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[ CAS No. 53312-79-1 ]

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Chemical Structure| 53312-79-1

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Product Details of [ 53312-79-1 ]

CAS No. :	53312-79-1	MDL No. :	MFCD00017089
Formula :	C₇H₅ClN₂	Boiling Point :	292°C at 760 mmHg
Linear Structure Formula :	-	InChI Key :	-
M.W :	152.58 g/mol	Pubchem ID :	104464
Synonyms :

Safety of [ 53312-79-1 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H317-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 53312-79-1 ]

Upstream synthesis route of [ 53312-79-1 ]
Downstream synthetic route of [ 53312-79-1 ]

[ 53312-79-1 ] Synthesis Path-Upstream 1~7

1
[ 939-80-0 ]
[ 53312-79-1 ]

Yield	Reaction Conditions	Operation in experiment
97%	With sodium hydrogen sulfide In tetrahydrofuran; water at 45℃;	Example 1; Preparation of N-(1-(5-cyano-2-(3,5-dichlorophenoxy)phenylsulfonyl)piperidin-4-yl)-3-fluorobenzenesulfonamide (25) Commercially available 4-chloro-3-benzonitrile was dissolved in 4 parts THF. One part water was added with sodium hydrosulfide (3 eq.) and stirred overnight at 45° C. TLC (25percent EtOAc in hexanes) confirmed completion of the reaction. THF was evaporated in vacuo and the product precipitated. The white solid was collected via vacuum filtration, washed with water and dried in a vacuum oven with gentle heating (97.0percent yield).

Reference： [1] Patent: US2011/230487, 2011, A1, . Location in patent: Page/Page column 35
[2] Synlett, 2010, # 20, p. 3019 - 3022
[3] Patent: US2012/196824, 2012, A1,
[4] Recueil des Travaux Chimiques des Pays-Bas, 1947, vol. 66, p. 369[5] Chem.Abstr., 1948, vol. 42, p. 148
[6] Patent: US2003/139390, 2003, A1,
[7] Chemical Communications, 2015, vol. 51, # 61, p. 12197 - 12200
[8] Chemical Communications, 2015, vol. 51, # 66, p. 13086 - 13089
[9] RSC Advances, 2016, vol. 6, # 27, p. 23038 - 23047
[10] ACS Catalysis, 2016, vol. 6, # 11, p. 7844 - 7854

2
[ 939-80-0 ]
[ 7732-18-5 ]
[ 53312-79-1 ]

Reference： [1] Patent: US5744643, 1998, A,
[2] Patent: US5744643, 1998, A,

3
[ 939-80-0 ]
[ 53312-79-1 ]

Reference： [1] Tetrahedron Letters, 1995, vol. 36, # 51, p. 9305 - 9308

4
[ 939-80-0 ]
[ 53312-79-1 ]

Reference： [1] Patent: US4091011, 1978, A,

5
[ 623-03-0 ]
[ 53312-79-1 ]

Reference： [1] RSC Advances, 2016, vol. 6, # 27, p. 23038 - 23047

6
[ 53312-79-1 ]
[ 942199-56-6 ]

Reference： [1] RSC Advances, 2016, vol. 6, # 27, p. 23038 - 23047

7
[ 53312-79-1 ]
[ 385432-46-2 ]

Reference： [1] Patent: WO2017/69980, 2017, A1,
[2] Patent: WO2017/117393, 2017, A1,

[ 53312-79-1 ] Synthesis Path-Downstream 1~26

1
[ 53312-79-1 ]
3-amino-2,6-dibromo-4-chloro-benzonitrile [ No CAS ]

Reference： [1]Recueil des Travaux Chimiques des Pays-Bas,1947,vol. 66,p. 369
Chem.Abstr.,1948,vol. 42,p. 148

2
[ 53312-79-1 ]
[ 108-95-2 ]
[ 16604-97-0 ]

Reference： [1]Journal of Organic Chemistry USSR (English Translation),1967,vol. 3,p. 1795 - 1799
Zhurnal Organicheskoi Khimii,1967,vol. 3,p. 1839 - 1843

3
[ 53312-79-1 ]
4-methyl-N'-[(1E)-pyridin-2-ylmethylene]benzenesulfonohydrazide [ No CAS ]
4-chloro-3-(5-pyridin-2-yl-tetrazol-2-yl)-benzonitrile [ No CAS ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 5061 - 5064

4
[ 53312-79-1 ]
N-allyl-3-cyanoacetanilide [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1998,vol. 52,p. 549 - 554

