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Chemical Structure| 516465-99-9 Chemical Structure| 516465-99-9

Structure of 516465-99-9

Chemical Structure| 516465-99-9

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Product Details of [ 516465-99-9 ]

CAS No. :516465-99-9
Formula : C16H17NO4
M.W : 287.31
SMILES Code : O=C(C1=CC=C2C=C(NC(OC(C)(C)C)=O)C=CC2=C1)O
MDL No. :MFCD24465838

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Application In Synthesis of [ 516465-99-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 516465-99-9 ]

[ 516465-99-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 24424-99-5 ]
  • [ 116668-47-4 ]
  • [ 516465-99-9 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; NaOH; In water; tert-butyl alcohol; Example 4.1Synthesis of 6-(tert-butoxycarbonylamino)-2-naphthoic acid (7)Boc2O (280 mg, 1.28 mmol) and NaOH (40 mg, 1.0 mmol) were added to a solution of <strong>[116668-47-4]6-amino-2-naphthoic acid</strong> (200 mg, 1.07 mmol) in t-BuOH (6 mL) and H2O (6 mL).The reaction mixture was stirred at room temperature for 12 hours, after which it was diluted with water and washed with CH2Cl2.The aqueous layer was adjusted to a pH level of about 2 with 2N HCl and extracted with ethyl acetate.The organic layer was dried over Na2SO4, and the filtrate was concentrated and purified by silica column chromatography (ethyl acetate/hexane=1/1) (300 mg, 98percent).1H-NMR (CD3OD) 8.48 (s, 1H), 8.05 (s, 1H), 7.95 (d, J=8.4, 1H), 7.86 (d, J=8.7, 1H), 7.75 (d, J=8.7, 1H), 7.51 (d, J=8.8, 1H) 1.53 (s, 9H) ppm; ESI-MS m/z calcd for C16H17N2O: 287.3105. found 288.8273 [M+1].
 

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