Hesperetin | UGT Inhibitor

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

CAS No. :	520-33-2
Formula :	C₁₆H₁₄O₆
M.W :	302.28
SMILES Code :	O=C1C[C@H](OC2=C1C(O)=CC(O)=C2)C3=CC=C(C(O)=C3)OC
Synonyms :	NSC 57654; (–)-3',5,7-Trihydroxy-4'-methoxyflavanone; Prestwick_908
MDL No. :	MFCD00075646
InChI Key :	AIONOLUJZLIMTK-AWEZNQCLSA-N
Pubchem ID :	72281

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

HeLa cells	100 µM	1 hour	To study the effect of hesperetin on the binding of TGF-β1 to TβRII, results showed that hesperetin reduced the probability of ligand-receptor binding.	PMC3513570
Lewis lung carcinoma (LLC) cells	30 μM	1 hour	To evaluate the protective effect of hesperetin against acrolein-induced toxicity in LLC cells. Results showed that hesperetin pretreatment significantly increased cell viability and reduced the expression of apoptosis marker proteins (e.g., cleaved caspase-3, cleaved PARP, cytochrome C, and p-p53).	PMC6748696
HeLa cells	100 µM	24 hours	To study the effect of hesperetin on TGF-β1-induced cell migration, results showed that hesperetin inhibited cell migration capacity.	PMC3513570
SH-SY5Y AßPPwt cells	0.01–10 µM	24 hours	To evaluate the antioxidant capacity and changes in ATP levels of hesperetin nanocrystals in an Alzheimer’s disease cell model. Results showed that hesperetin nanocrystals significantly increased ATP levels, with more pronounced effects observed in 170 nm nanocrystals.	PMC7987607
HEK293-CISD2 reporter cells	10-30 μM	24 hours	Screening for CISD2 activators via luciferase reporter assay, hesperetin enhances CISD2 expression	PMC9310407
Human aortic valve interstitial cells (VICs)	3 μM	24 hours	Hesperetin pretreatment inhibited LPS-induced NF-κB inflammatory cytokine secretion and osteogenic factor expression, reduced ROS production and apoptosis, and abrogated LPS-mediated injury to the mitochondrial membrane potential and the decline in antioxidant levels in VICs.	PMC9687039
SH-SY5Y-MOCK cells	0.01 to 10 µM	24 hours	The effects of HstN on SY5Y-MOCK control cells were relatively small. HstP had almost no effect on both cell lines.	PMC8300699
SH-SY5Y-APP695 cells	0.01 to 10 µM	24 hours	HstN significantly reduced mitochondrial dysfunction: ATP levels and respiratory chain complex activity significantly increased. Gene expression levels of RCC I, IV, and V were significantly upregulated. HstP had almost no effect on both cell lines.	PMC8300699
AGS cells	0, 6.25, 12.5, 25, 50 μM	24 hours	To evaluate the effect of hesperetin on the translocation of CagA and VacA proteins into AGS cells infected with H. pylori. Results showed that hesperetin treatment significantly reduced the translocation of CagA and VacA proteins.	PMC8472136
THP-1 macrophages	0–40 μg/mL	24 hours	Evaluate the inhibitory effect of Hesperetin on Spike S1-induced inflammatory responses, significantly reducing the release of IL-6, IL-1β, and IL-18	PMC9498987
A549 lung cells	0–40 μg/mL	24 hours	Evaluate the inhibitory effect of Hesperetin on Spike S1-induced inflammatory responses, significantly reducing the release of IL-6, IL-1β, and IL-18	PMC9498987
HT-22 cells	50 μM	24 hours	To evaluate the effect of hesperetin on LPS-induced cytotoxicity and ROS/LPO. Hesperetin significantly reduced LPS-induced cytotoxicity and ROS/LPO levels.	PMC6471991
BV2 cells	50 μM	24 hours	To evaluate the effect of hesperetin on LPS-induced TLR4 and Iba-1 protein expression. Hesperetin significantly reduced LPS-induced TLR4 and Iba-1 protein levels.	PMC6471991
HEK001-shCISD2 cells	10 μM	48 hours	In CISD2 knockdown cells, hesperetin loses its beneficial effects on mitochondrial function and antioxidant capacity	PMC10807130
HEK001 human keratinocytes	10 μM	48 hours	Enhances mitochondrial function and protects against ROS-induced oxidative stress via increased CISD2 expression	PMC10807130
H226 cells	75, 150, 300 µM	48 hours	To evaluate the effect of HST on the viability of H226 cells, results showed that HST inhibited cell viability in a concentration- and time-dependent manner, induced G2/M phase cell cycle arrest and apoptosis.	PMC11936485
H1703 cells	37.5, 75, 150 µM	48 hours	To evaluate the effect of HST on the viability of H1703 cells, results showed that HST inhibited cell viability in a concentration- and time-dependent manner, induced G2/M phase cell cycle arrest and apoptosis.	PMC11936485
HepG2 cells	20 μM and 40 μM	4-hour pretreatment followed by 24-hour PA stimulation	To investigate the inhibitory effect of hesperetin on PA-induced cell death and NLRP3 inflammasome activation in HepG2 cells. Results showed that hesperetin significantly increased cell viability, reduced cell death, and inhibited PA-induced IL-1β and IL-18 mRNA expression and NLRP3 and caspase-1 protein expression.	PMC11181321
A549/DDP cells	0.6, 1.25, 2.5, 5, 10 µM	72 hours	Assessed the toxic effects of hesperetin on A549/DDP cells and its synergistic effect with cisplatin; concentrations ≥2.5 µM significantly enhanced the cytotoxicity of DDP	PMC7053858
Human lung adenocarcinoma A549 cells	0.6, 1.25, 2.5, 5, 10, 20, 40, 80, 160 µM	72 hours	Evaluated the toxic effects of hesperetin on A549 cells; low concentrations (<5 µM) had no significant effect, while higher concentrations (>20 µM) significantly inhibited cell proliferation	PMC7053858