5
[ 53312-79-1 ]
1-acetyl-6-cyano-3-methyl-2,3-dihydroindole [ No CAS ]

Reference： [1]Acta Chemica Scandinavica,1998,vol. 52,p. 549 - 554

6
[ 53312-79-1 ]
[ 207992-39-0 ]

Reference： [1]Acta Chemica Scandinavica,1998,vol. 52,p. 549 - 554

7
[ 53312-79-1 ]
[ 149367-90-8 ]

Yield	Reaction Conditions	Operation in experiment
	In N,N-dimethyl-formamide;	Example 243 2-Mercapto-benzothiazole-5-carbonitrile (243) The title compound was prepared using the method of Example 239, starting with <strong>[53312-79-1]3-amino-4-chloro-benzonitrile</strong> (242) (9.0 g, 59.0 mmol), O-ethylxanthic acid, potassium salt (Lancaster, 21.23 g, 132.7 mmol) in DMF (90 mL). 5.6 g (49%) of compound 243 was obtained as a pale brown solid. 1H NMR (DMSO-d6) delta 14.10 (br s, 1H), 7.90 (d, J=8.3 Hz, 1H), 7.70 (dd, J=8.3, 1.1 Hz, 1H), 7.60 (br s, 1H). MS (M-H) 191.

Reference： [1]Patent: US2003/139390,2003,A1

Yield	Reaction Conditions	Operation in experiment
		List of diazo components ... 19. 2-methylsulfonyl-4-chloroaniline 20. methyl-2-aminobenzoate 21. dimethyl-2-aminoterephthalate 22. 3-amino-4-methylbenzonitrile 23. 3-amino-4-chlorobenzonitrile 24. 3-chloro-1-aminoanthraquinone 25. 2-aminoanthraquinone

9
[ 53312-79-1 ]
[ 67-64-1 ]
4-Chloro-3-(isopropylamino)benzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		4-Chloro-3-(isoropylamino)benzonitrile To <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (470 mg, 3.09 mmol) and acetone (1.2 mL, 16.1 mmol) in ClCH2CH2Cl (10 mL) was added NaB(OAc)3H (2.62 g, 12.3 mmol). The reaction mixture was stirred at room temperature for 18 h. The reaction mixture was diluted with saturated aqueous solution of NaHCO3, extracted with CH2Cl2, washed with brine, dried and concentrated. Flash chromatography of the residue, using 1:9 MeOH-CH2Cl2, gave the amine 4-chloro-3-(isopropylamino)benzonitrile (0.35 g). 1H NMR (CDCl3) delta 7.33 (d, J=9.0 Hz, 1 H), 6.90 (d, J=9.0 Hz, 1 H), 6.88(s, 1H), 4.35(br, 1 H), 3.67(m, 1 H), 1.31 (br, 6 H).

Reference： [1]Patent: US2006/293392,2006,A1 .Location in patent: Page/Page column 48

10
[ 75-34-3 ]
[ 13865-19-5 ]
[ 53312-79-1 ]
[ 721450-86-8 ]

Yield	Reaction Conditions	Operation in experiment
2.21 g (>100%)	With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; In acetic acid;	(b) 4-(2-Chloro-5-cyano-phenylamino)-butyric acid methyl ester. To a stirring solution of <strong>[53312-79-1]3-amino-4-chloro-benzonitrile</strong> (1.19 g, 7.83 mmol), glacial acetic acid (1.8 mL, 31 mmol), 4-oxo-butyric acid methyl ester (4.00 g, 31 mmol) and dichloroethane (150 mL) was added sodium triacetoxyborohydride (6.74 g, 31.8 mmol) and the reaction mixture was stirred at room temperature for 15 h. The solvent was removed by rotary evaporation and the residue was diluted with EtOAc (100 mL) and water (50 mL). Saturated NaHCO3 was added until the aqueous layer was neutralized and then the organic layer was collected, dried over Na2SO4, and the solvent was removed by rotary evaporation. The residue was purified by flash column chromatography (silica gel, elution with EtOAc:hexanes, 1:3.5), to give 2.21 g (>100%) of the title compound as a mixture. 1H NMR (CDCl3): 7.32 (d, 1H, J=8.0 Hz), 6.90 (dd, 1H, J=8.0 and 1.9 Hz), 4.64 (br s, 1H), 3.71 (s, 3H), 3.25 (q, 2H, J=7.0 Hz), 2.47 (t, 2H, J=7.0 Hz), 2.04 (q, 2H, J=7.0 Hz).

Reference： [1]Patent: US2004/127521,2004,A1

11
[ 53312-79-1 ]
[ 140-89-6 ]
[ 149367-90-8 ]

Yield	Reaction Conditions	Operation in experiment
99%	In 1-methyl-pyrrolidin-2-one; at 140℃; for 2h;	Step A:2-Th ioxo-2 , 3-d ihyd robenzoth iazole-5-carbon itrile; A mixture of <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (200 mg, 1.32 mmol) and potassium o-ethyl- xanthate (422 mg, 2.64 mmol) in lambda/-methyl-2-pyrrolidone (1.5 ml.) was heated at 140 0C for 2 h. After cooling, the mixture was poured into ice-water. Then concentrated hydrochloric acid(0.2 ml.) was added. The solid was collected, washed with water and dried to give 2-thioxo-2,3-dihydrobenzothiazole-5-carbonitrile 250 mg (99 %).1H NMR (400 MHz, CDCI3): delta 7.53-7.50 (m, 2 H); 7.49 (s, 1 H).
	In 1-methyl-pyrrolidin-2-one; at 25 - 120℃; for 10h;Inert atmosphere;	j00316j A mixture of <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (1.0 g, 6.6 mmol) and potassium 0-ethyl carbonodithioate (2.1 g, 13.1 mmol) in 1-methylpyrrolidin-2-one (5 mL) at 25 C was degassed and purged with nitrogen 3 times. The mixture was stirred at 120 C for 10 hours, then poured into ice water (200 mL) and acidified with 1 mL concentrated hydrochloric acid, resulting in formation of a solid. The solid was collected by filtration, washed with water (3 x 10 mL) and dried in vacuo to give compound B-22 (1.1 g, crude) as a yellow solid, which was used directly without further purification. LCMS (B): tR=0.613 mi, (ES) mz (M+H) = 193.1.

Reference： [1]Patent: WO2007/110364,2007,A1 .Location in patent: Page/Page column 55
[2]Patent: WO2017/69980,2017,A1 .Location in patent: Paragraph 00315; 00316

12
[ 4220-66-0 ]
[ 53312-79-1 ]
[ 721450-86-8 ]

Yield	Reaction Conditions	Operation in experiment
		4-Chloro-3-(N-methyl-N-(4-butyric acid methyl ester)-amino)-benzonitrile A solution of 4,4-Dimethoxy-butyric acid methyl ester (5.0 g, 30.8 mmol), 1.2 M hydrochloric acid solution (12 mL), and acetone (100 mL) was stirred at room temperature for 20 minutes. The solution was concentrated by rotary evaporation and the residue was partitioned between water (50 mL) and dichloromethane (3*60 mL). The combined dichloromethane layers were dried over sodium sulfate and were concentrated by rotary evaporation. To the residue was added dichloromethane (150 mL), <strong>[53312-79-1]3-amino-4-chloro-benzonitrile</strong> (1.19 g, 7.83 mmol), acetic acid (1.8 mL, 31 mmol), and sodium triacetoxyborohydride (6.74 g, 31.8 mmol), and the solution was stirred at room temperature for 15 hours. The solution was concentrated by rotary evaporation and was partitioned between ethyl acetate (100 mL) and water (50 mL). The ethyl acetate layer was concentrated by rotary evaporation and the residue was purified by flash column chromatography (7:2 hexanes/ethyl acetate) to yield 2.21 g of a white solid. To the white solid was added glacial acetic acid (80 mL), paraformaldehyde (2.34 g, 78.1 mmol), and sodium cyanoborohydride (1.82 g, 6.83 mmol); and the solution was stirred for 17 hours at room temperature. The solution was partitioned between ethyl acetate and saturated sodium bicarbonate solution (1200 mL), and the ethyl acetate layer was concentrated by rotary evaporation. The residue was purified by flash column chromatography (5:1 hexanes/ethyl acetate) to yield 1.82 g (87%) of a cololess oil. 1H NMR (CDCl3): 7.43 (d, J =8.25 Hz, 1H), 7.29 (d, J=1.64 Hz, 1H), 7.21 (dd, JBA=8.24 Hz, JBX=1.93, 1H), 3.68 (s, 3H), 3.08 (t, J=7.42 Hz, 2H), 2.80 (s, 3H), 2.39 (t, J=7.28 Hz, 2H), 1.93 (d, J=7.35 Hz, 2H).

Reference： [1]Patent: US2005/4005,2005,A1 .Location in patent: Page/Page column 35

13
[ 53312-79-1 ]
[ 23095-31-0 ]
[ 1093657-11-4 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2008,vol. 18,p. 5729 - 5733

14
[ 53312-79-1 ]
[ 385432-46-2 ]

Reference： [1]Patent: WO2017/69980,2017,A1
[2]Patent: WO2017/117393,2017,A1

15
[ 53312-79-1 ]
[ 106-95-6 ]
[ 1202512-61-5 ]
[ 1202512-84-2 ]

Reference： [1]Tetrahedron Letters,2009,vol. 50,p. 6968 - 6972

16
[ 53312-79-1 ]
[ 721449-94-1 ]

Reference： [1]Bioorganic and Medicinal Chemistry Letters,2009,vol. 19,p. 4410 - 4415

17
[ 64-18-6 ]
[ 53312-79-1 ]
[ 53313-00-1 ]

Reference： [1]European Journal of Organic Chemistry,2010,p. 2849 - 2851

18
[ 53312-79-1 ]
[ 94568-51-1 ]

Yield	Reaction Conditions	Operation in experiment
20%	With sodium tetrahydroborate; cobalt(II) chloride hexahydrate; In methanol; at 0 - 20℃;	To a solution of AM-1 -3_CN (1.5 g, 10 mmol) in MeOH (50 ml) was added CoCI2.6H20 (4.7 g, 20 mmol). NaBH4 (1 .13 g, 30 mmol) was added in portions to the above mixture at 0 C. The reaction mixture was warmed to r.t. and continued stirring for 12 hrs. The reaction mixture was made pH=13 with NH3.H20 and extracted with EA. The combined organic layer was washed with brine, dried over Na2S04 and concentrated. The crude was purified by column chromatography on silica gel (DCM / MeOH, 9:1 ) to give the product (0.3 g, 20%).
	With ammonia; hydrogen;Ra-Nickel; In methanol; at 20℃; under 2250.23 Torr; for 4h;	(d) 3-Amino-4-chloro-benzylamineA mixture of 3-Amino-4-chloro-benzonitrile (1.32 g, 8.33 mmol), Ra-Nickel (0.25 g) and 80 ml NH3 in MeOH was stirred for 4 h at rt under H2-atmosphere (3 bar). The mixture was filtered and concentrated and the sub-title compound was used without further purification.

Reference： [1]Patent: WO2013/62945,2013,A1 .Location in patent: Page/Page column 104
[2]Patent: WO2010/100249,2010,A1 .Location in patent: Page/Page column 74

19
[ 1246734-24-6 ]
[ 53312-79-1 ]
[ 1246734-17-7 ]

Yield	Reaction Conditions	Operation in experiment
80%		A mixture of <strong>[53312-79-1]4-amino-3-chlorobenzonitrile</strong> (8B, 25 mg, 0.16 mmol) and NaH (60%, 32 mg, 0.80 mmol) in THF (4 mL) was stirred at room temperature for 30 minutes. The reaction was then cooled to 0 0C and a solution of compound 8A (55 mg, 0.16 mmol) in THF (1.5 mL) was added. The reaction was gradually warmed to room temperature and then heated to 85 0C and allowed to stir at this temperature for 18 hours. The reaction mixture was cooled to room temperature and concentrated in vacuo. The residue obtained was purified using preparative thin layer chromatography (20% acetone/hexanes) to provide compound 6 (60 mg, 80 %). M + H = 470.

Reference： [1]Patent: WO2010/114957,2010,A1 .Location in patent: Page/Page column 67-68

20
[ 53312-79-1 ]
[ 132993-24-9 ]
[ 1239578-83-6 ]

Yield	Reaction Conditions	Operation in experiment
60%	With potassium carbonate;tetrakis(triphenylphosphine) palladium(0); triphenylphosphine; In toluene; at 110℃; for 16h;	(1) 4-Chloro-3-(1-nitro-2-naphthylamino)benzonitrile A suspension of 1-nitro-2-naphthyltriflate (1.50 g, 4.67 mmol), <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (1.05 g, 6.87 mmol), potassium carbonate (645 mg, 4.67 mmol), tetrakis(triphenylphosphine)palladium(0) (162 mg, 0.14 mmol) and triphenylphosphine (65 mg, 0.47 mmol) in toluene (45 mL) was stirred at 110C for 16 hours. The reaction mixture was cooled to room temperature, and filtered. The filtrate was diluted with chloroform, washed with 0.2M hydrochloric acid, a saturated aqueous sodium bicarbonate solution and saturated brine. The organic layer was dried over anhydrous sodium sulfate. The solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (hexane/ethyl acetate = 1/1), to give the titled compound (900 mg, yield 60%). 1H-NMR(CDCl3, 400MHz) delta: 7.31(1H, dd, J=2, 8Hz), 7.44(1H, d, J=9Hz), 7.52(1H, t, J=8Hz), 7.58(1H d, J=8Hz), 7.62(1H, d, J=1Hz), 7.68(1H, m), 7.84(1H, d, J=8Hz), 7.96(1H, d, J=9Hz), 8.25(1H, d, J=9Hz), 8.67(1H, br s).

