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Chemical Structure| 49660-93-7 Chemical Structure| 49660-93-7

Structure of 49660-93-7

Chemical Structure| 49660-93-7

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Product Details of [ 49660-93-7 ]

CAS No. :49660-93-7
Formula : C10H11BrO
M.W : 227.10
SMILES Code : CC(C)C(C1=CC=C(Br)C=C1)=O
MDL No. :MFCD09891214
Boiling Point : No data available
InChI Key :PMFLKZHWZXWOEH-UHFFFAOYSA-N
Pubchem ID :15074783

Safety of [ 49660-93-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 49660-93-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 49660-93-7 ]

[ 49660-93-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 49660-93-7 ]
  • [ 2051-99-2 ]
YieldReaction ConditionsOperation in experiment
With hydrazine hydrate; potassium hydroxide; In diethylene glycol; at 80 - 120℃; for 3h; In a 5L four-neck reaction flask, add diethylene glycol (2.25L), potassium hydroxide (585g), 1- (4-bromophenyl) -2-methylpropane-1-one (790g), and heat up To 80 to 90 C; slowly add hydrazine hydrate (533g) at a controlled temperature of 105 to 120 C, which takes about 2 hours. After the addition was completed, the reaction was maintained at 110-120 C for 1 hour, and the system changed from light yellow to reddish brown. The reflux device was changed to atmospheric distillation, and the system slowly warmed up, and excess hydrazine hydrate and water were distilled off, while some products were stripped off. It takes about 3 hours until the internal temperature of the system is greater than 180 C, and the system has reddish brown to pale yellow or lighter color. The atmospheric distillation was changed to reflux, and the reaction was held at 180-200 C for 1 hour. Then drop to room temperature.3.5 L of water was added to the reaction system, stirred for 30 minutes, and extracted three times with methyl tert-butyl ether (2 × 1500 mL + 1000 mL). The organic phases were combined, and the organic phases were washed once with saturated brine (500 mL) and dried over anhydrous sodium sulfate. And concentrated to give a crude product.Distillation: (oil pump about 1mmHg, external temperature 100-125 C), 30cm packed column, collect the distillation head temperature 40-50 C fractions to obtain 1-bromo 4-isobutylbenzene, (central control one), molar yield 52.8%, product purity 89.6%, no other positional isomers were detected. The GC spectrum of the product is shown in Figure 1.
 

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Technical Information

• Alkyl Halide Occurrence • Baeyer-Villiger Oxidation • Barbier Coupling Reaction • Baylis-Hillman Reaction • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Bucherer-Bergs Reaction • Clemmensen Reduction • Corey-Bakshi-Shibata (CBS) Reduction • Corey-Chaykovsky Reaction • Fischer Indole Synthesis • Friedel-Crafts Reaction • General Reactivity • Grignard Reaction • Henry Nitroaldol Reaction • Hiyama Cross-Coupling Reaction • Horner-Wadsworth-Emmons Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Leuckart-Wallach Reaction • McMurry Coupling • Meerwein-Ponndorf-Verley Reduction • Passerini Reaction • Paternò-Büchi Reaction • Petasis Reaction • Peterson Olefination • Pictet-Spengler Tetrahydroisoquinoline Synthesis • Preparation of Aldehydes and Ketones • Preparation of Alkylbenzene • Preparation of Amines • Prins Reaction • Reactions of Aldehydes and Ketones • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Reformatsky Reaction • Robinson Annulation • Schlosser Modification of the Wittig Reaction • Schmidt Reaction • Specialized Acylation Reagents-Ketenes • Stille Coupling • Stobbe Condensation • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling • Tebbe Olefination • Ugi Reaction • Vilsmeier-Haack Reaction • Wittig Reaction • Wolff-Kishner Reduction

Categories

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