Alternatived Products of [ 5043-01-6 ]
Product Details of [ 5043-01-6 ]
CAS No. : | 5043-01-6 |
MDL No. : | MFCD06200717 |
Formula : |
C11H7FO2
|
Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | CYKDCZRPLWJEKA-UHFFFAOYSA-N |
M.W : |
190.17
|
Pubchem ID : | 2782788 |
Synonyms : |
|
Application In Synthesis of [ 5043-01-6 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Upstream synthesis route of [ 5043-01-6 ]
- Downstream synthetic route of [ 5043-01-6 ]
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[ 33627-02-0 ]
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[ 5043-01-6 ]
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[ 32405-50-8 ]
- 2
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[ 7499-66-3 ]
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[ 5043-01-6 ]
- 3
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[ 324-41-4 ]
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[ 5043-01-6 ]
- 4
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[ 79-37-8 ]
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[ 5043-01-6 ]
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[ 13916-91-1 ]
Yield | Reaction Conditions | Operation in experiment |
50% |
In 1,4-dioxane; water; 4-(dicyanomethylene)-2-methyl-6-(p-dimethylaminostyryl)-4H-pyran; N,N-dimethyl-formamide; |
Step 3. The above acid was placed in 100 mL dry DCM with 0.5 mL DMF. To it was added oxalyl chloride (15 mL, 168 mmol) dropwise. The mixture was stirred for overnight. It was concentrated in vacuuo. The dry acid chloride was then dissolved in 200 mL dry dioxane. It was chilled in ice bath and vigorously stirred. To it was dropwise added a cold solution of sodium azide (7.3 g, 112 mmol) in 30 mL water and 30 mL dioxane. The reaction was stirred for 2 hrs. After evaporation in vacuuo, the residue was taken into 300 mL DCM. It was washed with water *3 and then evaporated in vacuuo. The residue was dissolved in 120 mL DMF. To it was added 60 mL water. The mixture was refluxed for 6 hrs. The solvent was removed in vacuuo. The residue was taken into chloroform, washed with water, dried, concentrated in vacuuo to give 6-fluoro-2-naphthylamine (50%). Rf 0.53 (1:1 EtOAc:hexane). ES-MS: (M+H)+162. |
- 5
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[ 5043-01-6 ]
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[ 324-41-4 ]
- 6
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[ 1073182-59-8 ]
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[ 5043-01-6 ]
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methyl 2-chloro-5-(6-fluoro-2-naphthamido)isonicotinate
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
|
With dmap; methanesulfonyl chloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20℃; |
To a stirring suspension of <strong>[1073182-59-8]methyl 5-amino-2-chloroisonicotinate</strong> (200 mg, 1.07 mmol) and 6-fluoro-2-naphthoic acid (245 mg, 1.29 mmol) in DCM (10.7 rriL) was added dropwise methanesulfonyl chloride (0.124 mL, 1.61 mmol). Hunigs base (0.560 rriL, 3.22 mmol) was then added, followed by DMAP (13.1 mg, 0.107 mmol) and the resulting solution was stirred at rt overnight. The solvent was evaporated in vacuo and the residue then re-suspended in DCM and ether. The precipitate was collected via vacuum filtration, washed with ether to furnish the desired material. |
- 7
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[ 1073182-59-8 ]
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[ 5043-01-6 ]
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2-chloro-5-(6-fluoro-2-naphthamido)isonicotinic acid
[ No CAS ]