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[ CAS No. 53234-55-2 ]

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Chemical Structure| 53234-55-2
Chemical Structure| 53234-55-2
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CAS No. :53234-55-2 MDL No. :MFCD09152775
Formula : C7H4N2O2 Boiling Point : 370.7°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :148.12 g/mol Pubchem ID :12400734
Synonyms :

Safety of [ 53234-55-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P280-P305+P351+P338 UN#:N/A
Hazard Statements:H317-H319 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 53234-55-2 ]

  • Upstream synthesis route of [ 53234-55-2 ]
  • Downstream synthetic route of [ 53234-55-2 ]

[ 53234-55-2 ] Synthesis Path-Upstream   1~7

  • 1
  • [ 76196-66-2 ]
  • [ 53234-55-2 ]
Reference: [1] Patent: US2009/209755, 2009, A1, . Location in patent: Page/Page column 51-52
[2] Patent: WO2010/13794, 2010, A1, . Location in patent: Page/Page column 87
[3] Patent: US2010/93999, 2010, A1, . Location in patent: Page/Page column 35
[4] Patent: WO2011/9897, 2011, A1, . Location in patent: Page/Page column 74
[5] Patent: WO2011/9898, 2011, A1, . Location in patent: Page/Page column 83
[6] Patent: US2012/190672, 2012, A1, . Location in patent: Page/Page column 33
[7] Patent: WO2012/98213, 2012, A1, . Location in patent: Page/Page column 66
  • 2
  • [ 33252-28-7 ]
  • [ 201230-82-2 ]
  • [ 53234-55-2 ]
YieldReaction ConditionsOperation in experiment
98.95 g With dichloro [1,1'-bis(diphenylphosphino)propane]palladium(II); triethylamine In water; <i>tert</i>-butyl alcohol at 60℃; for 10 h; Autoclave; Inert atmosphere Example 15-Cyano-pyridine-2-carboxylic acid A 2 L stirred autoclave was charged under argon with PdC12(dppp) (2.13 g, 3.61 mmol), 6- chloro-nicotinonitrile (100 g, 0.722 mol), tert-butanol (800 ml), deionized water (200 ml) andtriethylamine (250 ml, 1.8 mol). The reaction vessel was closed, purged three times with carbonmonoxide (10 bar) and finally charged with carbon monoxide to 15 bar. The mixture was stirredvigorously at 60°C under constant pressure for 10 h; after this time no more carbon monoxideabsorption was observed. The reaction mixture was concentrated on a rotary evaporator such thatthe volatile organic components were removed. The resulting aqueous phase was filtered,extracted with dichloromethane and treated with active charcoal. After filtration, the pH of thesolution was reduced under stuffing at 60°C to ca. 0.7 by dropwise addition of hydrochloric acid.The resulting suspension was stirred at room temperature over night and then filtered. The filter cake was rinsed with water and dried in vacuo to constant weight to afford 5-cyano-pyridine-2- carboxylic acid (98.95 g) as a white solid, MS: mlz = 104 [M-C021, m.p.: 207 °C (dcc).
Reference: [1] Patent: WO2014/173917, 2014, A1, . Location in patent: Page/Page column 13; 14
  • 3
  • [ 33252-28-7 ]
  • [ 201230-82-2 ]
  • [ 100-54-9 ]
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Reference: [1] Patent: WO2014/173917, 2014, A1, . Location in patent: Page/Page column 15; 16
  • 4
  • [ 3222-48-8 ]
  • [ 7757-82-6 ]
  • [ 53234-55-2 ]
Reference: [1] Patent: US2003/64978, 2003, A1,
  • 5
  • [ 24242-18-0 ]
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Reference: [1] Patent: US6265418, 2001, B1,
  • 6
  • [ 65346-04-5 ]
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Reference: [1] Chemische Berichte, 1984, vol. 117, # 3, p. 1259 - 1261
  • 7
  • [ 29682-15-3 ]
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Reference: [1] Patent: WO2011/9897, 2011, A1,
[2] Patent: WO2011/9898, 2011, A1,
[3] Patent: US2012/190672, 2012, A1,
[4] Patent: WO2012/98213, 2012, A1,
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