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[ CAS No. 53312-78-0 ] {[proInfo.proName]}

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2D 3D

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Chemical Structure| 53312-78-0

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Quality Control of [ 53312-78-0 ]

COA NMR CNMR HPLC LC-MS

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Alternatived Products of [ 53312-78-0 ]

Product Details of [ 53312-78-0 ]

CAS No. :	53312-78-0	MDL No. :	MFCD06797224
Formula :	C₇H₅ClN₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	JRBVDAQXMNYPHC-UHFFFAOYSA-N
M.W :	152.58	Pubchem ID :	11030024
Synonyms :

Safety of [ 53312-78-0 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 53312-78-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 53312-78-0 ]
Downstream synthetic route of [ 53312-78-0 ]

[ 53312-78-0 ] Synthesis Path-Upstream 1~1

1
[ 34662-30-1 ]
[ 53312-78-0 ]

Yield	Reaction Conditions	Operation in experiment
40%	With tin(ll) chloride In N,N-dimethyl-formamide at 20℃;	3-Chloro-5-nitrobenzonitrile was reduced to 3-amino-5-chlorobenzonitrile by treating with 6 equivalents of SnCl₂dihydrate in DMF at RT overnight. The product was purified by chromatography over silica gel (40percent yield). LCMS (Cond. A) RT 1.61 min., MH⁺153. ¹H NMR (500 MHz, CDCl₃) δ 6.97 (s, 1H), 6.84 (t, J=2.0 Hz, 1H), 6.77 (s, 1H).

Reference： [1] Patent: US2006/287287, 2006, A1, . Location in patent: Page/Page column 17-18

[ 53312-78-0 ] Synthesis Path-Downstream 1~29

1
[ 13947-76-7 ]
[ 53312-78-0 ]
[ 150596-95-5 ]

Reference： [1]Journal of Organic Chemistry,1993,vol. 58,p. 5118 - 5120
[2]Journal of Organic Chemistry,1993,vol. 58,p. 5118 - 5120

2
[ 463-71-8 ]
[ 53312-78-0 ]
[ 185500-56-5 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050
[2]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

3
[ 53312-78-0 ]
4-methyl-N'-[(1E)-pyridin-2-ylmethylene]benzenesulfonohydrazide [ No CAS ]
3-chloro-5-(5-pyridin-2-yl-tetrazol-2-yl)-benzonitrile [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5061 - 5064

4
[ 53312-78-0 ]
(3-Chloro-5-cyano-phenyl)-(1,1,2-trimethyl-propyl)-carbodiimide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

5
[ 53312-78-0 ]
(3-Chloro-5-cyano-phenyl)-(1-ethyl-1-methyl-propyl)-carbodiimide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

6
[ 53312-78-0 ]
1-(3-Chloro-5-cyano-phenyl)-3-(1-ethyl-1-methyl-propyl)-thiourea [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

7
[ 53312-78-0 ]
1-(3-Chloro-5-cyano-phenyl)-3-(1,1,2-trimethyl-propyl)-thiourea [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

8
[ 53312-78-0 ]
(3-Chloro-5-cyano-phenyl)-(1,1-diethyl-propyl)-carbodiimide [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

9
[ 53312-78-0 ]
1-(3-Chloro-5-cyano-phenyl)-3-(1,1-diethyl-propyl)-thiourea [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

10
[ 53312-78-0 ]
C₁₅H₁₈ClN₅ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

11
[ 53312-78-0 ]
C₁₅H₁₈ClN₅ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

12
[ 53312-78-0 ]
C₁₆H₂₀ClN₅ [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,1998,vol. 8,p. 3397 - 3402

13
[ 53312-78-0 ]
[ 150596-95-5 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

14
[ 53312-78-0 ]
N-(3-Chloro-5-cyanophenyl)-N'-cyano-N''-tert-pentylguanidine [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

15
[ 53312-78-0 ]
[ 1026006-49-4 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

