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[ CAS No. 52010-22-7 ]

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Cat. No.: {[proInfo.prAm]}
2D
Chemical Structure| 52010-22-7
Chemical Structure| 52010-22-7
Structure of 52010-22-7 *Storage: {[proInfo.prStorage]}

Quality Control of [ 52010-22-7 ]

Purity: {[proInfo.showProBatch.pb_purity]}

Related Doc. of [ 52010-22-7 ]

SDS

Product Details of [ 52010-22-7 ]

CAS No. :52010-22-7MDL No. :MFCD01718133
Formula : C8H5ClO2 Boiling Point : 360.6°C at 760 mmHg
Linear Structure Formula :-InChI Key :-
M.W :168.58Pubchem ID :3040300
Synonyms :

Computed Properties of [ 52010-22-7 ]

TPSA : - H-Bond Acceptor Count : -
XLogP3 : - H-Bond Donor Count : -
SP3 : - Rotatable Bond Count : -

Safety of [ 52010-22-7 ]

Signal Word:WarningClassN/A
Precautionary Statements:P261-P305 P351 P338UN#:N/A
Hazard Statements:H302-H315-H319-H335Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 52010-22-7 ]

  • Downstream synthetic route of [ 52010-22-7 ]

[ 52010-22-7 ] Synthesis Path-Downstream   1~10

  • 1
  • diazotized 4-amino-phthalide [ No CAS ]
  • [ 52010-22-7 ]
  • 3
  • [ 1013915-44-0 ]
  • [ 52010-22-7 ]
  • [ 70097-45-9 ]
  • 4
  • [ 7499-08-3 ]
  • [ 52010-22-7 ]
  • [ 19482-16-7 ]
  • 5
  • [ 7499-08-3 ]
  • [ 6245-57-4 ]
  • [ 4741-62-2 ]
  • [ 52010-22-7 ]
  • 3,3'-dimethoxy-5,5'-dimethyl-1,1'-biphenyl [ No CAS ]
  • [ 19482-16-7 ]
  • 3-chloro-3'-methoxy-2,5'-dimethyl-1,1'-biphenyl [ No CAS ]
  • 6
  • 3-chloro-2-hydroxymethylbenzoic acid [ No CAS ]
  • [ 52010-22-7 ]
YieldReaction ConditionsOperation in experiment
12 g With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20℃; for 2h; To a solution of 3-chloro-2-formylbenzoic acid (24 g, 91.0 mmol) in methanol (250 mL) was added NaBH4 (5.14 g, 136 mmol). The reaction was stirred at ambient temperature for 2 h. The mixture was concentrated to dryness to provide 3-chloro-2-(hydroxymethyl)benzoic acid as a yellow oil. To the oil in THF (80 mL) was added hydrogen chloride in dioxane (6N, 20 mL). The mixture was stirred at ambient temperature for 2 h and then extracted with EtOAc (3*50 mL). The combined organic phase was dried over sodium sulfate, filtered and the filtrate was concentrated in vacuo. The residue was purified by flash chromatography (PE/EtOAc=5/1) to provide <strong>[52010-22-7]4-chloroisobenzofuran-1(3H)-one</strong> (12 g) as a yellow solid. MS (ESI) m/z=169 [M+H]+.
  • 7
  • [ 52010-22-7 ]
  • (S)-tert-butyl ((4-chloro-1,3-dihydroisobenzofuran-1-yl)methyl)(methyl)carbamate [ No CAS ]
  • 8
  • [ 52010-22-7 ]
  • (R)-1-(4-chloro-1,3-dihydroisobenzofuran-1-yl)-N-methylmethanamine hydrochloride [ No CAS ]
  • 9
  • [ 52010-22-7 ]
  • (S)-1-(4-chloro-1,3-dihydroisobenzofuran-1-yl)-N-methylmethanamine hydrochloride [ No CAS ]
  • 10
  • [ 52010-22-7 ]
  • tert-butyl (R)-((4-chloro-1,3-dihydroisobenzofuran-1-yl)methyl)(methyl)carbamate [ No CAS ]
Historical Records

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[ 52010-22-7 ]

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Related Parent Nucleus of
[ 52010-22-7 ]

Benzofurans

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