Mice	Naturally aged mouse model	Oral	100 mg/kg/day	Continued for 3-6 months	Hesperetin extends healthspan, ameliorates age-related metabolic decline, body composition changes, glucose dysregulation, and organ senescence	PMC9310407
Mice	Naturally aged mice	Oral	100 mg/kg/day	Once daily for 5 months	Enhances CISD2 expression, improves skin aging phenotypes, and reduces ROS levels	PMC10807130
Nude mice	A549/DDP xenograft model	Intragastric administration	2 mg/kg	Every 2 days for 52 days	Evaluated the inhibitory effect of hesperetin on A549/DDP cell growth in vivo; hesperetin pretreatment significantly inhibited tumor growth	PMC7053858
BALB/c nude mice	H226 xenograft model	Intraperitoneal injection	30, 60, 90 mg/kg	Once every 2 days for 28 days	To evaluate the anti-tumor effect of HST on H226 xenograft tumors, results showed that HST significantly inhibited tumor growth without apparent toxic side effects.	PMC11936485
C57BL/6 mice	Direct wire injury (DWI)-induced aortic valve stenosis model	Oral gavage	50 mg/kg	Once daily for 7 days	Hesperetin supplementation protected mice from wire-injury-induced aortic valve stenosis; in vivo, hesperetin corrected dysfunctional mitochondria by activating the Nrf2-ARE signaling pathway.	PMC9687039
C57BL/6N mice	LPS-induced neuroinflammation model	Oral gavage	50 mg/kg	Daily for a total of five weeks	To evaluate the effect of hesperetin on LPS-induced neuroinflammation, oxidative stress, and memory impairments. Hesperetin significantly reduced LPS-induced neuroinflammation, oxidative stress, and memory impairments.	PMC6471991
C57BL/6 mice	Acrolein-induced lung injury model	Intraperitoneal injection	60 mg/kg	Single dose, lasting 12 hours	To investigate the protective effects of hesperetin on acrolein-induced lung damage. Results showed that hesperetin pretreatment significantly improved lung tissue structure, reduced fibrosis and apoptosis marker protein expression, and decreased oxidative stress markers (e.g., Prx-SO3, HNE, and 8-OH-dG).	PMC6748696
Sprague Dawley rats	High-fat diet and streptozotocin (STZ)-induced type 2 diabetes rat model	Oral gavage	Hesperetin 50 mg/kg/day, Metformin 100 mg/kg/day	Once daily for six weeks	To investigate the effect of hesperetin-enhanced metformin on alleviating cognitive impairment in diabetic rats and its mechanism	PMC11900253

{[proInfo.proName]}

CAS No.: 520-33-2

{[proInfo.proName]}

CAS No.: 520-33-2

Alternative Products

Product Details of Hesperetin

Safety of Hesperetin

Isoform Comparison

Biological Activity

Protocol

References

Historical Records

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed