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CAS No. : | 523-50-2 | MDL No. : | MFCD00064930 |
Formula : | C11H6O3 | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | XDROKJSWHURZGO-UHFFFAOYSA-N |
M.W : | 186.16 | Pubchem ID : | 10658 |
Synonyms : |
Isopsoralen;Bakuchicin;NSC 404563
|
Chemical Name : | 2H-Furo[2,3-h]chromen-2-one |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P261-P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H302-H315-H319-H335 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
95% | With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 90℃; for 1.0h;Inert atmosphere; | General procedure: The appropriate precursors 9 or 10 (1.00 mmol) were dissolved in toluene (10 mL) andprecatalyst A (42 mg, 0.05 mmol, 5 mol %) was added. The mixture was heated to 90 C untilS10TLC indicated complete conversion (ca. 1 h), cooled to ambient temperature and evaporatedin vacuo. The residue was purified by column chromatography on silica using hexanes-MTBEmixtures of increasing polarity as eluents to furnish the products 3 or 11, respectively. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
47% | With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In N,N-dimethyl-formamide at 80℃; for 16h; Schlenk technique; Sealed tube; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34% | With tris[2-phenylpyridinato-C2,N]iridium(III); potassium carbonate In dimethyl sulfoxide at 20℃; for 12h; Schlenk technique; Irradiation; Inert atmosphere; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
36% | With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane; tert-butyl methyl ether at 80℃; for 96h; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
54% | With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium acetate In dimethyl sulfoxide at 45℃; for 24h; Inert atmosphere; Irradiation; regioselective reaction; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
55% | With Bromoeosine; potassium carbonate In dimethyl sulfoxide at 20℃; for 12h; Inert atmosphere; Irradiation; Schlenk technique; | |
55% | With potassium carbonate; Eosin In dimethyl sulfoxide at 25℃; for 12h; Irradiation; | 22 Synthesis of Compound (I-22) Isopsoralen 0.1mmol, iodine ylide 0.15mmol,Eosin Y 0.002mmol, potassium carbonate 0.1mmol were added to the reaction tube,Soluble in dimethyl sulfoxide solvent, 25,The reaction was carried out under LED illumination for 12 hours, and the target product (I-22) was obtained by column chromatography, and the isolated yield was 55%. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With 2,4,6-triisopropylbenzenethiol In tetrahydrofuran at 20℃; for 24h; Irradiation; Inert atmosphere; Schlenk technique; regioselective reaction; |