[ CAS No. 523-50-2 ]

Name: 523-50-2|2H-Furo[2,3-h]chromen-2-one|98%
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{[proInfo.proName]} (Synonyms:Angelicin) ,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

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3d Animation Molecule Structure of 523-50-2

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Quality Control of [ 523-50-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 523-50-2 ]

SDS Specification

Alternatived Products of [ 523-50-2 ]

Product Details of [ 523-50-2 ]

CAS No. :	523-50-2	MDL No. :	MFCD00064930
Formula :	C₁₁H₆O₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	XDROKJSWHURZGO-UHFFFAOYSA-N
M.W :	186.16	Pubchem ID :	10658
Synonyms :	Angelicin

Calculated chemistry of [ 523-50-2 ]

Physicochemical Properties

Num. heavy atoms :	14
Num. arom. heavy atoms :	13
Fraction Csp3 :	0.0
Num. rotatable bonds :	0
Num. H-bond acceptors :	3.0
Num. H-bond donors :	0.0
Molar Refractivity :	52.26
TPSA :	43.35 Å²

Pharmacokinetics

GI absorption :	High
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-5.96 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.03
Log Po/w (XLOGP3) :	2.08
Log Po/w (WLOGP) :	2.54
Log Po/w (MLOGP) :	1.48
Log Po/w (SILICOS-IT) :	2.91
Consensus Log Po/w :	2.21

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	1.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-2.99
Solubility :	0.19 mg/ml ; 0.00102 mol/l
Class :	Soluble
Log S (Ali) :	-2.62
Solubility :	0.447 mg/ml ; 0.0024 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-4.5
Solubility :	0.00587 mg/ml ; 0.0000316 mol/l
Class :	Moderately soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	1.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	3.07

Safety of [ 523-50-2 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 523-50-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 523-50-2 ]

[ 523-50-2 ] Synthesis Path-Downstream 1~68

1
3t-(4-hydroxy-benzofuran-5-yl)-acrylic acid [ No CAS ]
[ 523-50-2 ]

Reference： [1]Proceedings - Indian Academy of Sciences, Section A,1937,p. 148,152
[2]Proceedings - Indian Academy of Sciences, Section A,1937,p. 148,152

2
[ 59292-71-6 ]
[ 127-09-3 ]
[ 108-24-7 ]
[ 523-50-2 ]

Reference： [1]Rasayanam,1936,vol. 1,p. 1,14

3
[ 59292-71-6 ]
[ 523-50-2 ]

Reference： [1]Rasayanam,1936,vol. 1,p. 1,14

4
[ 523-50-2 ]
[ 623-11-0 ]
[ 77-78-1 ]
[ 1449-53-2 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966

5
[ 523-50-2 ]
[ 77-78-1 ]
[ 1449-53-2 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966

6
[ 523-50-2 ]
3t-(4-hydroxy-benzofuran-5-yl)-acrylic acid [ No CAS ]

Reference： [1]Proceedings - Indian Academy of Sciences, Section A,1937,p. 148,152

7
[ 523-50-2 ]
[ 1001206-83-2 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966

8
[ 523-50-2 ]
[ 31231-46-6 ]

Reference： [1]Proceedings - Indian Academy of Sciences, Section A,1942,p. 151,154

9
[ 523-50-2 ]
5A,5b,12b,12c-tetrahydro-difuro[2,3-h;2',3'-h']cyclobuta[1,2-c;4,3-c'] dichromium ene-5,6-dione [ No CAS ]

Reference： [1]Monatshefte fur Chemie,1955,vol. 86,p. 430,432

10
[ 523-50-2 ]
5A,5b,12a,12b-tetrahydro-difuro[2,3-h;2',3'-h']cyclobuta[1,2-c;3,4-c'] dichromium ene-5,12-dione [ No CAS ]

Reference： [1]Monatshefte fur Chemie,1955,vol. 86,p. 430,432
[2]Monatshefte fur Chemie,1955,vol. 86,p. 430,432

11
[ 119658-44-5 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,1958,vol. 4,p. 256,270
[2]Magnetic Resonance in Chemistry,1985,vol. 23,p. 386 - 388

12
[ 94522-81-3 ]
[ 523-50-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1933 - 1940
[2]Journal of Organic Chemistry,1957,vol. 22,p. 1696
[3]Journal of the Indian Chemical Society,1990,vol. 67,p. 71 - 72
[4]Tetrahedron,1992,vol. 48,p. 4239 - 4246

13
[ 116103-94-7 ]
[ 523-50-2 ]
[ 94522-81-3 ]

Reference： [1]Journal of Organic Chemistry,1957,vol. 22,p. 1696

14
[ 67-56-1 ]
[ 523-50-2 ]
[ 145039-58-3 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564

15
[ 523-50-2 ]
[ 6544-86-1 ]
[ 51559-40-1 ]
[ 145039-59-4 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564

16
[ 523-50-2 ]
[ 145039-59-4 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564

17
[ 523-50-2 ]
[ 80673-10-5 ]

Reference： [1]European Journal of Medicinal Chemistry,1981,vol. 16,p. 563 - 568

18
[ 523-50-2 ]
Furo[2,3-h]chromene-2-thione [ No CAS ]

Reference： [1]Farmaco, Edizione Scientifica,1985,vol. 40,p. 3 - 13

19
[ 233-28-3 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron Letters,1987,vol. 28,p. 1381 - 1384
[2]Journal of the American Chemical Society,1988,vol. 110,p. 7419 - 7434

20
[ 59292-71-6 ]
[ 1099-45-2 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,1995,vol. 51,p. 3087 - 3094

21
[ 184352-13-4 ]
[ 523-50-2 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 1986 - 1988

22
[ 197314-94-6 ]
[ 523-50-2 ]
9-Allyl-2H,8H-benzo[1,2-b;3,4-b']dipyran-2,8-dione [ No CAS ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1997,p. 2483 - 2493

25
[ 119658-44-5 ]
[ 86119-84-8 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,1958,vol. 4,p. 256,270

26
[ 56-23-5 ]
[ 93-35-6 ]
[ 2032-35-1 ]
7-hydroxy-coumarin sodium [ No CAS ]
[ 31005-02-4 ]
[ 523-50-2 ]

Reference： [1]Chemische Berichte,1934,vol. 67,p. 1214,1216

27
[ 7446-70-0 ]
[ 523-50-2 ]
[ 71-43-2 ]
[ 31231-46-6 ]

Reference： [1]Proceedings - Indian Academy of Sciences, Section A,1942,p. 151,154

28
[ 444109-48-2 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 2831 - 2837

29
[ 16851-02-8 ]
[ 66-97-7 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 4859 - 4863

30
8-(1-propenyl)-7-(vinyloxy)coumarin [ No CAS ]
[ 523-50-2 ]

Reference： [1]Journal of the Chinese Chemical Society,2004,vol. 51,p. 1019 - 1023

31
trans-8,9-dihydro-9-hydroxy-8-(1-hydroxy-1-methylethyl)-2H-furo[2,3-h]-1-benzopyran-2-one [ No CAS ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 1761 - 1770

32
[ 26992-52-9 ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,2005,vol. 70,p. 1761 - 1770

33
[ 55136-72-6 ]
[ 523-50-2 ]

Reference： [1]Journal of the Chinese Chemical Society,2004,vol. 51,p. 1019 - 1023
[2]Tetrahedron,2002,vol. 58,p. 2831 - 2837
[3]Tetrahedron,1958,vol. 4,p. 256,270

34
[ 849796-54-9 ]
[ 523-50-2 ]

Reference： [1]Journal of the Chinese Chemical Society,2004,vol. 51,p. 1019 - 1023

35
[ 93-35-6 ]
crotyl halide [ No CAS ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 2831 - 2837

36
[ 31005-03-5 ]
[ 523-50-2 ]

Reference： [1]Tetrahedron,2002,vol. 58,p. 2831 - 2837

37
[ 65763-00-0 ]
[ 523-50-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1933 - 1940
[2]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 1986 - 1988
[3]Tetrahedron,1992,vol. 48,p. 4239 - 4246

38
[ 93-35-6 ]
[ 523-50-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1933 - 1940
[2]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 1986 - 1988

39
[ 1221-46-1 ]
[ 523-50-2 ]

Reference： [1]Bioorganic and Medicinal Chemistry,1999,vol. 7,p. 1933 - 1940
[2]Tetrahedron,1992,vol. 48,p. 4239 - 4246

40
[ 2067-86-9 ]
[ 523-50-2 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1997,p. 2483 - 2493
[2]Journal of Organic Chemistry,1957,vol. 22,p. 1696
[3]Journal of Organic Chemistry,1957,vol. 22,p. 1696

