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[ CAS No. 52927-22-7 ]

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Chemical Structure| 52927-22-7
Chemical Structure| 52927-22-7
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Product Details of [ 52927-22-7 ]

CAS No. :52927-22-7 MDL No. :MFCD01863480
Formula : C11H7NO Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W :169.18 g/mol Pubchem ID :4589476
Synonyms :

Safety of [ 52927-22-7 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 52927-22-7 ]

  • Upstream synthesis route of [ 52927-22-7 ]
  • Downstream synthetic route of [ 52927-22-7 ]

[ 52927-22-7 ] Synthesis Path-Upstream   1~5

  • 1
  • [ 52927-22-7 ]
  • [ 17579-79-2 ]
Reference: [1] Synlett, 2011, # 14, p. 2025 - 2028
  • 2
  • [ 78119-71-8 ]
  • [ 107-13-1 ]
  • [ 52927-22-7 ]
  • [ 130200-58-7 ]
Reference: [1] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 2, p. 303 - 306[2] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 2, p. 358 - 361
[3] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 2, p. 303 - 306[4] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 2, p. 358 - 361
  • 3
  • [ 78119-72-9 ]
  • [ 107-13-1 ]
  • [ 52927-22-7 ]
  • [ 130200-58-7 ]
Reference: [1] Journal of Organic Chemistry USSR (English Translation), 1981, vol. 17, # 2, p. 303 - 306[2] Zhurnal Organicheskoi Khimii, 1981, vol. 17, # 2, p. 358 - 361
  • 4
  • [ 52927-22-7 ]
  • [ 75-36-5 ]
  • [ 82957-06-0 ]
YieldReaction ConditionsOperation in experiment
53%
Stage #1: at 0 - 50℃; for 10 h;
Stage #2: With methanesulfonic acid In methanol; tert-butyl methyl ether
Take 800 ml of absolute ethanol in three bottles,The mixture was cooled to 0-5 ° C with stirring and 430 ml of acetyl chloride was added dropwise.Dropping completed, at 0 ~ 5 for a period of time, put 6-cyano-2-naphthol 85 g, 10 ° C for 10 hours, methyl tert-butyl ether was added and stirred for 1 hour to filter,The filter cake was washed with methyl tert-butyl ether, dried and mixed directly with ethanol, heated to 50 ,Dry ammonia was bubbled for 3 hours and evaporated to dryness under reduced pressure to give a yellow solid.The mixture was stirred with saturated sodium bicarbonate solution for a period of time, filtered, washed with water until neutral.Wet products suspended in methanol, dropping a certain amount of methanesulfonic acid solution,Methyl tert-butyl ether was added to precipitate a solid, which was filtered, washed with methyl tert-butyl ether,Recrystallization from ethanol gave 75 g of a yellow solid,The temperature of 227 ° C ~ 230 ° C,Yield 53percent.
Reference: [1] Patent: CN103896809, 2017, B, . Location in patent: Paragraph 0010; 0011; 0012; 0013
  • 5
  • [ 52927-22-7 ]
  • [ 82957-06-0 ]
Reference: [1] Chemical and Pharmaceutical Bulletin, 1985, vol. 33, # 4, p. 1458 - 1471
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