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Chemical Structure| 49612-21-7 Chemical Structure| 49612-21-7

Structure of 49612-21-7

Chemical Structure| 49612-21-7

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Product Details of [ 49612-21-7 ]

CAS No. :49612-21-7
Formula : C10H11N3O
M.W : 189.21
SMILES Code : NNC1=CC=NC2=CC=C(OC)C=C12

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Application In Synthesis of [ 49612-21-7 ]

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  • Downstream synthetic route of [ 49612-21-7 ]

[ 49612-21-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 42881-66-3 ]
  • [ 49612-21-7 ]
YieldReaction ConditionsOperation in experiment
C. (6-Methoxy-quinolin-4-yl)-hydrazine. To a solution of 4-bromo-6-methoxy-quinoline (5.4 g, 28 mmol) in 1-methyl-2-pyrrolidinone (27 mL) was added hydrazine (1.52 mL, 33.6 mmol). The reaction was heated at 150 C. for 12 h. The reaction was then cooled to RT and added dropwise to an ethereal solution (700 mL) at RT. The white precipitate was collected by filtration, washed with Et2O (80 mL), and dried under reduced pressure. The resulting solid was dissolved in CH2Cl2 (100 mL) and washed with 1 N NaOH (100 mL). The aqueous layer was back-extracted with CH2Cl2 (2*100 mL). The combined organic layers were washed with 1 N NaOH (50 mL), brine (30 mL), dried (MgSO4), filtered and concentrated to afford 4.3 g (82% crude) of a brown solid. HPLC: Rt=4.22 min. MS (ESI): exact mass calculated for C10H11N3O, 189.1; m/z found, 190.4 [M+H]+. 1H NMR (500 MHz, CDCl3): 8.26 (d, J=6.5, 1H), 7.75 (d, J=9.2, 1H), 7.52 (d, J=2.5, 1H), 7.46 (dd, J=9.2, 2.6, 1H), 7.19 (d, J=6.5, 1H), 3.95 (s, 3H).
 

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