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Chemical Structure| 527-73-1 Chemical Structure| 527-73-1

Structure of Azomycin
CAS No.: 527-73-1

Chemical Structure| 527-73-1

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Azomycin is a natural macrolide antimicrobial antibiotic against Gram-positive, Gram-negative bacteria and anaerobic bacteria, and also works as a hypoxia labeling agent.

Synonyms: 2-Nitroimidazole

4.5 *For Research Use Only !

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Abraha, Yuel W. ; Tsai, Chih-Wei ; Langner, Ernst H. G. ;

Abstract: Several ZIFs and their functionalised derivatives have been reported as efficient catalytic materials for the fixation of CO2 in the bid to reduce global warming, caused by the persistent use of fossil fuels. However, the major challenge of using these ZIFs at large scales requires the scalability of their synthesis. Herein, a series of Zn-based zeolite imidazolate frameworks (ML-ZIFs) with mixed linkers (2-methylimidazole and 2-nitroimidazole) were synthesized via an easily scalable procedure. The products were characterised by PXRD, TGA, TEM, N2 isotherms, digestive 1H NMR and evaluated as catalysts for CO2 fixation. All ML-ZIFs are thermally stable, highly porous with SOD or frl topologies and particle sizes of 44-360 nm. ML-ZIF 3 with [Zn(mIm)0.87(nIm)1.13] composition resulted in the highest CO2 uptake of 91 cm3g-1. ML-ZIF 4 (Zn(mIm)1.44(nIm)0.56) led to the highest catalytic activity (684 h-1) by a ZIF derivative in the cycloaddition of CO2 to epichlorohydrin substrate.

Keywords: Scalable ; ZIFs ; Catalysts ; CO2 fixation

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Abraha, Yuel W. ; Tsai, Chih-Wei ; Niemantsverdriet, J. W. Hans ; Langner, Ernst H. G. ;

Abstract: Zeolitic imidazolate frameworks, like ZIF-8 and related structures, have shown great potential for the capture of carbon dioxide. Modifying their structure by exchanging part of the constituent organic ligands is a proven method for enhancing the capacity to absorb CO2. In this work, we performed solvent-assisted ligand exchange (SALE) on nanosized ZIF-8 (nZIF-8) with a series of functionalized imidazole derivatives (exchange percentages, after 24 h): 2-bromoimidazole (19%), 2-chloroimidazole (29%), 2-trifluoromethylbenzimidazole (4%), 2-mercaptobenzimidazole (4%), and 2-nitroimidazole (54%). The sodalite topol. and porosity of nZIF-8 were maintained with all SALE modifications. Low-pressure CO2 adsorption of nZIF-8 (38.5 cm3 g-1) at STP was appreciably enhanced with all mixed-linker SALE products. Using halogenated (-Cl, -Br, and -CF3) imidazole derivatives in a 24 h SALE treatment resulted in increases between 11 and 22% in CO2 adsorption, while the thiol (-SH)- and nitro (-NO2)-functionalized SALE products led to 32 and 100% increases in CO2 uptakes, resp. These CO2 uptakes were further optimized by varying the SALE treatment time. The SHbIm- and NO2Im-exchanged SALE products of nZIF-8 show 87 and 98 cm3 g-1 of CO2 uptakes after 60 and 120 h of SALE, resp. These are record high CO2 adsorptions for all reported ZIF derivatives at low-pressure conditions.

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Alternative Products

Product Details of Azomycin

CAS No. :527-73-1
Formula : C3H3N3O2
M.W : 113.07
SMILES Code : O=[N+](C1=NC=CN1)[O-]
Synonyms :
2-Nitroimidazole
MDL No. :MFCD00005185
InChI Key :YZEUHQHUFTYLPH-UHFFFAOYSA-N
Pubchem ID :10701

Safety of Azomycin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H315-H319-H335
Precautionary Statements:P261-P301+P310-P305+P351+P338
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT01055678 Breast Cancer Early Phase 1 Withdrawn(PI left Duke) - United States, North Carolina ... More >> Duke University Medical Center Durham, North Carolina, United States, 27710 Less <<
NCT01995084 Pancreatic Cancer ... More >> Esophageal Cancer Rectal Cancer Less << Not Applicable Completed - Netherlands ... More >> Academic Medical Center Amsterdam, Netherlands, 1105AZ Less <<
NCT00430079 Adult Anaplastic Astrocytoma ... More >> Adult Anaplastic Ependymoma Adult Anaplastic Oligodendroglioma Adult Diffuse Astrocytoma Adult Ependymoma Adult Giant Cell Glioblastoma Adult Glioblastoma Adult Gliosarcoma Adult Mixed Glioma Adult Myxopapillary Ependymoma Adult Oligodendroglioma Adult Pilocytic Astrocytoma Adult Pineal Gland Astrocytoma Adult Subependymoma Less << Not Applicable Terminated(Administratively co... More >>mplete.) Less << - United States, Pennsylvania ... More >> Abramson Cancer Center of The University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00690053 Cancer Phase 1 Completed - Netherlands ... More >> Maastricht Radiation Oncology (MAASTRO clinic) Maastricht, Netherlands, 6229 ET Less <<
NCT00028782 Advanced Malignant Mesotheliom... More >>a Localized Malignant Mesothelioma Malignant Ascites Primary Peritoneal Cavity Cancer Recurrent Malignant Mesothelioma Less << Not Applicable Terminated(Administratively co... More >>mplete.) Less << - United States, Pennsylvania ... More >> Abramson Cancer Center of The University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Less <<
NCT00588276 Cervical Cancer ... More >> HEENT Cancer Renal Cancer Uterine Cancer CERVIX UTERI NOS RECTUM Less << Phase 1 Completed - United States, New York ... More >> Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 Less <<
NCT01248637 - Completed - Canada, Ontario ... More >> Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 Less <<
NCT01426074 Rectal Cancer Patients Phase 2 Withdrawn - -

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.84mL

1.77mL

0.88mL

44.22mL

8.84mL

4.42mL

88.44mL

17.69mL

8.84mL

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