41
[ 197314-93-5 ]
[ 523-50-2 ]

Reference： [1]Journal of the Chemical Society. Perkin transactions I,1997,p. 2483 - 2493

42
[ 184352-08-7 ]
[ 523-50-2 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 1986 - 1988

43
[ 112183-08-1 ]
[ 523-50-2 ]

Reference： [1]Journal of the American Chemical Society,1988,vol. 110,p. 7419 - 7434
[2]Tetrahedron Letters,1987,vol. 28,p. 1381 - 1384

44
[ 112183-09-2 ]
[ 523-50-2 ]

Reference： [1]Journal of the American Chemical Society,1988,vol. 110,p. 7419 - 7434
[2]Tetrahedron Letters,1987,vol. 28,p. 1381 - 1384

45
[ 112183-05-8 ]
[ 523-50-2 ]

Reference： [1]Journal of the American Chemical Society,1988,vol. 110,p. 7419 - 7434
[2]Tetrahedron Letters,1987,vol. 28,p. 1381 - 1384

46
[ 523-50-2 ]
5,6-furanohydrocoumaric acid methyl ester [ No CAS ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564
[2]Heterocycles,1992,vol. 34,p. 1555 - 1564

47
[ 523-50-2 ]
[ 145039-53-8 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564
[2]Heterocycles,1992,vol. 34,p. 1555 - 1564

48
[ 523-50-2 ]
[ 145039-57-2 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564
[2]Heterocycles,1992,vol. 34,p. 1555 - 1564
[3]Heterocycles,1992,vol. 34,p. 1555 - 1564
[4]Heterocycles,1992,vol. 34,p. 1555 - 1564

49
[ 523-50-2 ]
[ 145039-56-1 ]

Reference： [1]Heterocycles,1992,vol. 34,p. 1555 - 1564
[2]Heterocycles,1992,vol. 34,p. 1555 - 1564

50
3-Benzenesulfinyl-3,4-dihydro-2H-furo[2,3-h]chromene [ No CAS ]
[ 523-50-2 ]

Reference： [1]Tetrahedron Letters,1987,vol. 28,p. 1381 - 1384

51
[ 35722-50-0 ]
[ 523-50-2 ]

Reference： [1]Journal of the Indian Chemical Society,1990,vol. 67,p. 71 - 72

52
[ 6748-68-1 ]
[ 523-50-2 ]

Reference： [1]Journal of the Indian Chemical Society,1990,vol. 67,p. 71 - 72

53
[ 129110-46-9 ]
[ 523-50-2 ]

Reference： [1]Journal of the Indian Chemical Society,1990,vol. 67,p. 71 - 72

54
[ 523-50-2 ]
[ 6544-86-1 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966

55
[ 523-50-2 ]
3-(4-methoxy-benzofuran-5-yl)-propionic acid [ No CAS ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966
[2]Chemische Berichte,1936,vol. 69,p. 964,966

56
[ 523-50-2 ]
[ 1449-53-2 ]

Reference： [1]Chemische Berichte,1936,vol. 69,p. 964,966

57
[ 116103-94-7 ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,1957,vol. 22,p. 1696

58
[ 109185-78-6 ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,1957,vol. 22,p. 1696
[2]Journal of Organic Chemistry,1957,vol. 22,p. 1696

59
[ 480-97-7 ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 2978 - 2982

60
[ 1361944-38-8 ]
[ 523-50-2 ]

Reference： [1]Journal of Organic Chemistry,2012,vol. 77,p. 2978 - 2982

61
[ 523-50-2 ]
[ 2067-86-9 ]
C₁₂H₆O₇ [ No CAS ]

Reference： [1]RSC Advances,2014,vol. 4,p. 61277 - 61280

62
[ 523-50-2 ]
[ 2067-86-9 ]
C₁₀H₆O₄ [ No CAS ]

Reference： [1]RSC Advances,2014,vol. 4,p. 61277 - 61280

63
8-(prop-1-en-1-yl)-7-(prop-1-en-1-yloxy)-2H-chromen-2-one [ No CAS ]
[ 523-50-2 ]

Yield	Reaction Conditions	Operation in experiment
95%	With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In toluene; at 90℃; for 1.0h;Inert atmosphere;	General procedure: The appropriate precursors 9 or 10 (1.00 mmol) were dissolved in toluene (10 mL) andprecatalyst A (42 mg, 0.05 mmol, 5 mol %) was added. The mixture was heated to 90 C untilS10TLC indicated complete conversion (ca. 1 h), cooled to ambient temperature and evaporatedin vacuo. The residue was purified by column chromatography on silica using hexanes-MTBEmixtures of increasing polarity as eluents to furnish the products 3 or 11, respectively.