16
[ 53312-78-0 ]
[ 185500-53-2 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

17
[ 53312-78-0 ]
[ 144930-87-0 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

18
[ 53312-78-0 ]
C₁₃H₁₄ClN₅ [ No CAS ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1996,vol. 44,p. 2042 - 2050

19
[ 53312-78-0 ]
3-amino-5-chlorobenzylamine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dimethylsulfide borane complex; In tetrahydrofuran; at 20℃; for 3h;Heating / reflux;	To the solution of <strong>[53312-78-0]3-amino-5-chlorobenzonitrile</strong> in THF at RT was added slowly borane methyl sulfide complex (2.5 eq.). The resulting reaction mixture was stirred at RT for 1 h and heated at reflux for 2 hrs. The reaction mixture was cooled to -30 C. and MeOH was added slowly to quench the reaction. Solvent was evaporated in vacuo after the reaction mixture was stirred at RT for 30 min. to give 3-amino-5-chlorobenzylamine, which was used without purification. LCMS (Method A) RT 0.16 min., MH+ 157.

Reference： [1]Patent: US2006/287287,2006,A1 .Location in patent: Page/Page column 17-18

20
[ 34662-30-1 ]
[ 53312-78-0 ]

Yield	Reaction Conditions	Operation in experiment
40%	With tin(ll) chloride; In N,N-dimethyl-formamide; at 20℃;	3-Chloro-5-nitrobenzonitrile was reduced to 3-amino-5-chlorobenzonitrile by treating with 6 equivalents of SnCl2 dihydrate in DMF at RT overnight. The product was purified by chromatography over silica gel (40% yield). LCMS (Cond. A) RT 1.61 min., MH+ 153. 1H NMR (500 MHz, CDCl3) delta 6.97 (s, 1H), 6.84 (t, J=2.0 Hz, 1H), 6.77 (s, 1H).

Reference： [1]Patent: US2006/287287,2006,A1 .Location in patent: Page/Page column 17-18

21
[ 75-64-9 ]
[ 53312-78-0 ]
[ 1203655-74-6 ]

Yield	Reaction Conditions	Operation in experiment
52%		To a suspension of <strong>[53312-78-0]5-cyano-3-chloroaniline</strong> (3.44 g) in concentrated HCI (84 ml) was added dropwise a solution of NaNO2 (1.72 g) in H2O (6 ml) at -5 0C. The reaction mixture was vigorously stirred at -5 0C for 1.5 h. To a solution of CuCi2 (0.18 g) in H2O (2 ml) and acetic acid (150 m), SO2 was bubbled at -5 0C for 20 min. The suspension of the prepared diazonium salt was added dropwise at -10 0C and stirred at room temperature for 3 h. The reaction mixture was poured into H2O/ ice (500 ml) and extracted with ether (2 x 300 ml). The organic layer was washed with H2O (3 x 200 ml), dried over Na2SO4 and concentrated. The crude sufonylchloride was dissolved in THF (100 ml) and cooled to 0 0C. Pyridine (6.2 ml) was added foliowed by NBuNH2 (2.86 g). The resulting mixture was warmed to room temperature and stirred for 2 h. The reaction mixture was diluted with EtOAc (300 ml) and washed with brine (2 * 100 ml), 1 N HCl (2 x 100 ml) and brine (100 ml). The organic layer was dried over Na2SO4, concentrated and purified by silica gel column chromatography to give N-f-butyl-3-chioro-5-cyano-benzenesulfonamide (3.18 g, 52% yield) as a white solid.

Reference： [1]Patent: WO2010/2998,2010,A1 .Location in patent: Page/Page column 98-99

22
[ 1220631-64-0 ]
[ 53312-78-0 ]
[ 1220628-11-4 ]

Yield	Reaction Conditions	Operation in experiment
12.61%		Example 14: Preparation of 8-amino-6-((3-chloro-5- cyanophenyl)amino)imidazo[ 1 ,2-b]pyridazine-3-carbonitrile[00276] A mixture of 14A (100 mg, 0.23 mmol), cesium carbonate (225 mg, 0.69 mmol), copper(I) iodide (21.95 mg, 0.12 mmol), <strong>[53312-78-0]3-amino-5-chlorobenzonitrile</strong> (38.7 mg, 0.25 mmol), Pd2(dba)3 (21.10 mg, 0.023 mmol) and Xantphos (29.3 mg, 0.051 mmol) in DMA (2 mL) was purged with nitrogen and heated at 125 0C. After 13 hours, the reaction mixture was diluted with DCM, filtered through a silica gel plug (2Og) and washed with 10% MeOH in DCM. The filtrate was concentrated, triturated with water, and the solid was collected via filtration. The solid was dried under reduced pressure, dissolved in DCM (2 mL), and treated with triethylsilane (0.64 mL) and TFA (1.3 mL). After 1 hour, the reaction mixture was concentrated, re-dissolved in MeOH/DMSO and purified by HPLC (PHENOMENEX Luna Axia 5 micron 30 x 100mm) 30% B (Solvent B = 90% MeOH - 10% H2O - 0.1% TFA) to 100% B in A (Solvent A = 10% MeOH - 90% H2O - 0.1% TFA) in 15 min.) to isolate Example 14 (9 mg, 0.029 mmol, 12.61 % yield) as a light brown solid. HPLC: Rt = 0.88 min. (PHENOMENEX Luna 5 micron Cl 8 4.6 x 30 mm, 10-90% aqueous methanol containing 0.1% TFA; 2 min. gradient, flow rate = 5 mL/min., detection at 254 nm). MS (ES): m/z = 310.0 [M+H]+. 1H NMR (400 MHz, DMSO-d6) delta ppm 9.71 (1 H, s), 8.19 (1 H, s), 8.14 (1 H, t, J = 2.01 Hz), 7.97 - 8.07 (1 H, m), 7.46 - 7.57 (1 H, m), 7.28 (2 H, br. s.), 6.04 (1 H, s).

Reference： [1]Patent: WO2010/42699,2010,A1 .Location in patent: Page/Page column 144

23
[ 40137-29-9 ]
[ 64195-85-3 ]
[ 53312-78-0 ]
[ 1441737-09-2 ]

Yield	Reaction Conditions	Operation in experiment
1.8 g	With acetic acid; at 120℃; for 16h;	A mixture of <strong>[53312-78-0]3-amino-5-chloro-benzonitrile</strong> (2.4 g, 15.7 mmol), 4-chloro-2-methyl- benzaldehyde (2.4 g, 15.7 mmol) and 5-methyl-2,4-dioxo-hexanoic acid ethyl ester (2.9 g, 15.7 mmol) in acetic acid (15 mL) was stirred at 120C for 16 h. The reaction mixture was allowed to cool to rt, concentrated, diluted with acetonitrile (15 mL), and stirred for 4 h at rt The resulting precipitate was collected by vacuum filtration and dried to afford 1.8 g of the title compound. tR: 6.50 min (HPLC 2); ESI-MS: 429 [M+H]+(LC-MS 2); Rf= 0.27(hexane/EtOAc, 1 :1 ).

Reference： [1]Patent: WO2013/80141,2013,A1 .Location in patent: Page/Page column 98

24
(3R*,4R*)-2-isobutyl-1-oxo-3-(thiophen-2-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxylic acid [ No CAS ]
[ 53312-78-0 ]
C₂₅H₂₂ClN₃O₂S [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2016,vol. 59,p. 7950 - 7962

25
[ 5600-21-5 ]
[ 53312-78-0 ]
3-((2-amino-6-methylpyrimidin-4-yl)amino)-5-chlorobenzonitrile [ No CAS ]

Reference： [1]Journal of Medicinal Chemistry,2018,vol. 61,p. 1182 - 1203

26
[ 53312-78-0 ]
tert-butyl (3-((3-(aminomethyl)-5-chlorophenyl)amino)-3-oxopropyl)carbamate [ No CAS ]

Reference： [1]Patent: WO2020/37155,2020,A1

27
[ 53312-78-0 ]
tert-butyl (3-((3-chloro-5-((6-chloro-2,3,4,9-tetrahydro-1Hpyrido[3,4-b] indole-2-carboxamido) methyl)phenyl)amino)-3-oxopropyl)carbamate [ No CAS ]

Reference： [1]Patent: WO2020/37155,2020,A1

28
[ 53312-78-0 ]
N-(3-(3-aminopropanamido)-5-chlorobenzyl)-6-chloro-1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indole-2-carboxamide [ No CAS ]

Reference： [1]Patent: WO2020/37155,2020,A1

29
[ 3303-84-2 ]
[ 53312-78-0 ]
tert-butyl (3-((3-chloro-5-cyanophenyl)amino)-3-oxopropyl)carbamate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
70.8%	With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 25℃; for 1h;	Representative of synthesis of ( N-(3-(3-aminopropanamido)-5-chlorobenzyl)-6 - chloro-1, 3, 4,9-tetrahydro-2H-pyrido[ 3, 4-b lindole-2-carboxamide : To a solution of 3-amino-5- chlorobenzonitrile (1.0 g, 6.55 mmol,1.0 eq), 3-((tert-butoxycarbonyl) amino) propanoic acid (1.24 g, 6.55 mmol,1.0 eq) and HATU (2.98 g, 7.86 mmol,1.2 eq) in DMF (15 mL) was added DIEA (2.5 g,19.65 mmol, 3.0 eq) at 25 C. Then the reaction mixture was stirred at 25 C for 1 hr. TLC showed 3 -amino-5 -chlorobenzonitrile was consumed completely and one new spot formed. The reaction mixture was diluted with water (100 mL) and extracted with ethyl acetate (100 mL x 3). The combined organic phase was concentrated in vacuo. The residue was purified by silica gel column chromatography (eluent: PE/EA = 5/1 to 3/1) to give tert-butyl (3 -((3- chloro-5-cyanophenyl) amino)-3-oxopropyl) carbamate (1.5 g, yield: 70.8%) as a yellow solid. NMR (400 MHz, DMSO-^) d 10.42 (s,1 H), 7.98 (d, J = 1.6 Hz,1 H), 7.92 (s,1H), 7.71 -7.67 (m,1 H), 6.90 (t, J = 5.2 Hz,1 H), 3.32 (s, 2 H), 3.22 (dd, J = 12.8, 6.8 Hz, 2 H),1.37 (s, 9 H). [0234] To a solution of tert-butyl (3-((3-chloro-5-cyanophenyl) amino)-3-oxopropyl) carbamate (500 mg,1.54 mmol,1.0 eq) in methanol (10.0 mL) was added Raney-Ni (180 mg, 3.08 mmol, 2.0 eq) and NH3·H20 (0.1 mL). The reaction was stirred at 25 C for 4 hrs under . LCMS showed the complete consumption of the starting material, and the desired product mass was detected. The reaction mixture was filtered and concentrated in vacuo to give tert-butyl (3- ((3-(aminomethyl)-5-chlorophenyl) amino)-3-oxopropyl) carbamate (460 mg, yield: 90.9%) as a yellow oil. LCMS: [M+H] + = 328.1

Reference： [1]Patent: WO2020/37155,2020,A1 .Location in patent: Paragraph 0232-0233

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Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
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P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
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P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
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P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
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P263	Avoid contact during pregnancy/while nursing.
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P270	Do not eat, drink or smoke when using this product.
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P281	Use personal protective equipment as required.
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P285	In case of inadequate ventilation wear respiratory protection.
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Response
Code	Phrase
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P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
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P337	If eye irritation persists:
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P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
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P378
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P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
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P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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P413
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P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
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P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere