mixing round adequately . A lot of deposition is come into being , the reaction solution is filtrated to get the depositon, the solid substance is heated up not excess 60C to dry .the yellow substance is <strong>[4773-96-0]mangiferin</strong> monosodium. Its weight is 31.4g, the productivity is 74.5%. The purity of <strong>[4773-96-0]mangiferin</strong> monosodium is 98.5% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 10

22
calcium hydroxide [ No CAS ]
[ 4773-96-0 ]
mangiferin calcium [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In dimethyl sulfoxide; glycerol;Product distribution / selectivity;	Example 12: Preparation of <strong>[4773-96-0]mangiferin</strong> calcium <strong>[4773-96-0]mangiferin</strong> 4.2g(0.01mol) is dissolved into 50ml DMSO, calcium hydroxide 0.37g(0.005mol) is dissolved in 8Og glycerol, calcium hydroxide solution is added slowly into <strong>[4773-96-0]mangiferin</strong> solution while mixing round, mixing round until it reacte completely. Appropriate quantity ethanol is added into the reaction solution, mixing round adequately. A lot of deposition is come into being in solution. The reaction solution is filtrated to get the depositon . This deposition is heated up no excess 600C to dry. The yellow green solid substance is <strong>[4773-96-0]mangiferin</strong> calcium. Its weight is 3.8g, the productivity is 90.4%. The purity of <strong>[4773-96-0]mangiferin</strong> monopotassium is 71.2% detected by HPLC. Example 13: Preparation of <strong>[4773-96-0]mangiferin</strong> calcium <strong>[4773-96-0]mangiferin</strong> 4.2g(0.01mol)is dissolved into 80ml DMSO, calcium hydroxide 1.48g(0.02mol) is dissolved in 20Og glycerol, calcium hydroxide solution is added slowly into <strong>[4773-96-0]mangiferin</strong> solution while mixing round , mixing round until it reacte completely. Appropriate quantity ethanol is added into the reaction solution, mixing round adequately . A lot of deposition is come into being in solution. The reaction solution is filtrated to get the depositon. This deposition is heated up no excess 60 C to dry. The yellow green solid substance is <strong>[4773-96-0]mangiferin</strong> calcium. Its weight is 3.83g, the productivity is 91.2%. The purity of <strong>[4773-96-0]mangiferin</strong> monopotassium is 63.8% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 13

23
[ 298-14-6 ]
[ 4773-96-0 ]
[ 1158716-92-7 ]
[ 1158716-92-7 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; water;Product distribution / selectivity;	Example 5: Preparation of <strong>[4773-96-0]mangiferin</strong> monopotassiumMangiferin 42.2(0. lmol) is suspended in the mixture of water 1000ml and methanol 1000ml in reactor ,mixing round adequately. Potassium bicarbonate 10.0g(0. lmol) is dissolved in water , the concentration is 0.1 %( w/v) . The solution of potassium bicarbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity ethanol-dichloroform (7: 1 v/v) is added into the reaction solution, mixing round adequately . A lot of deposition is come into being , the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess 60 C to dry .The yellow substance is <strong>[4773-96-0]mangiferin</strong> monopotassium . Its weight is 31.7g, the productivity is 75%. The purity of <strong>[4773-96-0]mangiferin</strong> monopotassium is 98.7% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 11

24
[ 4773-96-0 ]
[ 1158716-92-7 ]
[ 1158716-92-7 ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; water;Product distribution / selectivity;	Example 6: Preparation of <strong>[4773-96-0]mangiferin</strong> monosodiumMangiferin 42.2(0. lmol) is suspended in the mixture of water 1800ml and methanol 900ml in reactor ,mixing round adequately. Sodium carbonate 5.30g(0.05mol) is dissolved in water , the concentration is 5%( w/v) . The solution of sodium carbonate is added slowly into the <strong>[4773-96-0]mangiferin</strong> suspended solution while mixing round until the solution is clear , then the reaction solution is filtrated, appropriate quantity ethyl acetate is added into the reaction solution, mixing round adequately . A lot of deposition is come into being , the reaction solution is filtrated to get the depositon, the solid substance is heated up no excess 60C to dry .The yellow substance is <strong>[4773-96-0]mangiferin</strong> monopotassium . Its weight is 32.3g, the productivity is76.5%. The purity of <strong>[4773-96-0]mangiferin</strong> monopotassium is 98.5% detected by HPLC.

Reference： [1]Patent: WO2009/65287,2009,A1 .Location in patent: Page/Page column 11

25
[ 108-05-4 ]
[ 4773-96-0 ]
6′-O-acetyl mangiferin [ No CAS ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

26
[ 123-20-6 ]
[ 4773-96-0 ]
[ 1231632-28-2 ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

27
[ 3050-69-9 ]
[ 4773-96-0 ]
[ 1231632-30-6 ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

28
[ 818-44-0 ]
[ 4773-96-0 ]
[ 1231632-32-8 ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

29
[ 4704-31-8 ]
[ 4773-96-0 ]
[ 1231632-33-9 ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

30
[ 2146-71-6 ]
[ 4773-96-0 ]
[ 1231632-36-2 ]

Reference： [1]Journal of Asian Natural Products Research,2010,vol. 12,p. 56 - 63

31
[ 1239694-50-8 ]
[ 4773-96-0 ]

Reference： [1]Journal of Organic Chemistry,2010,vol. 75,p. 5725 - 5728

32
C₁₉H₁₈O₁₁*C₄₂H₇₀O₃₅ [ No CAS ]
[ 4773-96-0 ]
[ 7585-39-9 ]

Reference： [1]Electrochimica Acta,2010,vol. 56,p. 797 - 803

33
[ 4773-96-0 ]
[ 7585-39-9 ]
C₁₉H₁₈O₁₁*C₄₂H₇₀O₃₅ [ No CAS ]

Reference： [1]Electrochimica Acta,2010,vol. 56,p. 797 - 803

34
[ 4773-96-0 ]
mangiferin 2',3,3',4',6,6',7-O-heptasulfate [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 5373 - 5384

35
[ 4773-96-0 ]
[ 1314004-00-6 ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 5373 - 5384

36
[ 4773-96-0 ]
C₁₉H₁₄O₂₃S₄^(4-)*4Na⁽¹⁺⁾ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 5373 - 5384

37
[ 4773-96-0 ]
C₁₉H₁₁O₃₂S₇^(7-)*7Na⁽¹⁺⁾ [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2011,vol. 54,p. 5373 - 5384

38
[ 4773-96-0 ]
[ 57-50-1 ]
β-D-fructofuranosyl(2→6)mangiferin [ No CAS ]
β-D-difructofuranosyl(2→6)mangiferin [ No CAS ]
β-D-trifructofuranosyl(2→6)mangiferin [ No CAS ]

Reference： [1]RSC Advances,2013,vol. 3,p. 19027 - 19032

39
[ 4773-96-0 ]
[ 57-50-1 ]
β-D-fructofuranosyl(2→6)mangiferin [ No CAS ]
C₃₁H₃₈O₂₁ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
158.5 g; 39.1 g	With Arthrobacter nicotianae XM6 fructosylating enzyme liquor; In aq. phosphate buffer; at 30℃; for 360.0h;pH 6.86;Enzymatic reaction;	Add 600 mL of supernatant enzyme liquor into a 5 L fermenting tank with total volume of 3000 mL of 1/15 mol/L phosphate buffer (pH6.86) containing 62.7 g/L of <strong>[4773-96-0]mangiferin</strong> (purchased from Nanjing Zelang Medical Science and Technology Co., Ltd.), 200 g/L of cane sugar, for <strong>[4773-96-0]mangiferin</strong> glycosylating reaction at 30 C. and 300 rpm, after 360 hours, heat it for 2 hours at 45 C. to terminate the transformation reaction. The transformed liquid is determined with HPLC as: containing monofructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> of 63.0 g/L, and bifructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> of 15.7 g/L, so the fructosylated <strong>[4773-96-0]mangiferin</strong> transformation rate is as high as 87%. As shown in FIG. 1, it is <strong>[4773-96-0]mangiferin</strong> with a retaining time of 14.781 min, monofructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> with a retaining time of 8.951 min and bifructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> with a retaining time of 5.541 min.The said transformed liquid containing fructosylated <strong>[4773-96-0]mangiferin</strong> is absorbed with AB-8 macroporous resin (with a chromatographic column of 40×600 mm, at a flow rate of 10 mL/min), then the remaining glycosyl donor is washed off with pH44.5 distilled water (the pH regulated with glacial acetic acid) at a volume 10 times the column bed volume, followed by gradient elution with 5%-30% methanol solution, to obtain fructosylated <strong>[4773-96-0]mangiferin</strong> (with purity >97%), and finally the pigment and <strong>[4773-96-0]mangiferin</strong> are washed off with 100% methanol.The fructosylated <strong>[4773-96-0]mangiferin</strong> with purity >97% is dried by rotary evaporation at 45 C. or freezing, to obtain monofructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> powder or crystal of 158.5 g, and bifructosyl-beta-(2,6)-<strong>[4773-96-0]mangiferin</strong> powder or crystal of 39.1 g.

Reference： [1]Patent: US2014/221643,2014,A1 .Location in patent: Paragraph 0055-0057; 0070; 0071; 0073-0075

40
[ 92631-83-9 ]
[ 4773-96-0 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 12678 - 12682
Angew. Chem.,2015,vol. 127,p. 12869 - 12873,5

41
[ 519-34-6 ]
[ 2492-87-7 ]
[ 4773-96-0 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 12678 - 12682
Angew. Chem.,2015,vol. 127,p. 12869 - 12873,5

42
[ 133-89-1 ]
[ 519-34-6 ]
[ 4773-96-0 ]

Reference： [1]Angewandte Chemie - International Edition,2015,vol. 54,p. 12678 - 12682
Angew. Chem.,2015,vol. 127,p. 12869 - 12873,5

43
[ 4773-96-0 ]
C₄₀H₃₆BO₂₂ [ No CAS ]

Reference： [1]Patent: CN103193767,2016,B

44
[ 4773-96-0 ]
[ 21794-66-1 ]

Reference： [1]Patent: CN103193767,2016,B
[2]Patent: CN103193767,2016,B

45
[ 11113-50-1 ]
[ 4773-96-0 ]
C₃₈H₃₂BO₂₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In methanol; at 20℃; for 1.0h;	Referred to as formula II takes 4.22g (0.01mol) and 1.24g (0.02mol) of boric acid were dissolved in 200ml of anhydrous methanol was stirred at room temperature for 1 hour. To the reaction mixture was added 1.76g (0.02mol) of potassium carbonate, 3.60g (0.04mol) of dimethyl carbonate, and the mixture was heated to 60 , after stirring for 10 hours the reaction was allowed to cool, the reaction solution was concentrated to a yellow solid was precipitated, filtered , washed with deionized water and dried to obtain 4.09g yellow powder, is a compound of formula IV, yield was 91.9%.

Reference： [1]Patent: CN103193767,2016,B .Location in patent: Paragraph 0045

46
[ 67-56-1 ]
[ 4773-96-0 ]
mangiferdiol [ No CAS ]
mangiferinol [ No CAS ]
isomangiferinol [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40.7 mg; 5.9 mg; 14.1 mg	Irradiation;	A sample solution of <strong>[4773-96-0]mangiferin</strong> (500 mg) in MeOH(300 mL) in chapped vials was irradiated with 50 kGy(absorbed dose). The dried irradiated sample were successivelymonitored by reversed-phase HPLC analysisand showed significant enhanced inhibitory activitywith an IC50 value of 107.1 ± 2.1 mug/mL against NOproduction in LPS-stimulated RAW 264.7 macrophagecells using a previously reported method.9) A part ofirradiated sample (300 mg) was directly subjected tocolumn chromatography over a YMC GEL ODS AQ120-50S column (1.5 cm i.d. × 40 cm) with H2O containingincreasing amounts of MeOH in a stepwisegradient to yield pure new compounds 2 (40.7 mg, tR7.2 min), 3 (5.9 mg, tR 9.5 min), and 4 (14.1 mg,tR 10.3 min) (Fig. 1). Reversed-phase HPLC analysiswas carried out on a YMC-Pack ODS A-302 column(4.6 mm i.d. × 150 mm; YMC Co., Ltd.) and the solventsystem consisted of a linear gradient that startedwith MeCN in 0.1% HCOOH/H2O (detection: UV280 nm; flow rate: 1.0 ml/min; at 40 C), increased to50% MeCN over 15 min, and then increased to 100%MeCN over 20 min.

Reference： [1]Bioscience, Biotechnology and Biochemistry,2016,vol. 80,p. 2022 - 2024

47
copper(II) nitrate trihydrate [ No CAS ]
[ 7732-18-5 ]
[ 4773-96-0 ]
C₁₉H₂₀CuO₁₃*5H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
46%	With triethylamine; In ethanol; at 65℃; for 5.0h;pH 7.5;	H-MF (0.2 mmol,0.085 g) was dissolved in ethanol (10 mL) and water (6 mL) and the solution was adjusted to pH 7.5 by addition of triethylamine,yielding a clear yellow solution. Cu(NO3)2·3H2O (0.2 mmol,0.049 g), dissolved in 6 mL ethanol, was added dropwise to thissolution. The mixed solution was stirred at 65 C for 5 hours, and 1precipitated as a green powder. The product was filtered and washedwith anhydrous ethanol before being dried in vacuo overnight.Yield: 46%; m.p.: >300 C decomposed; main IR peaks (KBr,cm-1): 3419 (s, vO-H), 3078 (m, vAr-H), 1611 (vs, vC=O), 1588 (vs, vC=C),1085 (m, vC-O-C), 618 (w, rW(H2O)), 520 (w, vCu-O); Anal. calcd forC19H30CuO18: C, 37.41; H, 4.96; found: C, 37.36; H, 4.90%; ESI-MS:m/z (-MS) 500.18 [Cu(MF)(OH)-H]-, 421.11 [MF]-; Solubility:0.8 g/100 g H2O.

Reference： [1]Journal of Chemical Research,2016,vol. 40,p. 659 - 663

48
zinc(II) nitrate hexahydrate [ No CAS ]
[ 7732-18-5 ]
[ 4773-96-0 ]
C₁₉H₂₀O₁₃Zn*4H₂O [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
40%	With triethylamine; In methanol; ethanol; at 65℃; for 6.0h;pH 7.5;	H-MF (0.2 mmol,0.085 g) was dissolved in methanol (10 mL) and water (4 mL) andthe solution was adjusted to pH 7.5 by addition of triethylamine,yielding a clear yellow solution. Zn(NO3)2·6H2O (0.2 mmol,0.060 g) dissolved in ethanol (6 mL) was added dropwise to thissolution. The mixed solution was stirred at 65 C for 6 hours, anda yellow precipitate formed. The product was filtered and washedwith anhydrous methanol before being dried in vacuo. Yield:40%; m.p.: >300 C decomposed; main IR peaks (KBr, cm-1):3394 (s, vO-H), 3078 (m, vAr-H), 1610 (vs, vC=O), 1565 (vs, vC=C),1081 (m, vC-O-C), 610 (w, rW(H2O)), 515 (w, vZn-O); Anal. calcd forC19H28ZnO17: C, 38.43; H, 4.75; found; C, 38.39; H, 4.67%; ESIMS:m/z (-MS) 519.00 [Zn(MF)(OH)(H2O)-H]-, 421.13 [MF]-;Solubility: 0.25 g/100 g H2O.

Reference： [1]Journal of Chemical Research,2016,vol. 40,p. 659 - 663

49
[ 4291-69-4 ]
[ 4773-96-0 ]