Reference： [1]Beilstein Journal of Organic Chemistry,2018,vol. 14,p. 2991 - 2998

64
[ 219489-13-1 ]
[ 2361306-76-3 ]
[ 523-50-2 ]

Yield	Reaction Conditions	Operation in experiment
47%	With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate In N,N-dimethyl-formamide at 80℃; for 16h; Schlenk technique; Sealed tube;

Reference： [1]Wienhold, Max; Molloy, John J.; Daniliuc, Constantin G.; Gilmour, Ryan [Angewandte Chemie - International Edition, 2021, vol. 60, # 2, p. 685 - 689][Angew. Chem., 2021, vol. 133, # 2, p. 695 - 699,5]

65
[ 523-50-2 ]
[ 353-83-3 ]
[ 2595088-94-9 ]

Yield	Reaction Conditions	Operation in experiment
34%	With tris[2-phenylpyridinato-C₂,N]iridium(III); potassium carbonate In dimethyl sulfoxide at 20℃; for 12h; Schlenk technique; Irradiation; Inert atmosphere;

Reference： [1]Chen, Xiaoyu; Li, Linlin; Pei, Congcong; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng [Journal of Organic Chemistry, 2021, vol. 86, # 3, p. 2772 - 2783]

66
[ 523-50-2 ]
[ 371-67-5 ]
[ 2687981-26-4 ]

Yield	Reaction Conditions	Operation in experiment
36%	With 1,8-diazabicyclo[5.4.0]undec-7-ene In 1,4-dioxane; tert-butyl methyl ether at 80℃; for 96h;

Reference： [1]Cao, Tingting; Lu, Shan; Sun, Yunfang; Wang, Lei; Yang, Zhen; Zhang, Jing; Zhao, Nannan [European Journal of Organic Chemistry, 2021, vol. 2021, # 21, p. 2950 - 2954]

67
[ 523-50-2 ]
[ 2091753-13-6 ]
[ CAS Unavailable ]

Yield	Reaction Conditions	Operation in experiment
54%	With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; sodium acetate In dimethyl sulfoxide at 45℃; for 24h; Inert atmosphere; Irradiation; regioselective reaction;

Reference： [1]Tao, Maoling; Wang, An-Jun; Guo, Peng; Li, Weipiao; Zhao, Liang; Tong, Jie; Wang, Haoyang; Yu, Yanbo; He, Chun-Yang [Advanced Synthesis and Catalysis, 2022, vol. 364, # 1, p. 24 - 29]

68
[ 523-50-2 ]
[ 35024-12-5 ]
[ 66645-40-7 ]

Yield	Reaction Conditions	Operation in experiment
55%	With Bromoeosine; potassium carbonate In dimethyl sulfoxide at 20℃; for 12h; Inert atmosphere; Irradiation; Schlenk technique;
55%	With potassium carbonate; Eosin In dimethyl sulfoxide at 25℃; for 12h; Irradiation;	22 Synthesis of Compound (I-22) Isopsoralen 0.1mmol, iodine ylide 0.15mmol,Eosin Y 0.002mmol, potassium carbonate 0.1mmol were added to the reaction tube,Soluble in dimethyl sulfoxide solvent, 25,The reaction was carried out under LED illumination for 12 hours, and the target product (I-22) was obtained by column chromatography, and the isolated yield was 55%.

Reference： [1]Cui, Xiuling; Pi, Chao; Ren, Jie; Wu, Yangjie [Green Chemistry, 2022, vol. 24, # 7, p. 3017 - 3022]
[2]Current Patent Assignee: ZHENGZHOU UNIVERSITY - CN113956208, 2022, A Location in patent: Paragraph 0157-0162

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P101	If medical advice is needed,have product container or label at hand.
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Code	Phrase
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P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
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P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
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Code	Phrase
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P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 523-50-2 ]

Quality Control of [ 523-50-2 ]

Related Doc. of [ 523-50-2 ]

Product Details of [ 523-50-2 ]

Calculated chemistry of [ 523-50-2 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 523-50-2 ]

Application In Synthesis of [ 523-50-2 ]

[ 523-50-2 ] Synthesis Path-Downstream 1~68

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry