Alternatived Products of [ 51102-42-2 ]
Product Details of [ 51102-42-2 ]
CAS No. : | 51102-42-2 |
MDL No. : | MFCD09701388 |
Formula : |
C7H14N2
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Boiling Point : |
- |
Linear Structure Formula : | - |
InChI Key : | - |
M.W : |
126.20
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Pubchem ID : | - |
Synonyms : |
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Application In Synthesis of [ 51102-42-2 ]
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
- Downstream synthetic route of [ 51102-42-2 ]
- 1
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[ 190783-99-4 ]
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[ 51102-42-2 ]
Yield | Reaction Conditions | Operation in experiment |
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Multi-step reaction with 5 steps
1: 78 percent / Lawesson's reagent / tetrahydrofuran / 20 °C
2: 95 percent / benzene / 12 h / 20 °C
3: 65 percent / Et3N / dimethylformamide / 24 h / 20 °C
4: 79 percent / HCO2NH4 / Pd-C / methanol / Heating
5: 77 percent / LAH / tetrahydrofuran / 6 h / Heating |
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Reference:
[1]Singh, Rakesh K.; Jain, Sanjay; Sinha, Neelima; Mehta, Anita; Naqvi, Fehmida; Agarwal, Ashok K.; Anand, Nitya
[Tetrahedron Letters, 2007, vol. 48, # 4, p. 545 - 548]
- 2
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[ 17973-86-3 ]
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[ 51102-42-2 ]
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[ 884856-73-9 ]
Yield | Reaction Conditions | Operation in experiment |
41% |
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Method A3-(6-Bromo-pyridazin-3-yl)-delta-methyl-3.delta-diaza-bicvclor3.2.1loctane fumaric acid salt(Intermediate compound)A mixture of delta-methyl-3,delta-diazabicyclo[3.2.1]octane (2.0 g; 15.65 mmol), <strong>[17973-86-3]3,6-dibromopyridazine</strong> (3.77 g; 15.65 mmol) and dioxane (20 ml) was stirred at room temperature for 15 hours. Aqueous sodium hydroxide (1 M; 20 ml) was added and the EPO <DP n="22"/>mixture was extracted twice with dichloromethane (2 x 20 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the compound as free base. Yield 1.83 g (41%). The corresponding salt was obtained by addition of a diethyl ether and methanol mixture (9:1 ) saturated with fumaric acid. Mp. 118.5-119.5C. |
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Method C; 3-(6-Bromo-pyridazin-3-yl)- delta-methyl-S.delta-diaza-bicvclobeta^.iloctane free base(Intermediate compound); A mixture of 3,6-dibromoyridazine (13.0 g, 54.6 mmol), 8-methyl-3,8-diaza-20 bicyclo[3.2.1]octane (6.9 g, 54.6 mmol) and dioxane (100 ml) was stirred at room temperature for 15 hours followed by 70C for 12 hours. Aqueous sodium hydroxide (1M, 100 ml) was added and the mixture was extracted twice with dichloromethane (2 x 100 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the compound as a crystalline solid. Mp. 118.5-25 119.5C. |
- 3
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[ 29969-57-1 ]
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[ 51102-42-2 ]
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2-(8-methyl-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
35% |
With N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; for 15h;Heating / reflux; |
Method A; 2-(8-Methyl-3,8-diaza-bicyclo[3.2.1]oct-3-yl)-6-nitro-quinoline free base; A mixture of 8-methyl-3,8-diazabicyclo[3.2.1]octane (3.8 g, 30 mmol), 2-chloro-6- nitroquinoline (6.2 g, 30 mmol), diisopropylethylamine (10.5 ml, 60 mmol) and dioxane (100 ml) was stirred at reflux for 15 h. Aqueous ammonia (50 ml, 1 M) was added followed by extraction with dichloromethane (3 x 50 ml). Chromatography on silica gel with methanol : dichloromethane : aqueous ammonia (1 : 9 : 1%) as solvent gave the title compound as a solid. Yield 3.1g (35%). Mp 152.1-154.5C. |
- 4
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[ 20375-65-9 ]
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[ 51102-42-2 ]
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8-methyl-3-(6-phenyl-pyridazin-3-yl)-3,8-diaza-bicyclo[3.2.1]octane
[ No CAS ]
Yield | Reaction Conditions | Operation in experiment |
68% |
|
Method A; 15 8-Methyl-3-(6-phenyl-pyridazin-3-yl)-3.8-diaza-bicvclor3.2.1loctane free base(Compound A1 ); A mixture of 8-methyl-3,8-diaza-bicyclo[3.2.1]octane (2.0 g, 15.8 mmol) and<strong>[20375-65-9]3-chloro-6-phenylpyridazine</strong> (3.0 g, 15.8 mmol) was stirred at 120C for 2.5 hours.Aqueous sodium hydroxide (1 M, 50 ml) was added and the mixture was extracted 20 twice with dichloromethane (2 x 50 ml). Chromatography on silica gel with dichloromethane, 10% methanol and 1% aqueous ammonia as solvent gave the title compound as a crystalline solid. Yield 1.5 g (68%). Mp. 151C. |