[ CAS No. 5034-06-0 ] {[proInfo.proName]}

Name: 5034-06-0|trimethyloxosulphonium chloride|97%
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Quality Control of [ 5034-06-0 ]

COA NMR CNMR HPLC LC-MS

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SDS Specification

Alternatived Products of [ 5034-06-0 ]

Product Details of [ 5034-06-0 ]

CAS No. :	5034-06-0	MDL No. :	MFCD00011898
Formula :	C₃H₉ClOS	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	KQYWHJICYXXDSQ-UHFFFAOYSA-M
M.W :	128.62	Pubchem ID :	197819
Synonyms :

Calculated chemistry of [ 5034-06-0 ]

Physicochemical Properties

Num. heavy atoms :	6
Num. arom. heavy atoms :	0
Fraction Csp3 :	1.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	31.5
TPSA :	36.28 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	No
P-gp substrate :	No
CYP1A2 inhibitor :	No
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-6.28 cm/s

Lipophilicity

Log Po/w (iLOGP) :	0.0
Log Po/w (XLOGP3) :	1.14
Log Po/w (WLOGP) :	-2.62
Log Po/w (MLOGP) :	0.6
Log Po/w (SILICOS-IT) :	-0.46
Consensus Log Po/w :	-0.27

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-1.36
Solubility :	5.67 mg/ml ; 0.0441 mol/l
Class :	Very soluble
Log S (Ali) :	-1.5
Solubility :	4.1 mg/ml ; 0.0319 mol/l
Class :	Very soluble
Log S (SILICOS-IT) :	-0.97
Solubility :	13.8 mg/ml ; 0.107 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.84

Safety of [ 5034-06-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 5034-06-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5034-06-0 ]
Downstream synthetic route of [ 5034-06-0 ]

[ 5034-06-0 ] Synthesis Path-Upstream 1~4

1
[ 29943-42-8 ]
[ 5034-06-0 ]
[ 185-72-8 ]

Reference： [1] Phosphorus and Sulfur and the Related Elements, 1984, vol. 19, p. 113 - 130

2
[ 1774-47-6 ]
[ 5034-06-0 ]

Reference： [1] Journal of the American Chemical Society, 2002, vol. 124, # 14, p. 3636 - 3646
[2] Patent: CN106518812, 2017, A, . Location in patent: Paragraph 0064; 0065; 0066; 0067

3
[ 3086-29-1 ]
[ 5034-06-0 ]

Reference： [1] Patent: US4625065, 1986, A,
[2] Patent: US4625065, 1986, A,

4
[ 35155-66-9 ]
[ 70775-39-2 ]
[ 5034-06-0 ]
[ 73801-71-5 ]

Reference： [1] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1981, p. 3225 - 3233

[ 5034-06-0 ] Synthesis Path-Downstream 1~88

1
[ 124-38-9 ]
[ 5034-06-0 ]
C₄H₈O₃S [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1965,vol. 87,p. 1353 - 1364

2
[ 702-50-1 ]
[ 5034-06-0 ]
dimethyl-oxo-(4,4,7-trimethyl-2,6-dioxo-octyl)-λ⁴-sulfanium betaine [ No CAS ]

Reference： [1]Journal of the Chemical Society. Chemical communications,1972,p. 136 - 137

3
[ 7766-36-1 ]
[ 5034-06-0 ]
[ 4641-49-0 ]

Reference： [1]Chemische Berichte,1965,vol. 98,p. 3712 - 3723

4
[ 5034-06-0 ]
[ 39021-78-8 ]
[ 39021-31-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1972,p. 2611 - 2618

5
[ 5034-06-0 ]
dimethylsulfoxonium methylide*trifluroborane [ No CAS ]

Reference： [1]Journal of the American Chemical Society,1965,vol. 87,p. 1353 - 1364

6
[ 5034-06-0 ]
[ 4461-33-0 ]
Dibenzoylcarbamoylmethylid [ No CAS ]

Reference： [1]Tetrahedron,1973,vol. 29,p. 1983 - 1990

7
[ 5034-06-0 ]
[ 4461-33-0 ]
Dimethyloxosulfoniumbenzoylcarbamoylmethylid [ No CAS ]

Reference： [1]Tetrahedron,1973,vol. 29,p. 1983 - 1990

8
[ 1445-73-4 ]
[ 5034-06-0 ]
[ 67685-99-8 ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 19,p. 113 - 130

9
[ 826-36-8 ]
[ 5034-06-0 ]
[ 83868-59-1 ]

