516455-57-5|1-(1H-Benzo[d]imidazol-2-yl)-3-methyl-1H-pyrazol-5-ol| Ambeed

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Yield	Reaction Conditions	Operation in experiment
	In acetic acid; at 20℃; for 2h;	General procedure: A mixture of 2-hydrazino-5-methyl-benzimidazole (3, 1.0g, 6.17mmol) and ethyl 2-acetyl-3-phenylpropanoate (4, 1.4mL, 6.59mmol) in acetic acid (20mL) was stirred for 2h at ambient temperatures. To a mixture of acetonitrile (100mL) and water (100mL) was added the reaction mixture. After stirring at ambient temperatures, the resulting precipitates were collected by filtration and washed with acetonitrile in water (1:1). The precipitates was purified by recrystallization from ethanol (95mL) to generate 3-methyl-1-(5-methyl-1H-benzimidazol-2-yl)-4-benzyl-1H-pyrazol-5-ol (35, 0.64g, 32.6%). The other compounds studied in this work (5-52) were prepared in a similar manner. The typical experimental procedure for synthesizing and evaluating the compounds used in this study, in addition to the analytical data and the estimated purity (HPLC) of the biologically relevant compounds, are provided in Supplemental data and Table S1, respectively.

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Physical hazards
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H200	Unstable explosive
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Health hazards
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Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

CAS No. :	516455-57-5	MDL No. :	MFCD03759867
Formula :	C₁₁H₁₀N₄O	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	RRXNULSELUJDDO-UHFFFAOYSA-N
M.W :	214.22	Pubchem ID :	719005
Synonyms :

Signal Word:	Warning	Class:
Precautionary Statements:	P501-P270-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330	UN#:
Hazard Statements:	H302-H315-H319	Packing Group:
GHS Pictogram:

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[ 516455-57-5 ] Synthesis Path-Downstream 1~1

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