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[ CAS No. 53078-70-9 ]

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Chemical Structure| 53078-70-9
Chemical Structure| 53078-70-9
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Product Details of [ 53078-70-9 ]

CAS No. :53078-70-9 MDL No. :MFCD03425693
Formula : C9H9NO Boiling Point : 277.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :-
M.W :147.17 g/mol Pubchem ID :3801023
Synonyms :

Safety of [ 53078-70-9 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P280 UN#:N/A
Hazard Statements:H317 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 53078-70-9 ]

  • Downstream synthetic route of [ 53078-70-9 ]

[ 53078-70-9 ] Synthesis Path-Downstream   1~13

  • 1
  • [ 53078-70-9 ]
  • [ 25045-36-7 ]
  • 2
  • [ 104-93-8 ]
  • [ 545-06-2 ]
  • [ 53078-70-9 ]
  • 3
  • [ 120-71-8 ]
  • [ 53078-70-9 ]
  • 4
  • [ 22002-45-5 ]
  • [ 544-92-3 ]
  • [ 53078-70-9 ]
  • 5
  • [ 53078-70-9 ]
  • [ 51282-90-7 ]
YieldReaction ConditionsOperation in experiment
To a solution of 2-methoxy 5-methyl benzonitrile, 6 (3.00g, 20.0 mmol) in DCM (7 mL), boron tribromide (15.32 g, 5.78 niL, 60.0 mmol) is added slowly at 0 0C. The reaction is stirred at room temperature for 2Oh and is quenched by slow addition of water (10 mL), layers are separated. The organic layer is washed with saturated aq. NaCl solution (50 mL X2), dried on anhydrous Na2SO4 and evaporated under reduced pressure to get compound 7 as solid product. (2.50 g)
  • 6
  • [ 151-50-8 ]
  • [ 120-71-8 ]
  • [ 53078-70-9 ]
  • 7
  • [ 7647-01-0 ]
  • [ 7446-70-0 ]
  • [ 104-93-8 ]
  • [ 545-06-2 ]
  • [ 53078-70-9 ]
  • 10
  • [ 104-93-8 ]
  • [ 4885-02-3 ]
  • [ 53078-70-9 ]
  • 11
  • [ 53078-70-9 ]
  • 2-(4-((1H-pyrazol-1-yl)methyl)benzyl)-N-(2-methoxy-5-methylbenzyl)-2H-pyrazolo[3,4-d]pyrimidin-4-amine [ No CAS ]
  • 12
  • [ 53078-70-9 ]
  • [ 7383-12-2 ]
YieldReaction ConditionsOperation in experiment
10% In tetrahydrofuran; at 0℃; for 1.25h;Inert atmosphere; Reflux; (2-methoxy-5-methylphenyl)methanamineInto a 250-mL 3-necked round-bottom flask purged and maintained with an inert atmosphere of nitrogen, was placed a solution of <strong>[53078-70-9]2-methoxy-5-methylbenzonitrile</strong> (1 g, 6.79 mmol, 1.00 equiv) in tetrahydrofuran (100 mL) with stirring at 0 C., to which was added 2M BH3-Me2S in tetrahydrofuran solution (12 mL, 4.00 equiv) dropwise with stirring at 0 C. in 10 min. The resulting mixture was stirred for 5 min at 0 C. and refluxed for 1 h. The reaction was then quenched by the addition of 7 mL of methanol. The reaction mixture was concentrated under vacuum. The crude product was purified by Combi-Flash with the following conditions. Column: C 18, 20-45 um, 100 A, 120 g; mobile phase: water (it contains 0.05% ammonia and 10 mM NH4HCO3) and acetonitrile with a gradient of 30% to 65% acetonitrile in 12 min; flow rate: 60 mL/min; detector UV wavelength: 254 nm and 220 nm. This resulted in 100 mg (10%) of (2-methoxy-5-methylphenyl)methanamine as white solid. MS (ESI) m/z found for C9H13NO: 152 [M+H]+.
  • 13
  • [ 124-38-9 ]
  • [ 53078-70-9 ]
  • (3-cyano-4-methoxy-phenyl)-acetic acid [ No CAS ]
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