Reference： [1]Phosphorus and Sulfur and the Related Elements,1984,vol. 19,p. 113 - 130

10
[ 50-00-0 ]
[ 5034-06-0 ]
[ 74078-14-1 ]

Reference： [1]Journal of the American Chemical Society,1980,vol. 102,p. 5107

11
[ 50707-39-6 ]
[ 5034-06-0 ]
1-(4-Chloro-benzenesulfonyl)-3-phenyl-azetidine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

12
[ 19871-46-6 ]
[ 5034-06-0 ]
1-Benzenesulfonyl-3-phenyl-azetidine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

13
[ 24395-14-0 ]
[ 5034-06-0 ]
[ 70892-07-8 ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

14
[ 63741-57-1 ]
[ 5034-06-0 ]
2-((Z)-1-Fluoro-2-phenyl-vinyl)-hexanal [ No CAS ]
2-[1-Fluoro-2-phenyl-eth-(Z)-ylidene]-hexanal [ No CAS ]
[ 101560-18-3 ]
2-((Z)-1-Fluoro-2-phenyl-vinyl)-hexane-1,2-diol [ No CAS ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 3977 - 3980

15
[ 41343-12-8 ]
[ 5034-06-0 ]
[ 101560-17-2 ]
(Z)-3-Fluoro-2,4-diphenyl-but-3-ene-1,2-diol [ No CAS ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 3977 - 3980

16
[ 132563-81-6 ]
[ 5034-06-0 ]
2-{(S)-1-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethoxy}-tetrahydro-pyran [ No CAS ]
2-{(R)-1-[(R)-2-(2,4-Difluoro-phenyl)-oxiranyl]-ethoxy}-tetrahydro-pyran [ No CAS ]

Reference： [1]Bulletin of the Chemical Society of Japan,1994,vol. 67,p. 1427 - 1433

17
[ 101560-10-5 ]
[ 5034-06-0 ]
(Z)-3-Fluoro-2-methyl-4-phenyl-but-3-enal [ No CAS ]
(Z)-3-Fluoro-2-methyl-4-phenyl-but-2-enal [ No CAS ]
[ 101560-19-4 ]
(Z)-3-Fluoro-2-methyl-4-phenyl-but-3-ene-1,2-diol [ No CAS ]

Reference： [1]Tetrahedron Letters,1985,vol. 26,p. 3977 - 3980

18
[ 5034-06-0 ]
[ 97401-88-2 ]
1-Benzenesulfonyl-3-p-tolyl-azetidine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

19
[ 5034-06-0 ]
[ 137152-08-0 ]
1-Benzenesulfonyl-3-(4-chloro-phenyl)-azetidine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

20
[ 5034-06-0 ]
[ 83697-47-6 ]
[ 108257-03-0 ]
[ 108257-03-0 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1986,p. 1297 - 1302

21
[ 5034-06-0 ]
[ 40031-60-5 ]
[ 114988-29-3 ]
[ 114988-29-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1986,p. 1297 - 1302
[2]Journal of the Chemical Society. Perkin transactions I,1986,p. 1297 - 1302

22
[ 5034-06-0 ]
[ 40031-60-5 ]
[ 114988-29-3 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1986,p. 1297 - 1302

23
[ 5034-06-0 ]
[ 85858-09-9 ]
[ 85858-10-2 ]
[ 85858-10-2 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1983,p. 395 - 402

24
[ 5034-06-0 ]
[ 80963-70-8 ]
[ 80963-76-4 ]

Reference： [1]Journal of the American Chemical Society,1982,vol. 104,p. 2079 - 2081

25
[ 5034-06-0 ]
[ 80963-70-8 ]
[ 91793-76-9 ]

Reference： [1]Journal of Organic Chemistry,1985,vol. 50,p. 4072 - 4080

26
[ 5034-06-0 ]
2-Methyl-1-(4'-methyl-biphenyl-4-sulfonyl)-aziridine [ No CAS ]
3-Methyl-1-(4'-methyl-biphenyl-4-sulfonyl)-azetidine [ No CAS ]

Reference： [1]Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry,1993,vol. 32,p. 297 - 298

27
[ 5034-06-0 ]
[ 156944-32-0 ]
(R)-2-(2,4-Difluoro-phenyl)-2-((S)-1-methoxy-ethyl)-oxirane [ No CAS ]
(R)-2-(2,4-Difluoro-phenyl)-2-((R)-1-methoxy-ethyl)-oxirane [ No CAS ]

Reference： [1]Bulletin of the Chemical Society of Japan,1994,vol. 67,p. 1427 - 1433

28
[ 5034-06-0 ]
[ 133825-95-3 ]
erythro-2-(2,4-difluorophenyl)-2-<1-(methylthio)ethyl>oxirane [ No CAS ]
threo-2-(2,4-difluorophenyl)-2-<1-(methylthio)ethyl>oxirane [ No CAS ]

Reference： [1]Bulletin of the Chemical Society of Japan,1994,vol. 67,p. 1427 - 1433

29
[ 5034-06-0 ]
[ 70775-39-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium hydride; In tetrahydrofuran; for 4h;Heating / reflux;	Preparation of dimethylsulfoxonium ylide To a 100 ml 3 necked round bottom flask was added 5.00 g (38.9 mmol) of <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> and 38.9 mL of THF. The solution was placed under nitrogen, then 5.72 g (42.8 mmol) of 30 weight percent potassium hydride was added to the flask. The solution was heated under reflux for 4 hours then filtered. No rinses with THF were done to maintain an approximately 1 M stock solution of the ylide.
	With potassium tert-butylate; In tetrahydrofuran; at 65℃; for 2h;Inert atmosphere;	Trimethylsulfoxonium chloride (26.1 g, 198 mmol), THE (202 mL), and potassium tert-butoxide (23.4 g, 202 mmol) were added to a 500 mL jacketed flask under a nitrogen blanket. The suspension was stirred for about 2 h at about 65 C. before being cooled to about 0 C. In a separate flask, (1S,2R,4S)-4-(dibenzylamino)-2-methylcyclopentanecarboxylic acid (21.4 g, 66.2 mmol, WO2011/068881) was dissolved in THF (134 mL), HATU (31.4 g, 83 mmol) and TEA (11.5 mL, 83 mmol) were added and the solution was mixed for about 4 h. With the sulfur ylide suspension maintained between about 0 and -5 C., the activated ester solution was filtered and then added dropwise over about 3 h to the ylide suspension. The resulting bright yellow suspension was stirred for about 8 h at about 5 C. Water (340 mL) and THF (30 mL) were added, and the mixture stirred for about 30 min at about 25 C. Aqueous sodium chloride (15%, 60 mL) was added to the solution and the layers separated. The aqueous layer was extracted with EtOAc (60 mL). The combined organic layers were washed with aqueous NaCl (15%, 3×100 mL). The solution was concentrated and the crude oil was dissolved in methanol (150 mL) and water (150 mL) was added to the slurry which was stirred for about 1 h at ambient temperature before being cooled to about 10 C. and stirred overnight. The white solid was filtered and washed with chilled 1:1 MeOH/water (20 mL) and water (60 mL). The solid was dried in the vacuum oven to afford (1S,2R,4S)-2-(2-methyl-4-(dibenzylamino)cyclopentyl)-dimethylsulfoxonium-2-oxo-ethylide (23.8 g, 90%).

Reference： [1]Journal of the American Chemical Society,2002,vol. 124,p. 3636 - 3646
[2]Tetrahedron,1984,vol. 40,p. 1215 - 1224
[3]Journal of the Chemical Society. Perkin transactions I,1983,p. 2645 - 2648
[4]Journal of the Chemical Society. Perkin transactions I,1983,p. 395 - 402
[5]Tetrahedron,1993,vol. 49,p. 8343 - 8358
[6]Gazzetta Chimica Italiana,1984,vol. 114,p. 93 - 102
[7]Synlett,2007,p. 633 - 637
[8]Patent: WO2006/61711,2006,A1 .Location in patent: Page/Page column 20
[9]European Journal of Organic Chemistry,2012,p. 114 - 118
[10]Patent: US2013/72470,2013,A1 .Location in patent: Paragraph 0369; 0370
[11]Tetrahedron Letters,2018,vol. 59,p. 3777 - 3781
[12]Drugs of the Future,2019,vol. 44,p. 265 - 275

30
[ 33877-04-2 ]
[ 5034-06-0 ]
[ 900254-26-4 ]

Yield	Reaction Conditions	Operation in experiment
		2g sodium hydride and 22g <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> are suspended in ~50ml DMSO and after gas evolution has deceased 11.5g of the above 3-methoxycinnamic acid ethyl ester in 20 ml DMSO/THF are added. After stirring for several days, 1 N HCI is added under ice cooling and the mixture is extracted with diethylether. The combined organic phases are dried over MgSO4 and the solvent removed. This crude product is used without further purification.
		2 g sodium hydride and 22 g <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> are suspended in -50 ml DMSO and after gas evolution has deceased 11.5 g of the above 3-methoxycinnamic acid ethyl ester in 20 ml DMSO/THF are added. After stirring for several days, 1N HCl is added under ice cooling and the mixture is extracted with diethylether. The combined organic phases are dried over MgSO4 and the solvent removed. This crude product is used without further purification.

Reference： [1]Patent: WO2008/20045,2008,A1 .Location in patent: Page/Page column 188
[2]Patent: US2008/260749,2008,A1 .Location in patent: Page/Page column 64

31
[ 5392-11-0 ]
[ 5034-06-0 ]
[ 368833-57-2 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium iodide; In dimethyl sulfoxide; mineral oil;	PREPARATION 21 6-Methoxy-3-methyl-1,1a,3,7b-tetrahydro-3-aza-cyclopropa[a]naphthalen-2-one A suspension of 7.0 gm (42.0 mmol) potassium iodide and 4.89 gm (38.0 mmol) <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> in 30 ml of DMSO under nitrogen was treated portionwise with 1.69 gm (42.0 mmol) of 60percent sodium hydride in mineral oil. The mixture was stirred for one hour and then treated with 2.0 gm (11.0 mmol) 6-Methoxy-1-methyl-1H-quinolin-2-one followed by stirring for 0.5 hours at ambient temperature and 4 days at 90° C. The reaction mixture was allowed to cool to ambient temperature before quenching into ice followed by extraction into ether. The ether layer was washed with brine, dried over sodium sulfate and evaporated. The residue was partitioned between acetonitrile and pentane. The acetonitrile layer was concentrated. The residue was partitioned between 1:1 hexane/ethyl acetate and 50percent saturated (sat'd) brine solution. The organic layer was washed with saturated brine, dried over sodium sulfate and evaporated in vacuo to afford 1.6 gm of a mixture of desired product and starting material. The residue was purified by silica gel chromatography eluding with 7/3 hexane/ethyl acetate to afford 972 mg (44percent). Mass spectrum APCI m/e 204 (p+1).

Reference： [1]Patent: US2003/87925,2003,A1

32
[ 5034-06-0 ]
[ 133825-95-3 ]
threo-2-(2,4-difluorophenyl)-2-(1-methylthioethyl)oxirane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With sodium hydroxide; In dichloromethane; water;	EXAMPLE 3 To 2-methylthio-2',4'-difluoropropiophenone (0.43 g), there were added dichloromethane (4.5 g) and <strong>[5034-06-0]trimethyloxosulfonium chloride</strong> (0.38 g) under a nitrogen stream, and 50 percent aqueous sodium hydroxide solution (8.0 g) was added thereto at room temperature. The resultant mixture was kept at the same temperature while stirring for 2 hours. Upon confirmation of the disappearance of 2-methylthio-2',4'-difluoropropiophenone by HPLC, the reaction mixture was combined with water (50 ml) and dichloromethane (50 ml) for extraction. The aqueous layer was separated from the dichloromethane layer and extracted with dichloromethane (30 ml). The dichloromethane extract was combined with the dichloromethane layer and washed with water (100 ml) twice. The dichloromethane layer was dried over magnesium sulfate and concentrated to dryness to give 0.45 g of threo-2-(2,4-difluorophenyl)-2-(1-methylthioethyl)oxirane as an oil.

Reference： [1]Patent: US5159089,1992,A

33
[ 139297-65-7 ]
[ 5034-06-0 ]
2-(1-chloro-cycloprop-1-yl)-2-(2'-chloro-benzyl)-oxirane [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
87.3%	With sodium hydroxide; In water; toluene;	EXAMPLE 31 STR51 507 g (5.7 mol) of 45percent strength by weight aqueous sodium hydroxide solution are added dropwise to a suspension of 171.0 g (0.75 mol) of 2-chlorobenzyl 1-chlorocyclopropyl ketone and 104.0 g (0.81 mol) of trimethylsulphoxonium chloride in 1000 ml of toluene at 20° C., while stirring. During this procedure, the temperature of the reaction mixture rises up to 32° C. When the addition has ended, the reaction mixture is stirred at 30° C. for a further 4 hours, and 600 ml of water are then added, while cooling. The organic phase is separated off and the aqueous phase is extracted twice more with toluene. After drying over magnesium sulphate, the combined organic phases are concentrated under reduced pressure. 175.6 g of an oily product which consists of 2-(2-chlorobenzyl)-(1-chloro-cyclopropyl)-oxirane to the extent of 90.5percent are obtained in this manner. The yield is accordingly calculated as 87.3percent of theory.

Reference： [1]Patent: US5146001,1992,A

34
ruthenium(IV) oxide hydrate [ No CAS ]
[ 3086-29-1 ]
[ 5034-06-0 ]

Yield	Reaction Conditions	Operation in experiment
	In water;	EXAMPLE I Preparation of Trimethylsulfoxonium Chloride A solution of 50percent trimethylsulfonium chloride in water was prepared, and to 5 grams (g) of this solution was added 0.05 g of ruthenium dioxide hydrate and 10 milliliters (ml) of water. Thereafter, sodium metaperiodate (4.77 g) was added to the reaction mixture in portions over a period of several hours. A thick slurry of sodium iodate formed, and this mixture was filtered. The filtrate was analyzed by nuclear magnetic resonance (nmr) spectroscopy and was found to contain trimethylsulfoxonium chloride with only a trace (<2percent) of unreacted trimethylsulfonium chloride.
	With sodium hypochlorite; In water;	EXAMPLE II Preparation of Trimethylsulfoxonium Chloride A mixture of 5 g of trimethylsulfonium chloride, 3 g of water, and 3 mg of ruthenium dioxide hydrate was stirred under a chlorine atmosphere. A solution of sodium hypochlorite (11.5percent) in water was added over 5.5 hours. The pH of the mixture remained below 7 throughout the reaction. The aqueous product mixture was extracted three times with chloroform to remove ruthenium tetroxide. Analysis of the product solution by nmr showed 78percent conversion to trimethylsulfoxonium chloride.

Reference： [1]Patent: US4625065,1986,A
[2]Patent: US4625065,1986,A

35
CP [ No CAS ]
[ 1774-47-6 ]
[ 5034-06-0 ]
dimethyloxosulfonium methylide [ No CAS ]
sodium chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With n-butyllithium; In tetrahydrofuran; hexane; dimethyl sulfoxide;	EXAMPLE 13 To 10.2 ml (16.5 mM) of 15percent solution of n-butyllithium in n-hexane, 15 ml of n-hexane, 3.81 g (17.25 mM) of trimethylsulfoxonium iodide and 30 ml of DMSO were added and the mixture was stirred for 30 minutes. This reaction mixture was poured dropwise into a solution of 1.86 g (15 mM) of CP in 15 ml of DMSO in 4 hours. After reacting for two hours at room temperature, the treatments were carried out as described in Example 8. 1.29 g (62percent yield) of a primary product were produced, from which 0.87 g (43percent yield) of sabina ketone were obtained by distillation. Then, 12.85 g (100 mM) of <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> and 150 ml of THF were added to 2.64 g (110 mM) of sodiumm hydride and the mixture was heated under reflux for 4 hours with stirring. After the reaction mixture was cooled, the by-produced sodium chloride was filtered off by using celite as filter aid. A THF solution of dimethylsulfoxonium methylide was obtained. This solution was supplemented to an amount of 200 ml by adding further THF and was stored in a refrigerator under nitrogen atmosphere.

Reference： [1]Patent: US4162258,1979,A

36
[ 5034-06-0 ]
dimethyloxosulfonium methylide [ No CAS ]
sodium chloride [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	In tetrahydrofuran;	EXAMPLE 4 To 2.64 g (110 mM) of sodium hydride 12.85 g (100 mM) of <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> and 150 ml of THF were added and the mixture was heated under reflux for 4 hours with stirring. After cooling the reaction mixture, the by-produced sodium chloride was filtered off using celite as filter aid. A THF solution of dimethylsulfoxonium methylide was obtained. This solution was supplemented to a volume of 200 ml by adding further amount of THF and was stored under nitrogen atmosphere in a refrigerator.
	In tetrahydrofuran;	EXAMPLE 21 12.85 g (100 mM) of <strong>[5034-06-0]trimethylsulfoxonium chloride</strong> and 150 ml of THF were added to 2.64 g (110 mM) of sodium hydride and the mixture was heated under reflux for 4 hours with stirring. After the reaction mixture was cooled, the by-produced sodium chloride was filtered off by employing celite as filter aid. A THF solution of dimethylsulfoxonium methylide was obtained. This solution was supplemented to an amount of 200 ml by adding further THF and was stored in a refrigerator under nitrogen atmosphere.

Reference： [1]Patent: US4162258,1979,A
[2]Patent: US4162258,1979,A

37
[ 868612-22-0 ]
[ 5034-06-0 ]
[ 959936-98-2 ]