Reference： [1]Patent: EP2397480,2011,A1 .Location in patent: Page/Page column 17-18

21
[ 321-14-2 ]
[ 53312-79-1 ]
[ 1401460-87-4 ]

Reference： [1]Journal of Medicinal Chemistry,2012,vol. 55,p. 8375 - 8391,17

22
[ 53312-79-1 ]
[ 1431960-51-8 ]

Reference： [1]Patent: WO2013/62945,2013,A1

23
[ 53312-79-1 ]
[ 1431959-23-7 ]

Reference： [1]Patent: WO2013/62945,2013,A1

24
[ 85-44-9 ]
[ 53312-79-1 ]
C₁₅H₉ClN₂O₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
12 mg	In ethyl acetate; at 20 - 30℃;	To a solution of phthalic anhydride (1.0 eq) in EtOAc was added <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (1 eq), then was stirred for 1-8 h at 20-30 C. TLC indicated starting material had disappeared. The reaction mixture was filtered and the solid was purified by recrystallization in EtOAc to afford compound I (12 mg). Final product 1 was confirmed by 1H NMR and LCMS. LCMS: Found 301.0 [M+H]. 1H NMR (400 MHz, MeOD-d4): 8.35 (s, 1H), 8.09 (d, J=7.7 Hz, 1H), 7.71 (dd, J=8.0, 4.1 Hz, 1H), 7.67 (d, J=8.4 Hz, 1H), 7.61 (t, J=7.4 Hz. 2H), 7.57 (dd, J=8.4, 2.0 Hz, 1H).

Reference： [1]Patent: US2014/271955,2014,A1 .Location in patent: Paragraph 0739

25
[ 53312-79-1 ]
[ 811-51-8 ]
3-amino-4-ethylsulfanylbenzonitrile [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
93%	In N,N-dimethyl-formamide; at 80℃; for 0.833333h;Microwave irradiation;	[Example 669] Compound o8 3-Amino-4-ethylsulfanylbenzonitrile [1419] Sodium ethanethiolate (1.62 g, 19.27 mmol) was added to a solution of <strong>[53312-79-1]3-amino-4-chlorobenzonitrile</strong> (1.96 g, 12.85 mmol) in DMF (12 ml), and it was stirred at 80C for 50 minutes using a microwave reactor. The reaction solution was cooled to room temperature, and then diluted with EtOAc (250 ml). The resultant solution was washed with 13% saline (100 ml x 3), and the organic layer was then dried over anhydrous sodium sulfate. The drying agent was removed by filtration, followed by concentration under reduced pressure. The resultant residue was purified by amino silica gel column chromatography (EtOAc/n-hexane) to yield the title compound (2.13 g, 93%) as a pale yellow solid. LCMS: m/z 179 [M+H]+ HPLC retention time: 2.00 min (analysis condition D)
93%	In N,N-dimethyl-formamide; at 80℃; for 0.833333h;Microwave irradiation;	DMF solution was 3-amino-4-chlorophenyl-carbonitrile (1.96g, 12.85mmol) of (12ml) was added sodium ethane thiol (1.62g, 19.27mmol), using wave reactor 50 was stirred at 80 C minute. The reaction solution was cooled to room temperature, EtOAc (250ml) was diluted. In the obtained solution, half-saturated brine (100ml, 3 times) After washing, the organic layer was dried over anhydrous sodium sulfate. After the drying agent was filtered off and concentrated under reduced pressure, and the obtained residue was purified by column chromatography over silica gel with amine (EtOAc / n- hexane) to give the title compound (2.1 3g, 93%) as a pale yellow solid.
	In N,N-dimethyl-formamide; at 80℃; for 1.25h;Microwave irradiation;	General procedure: Sodium ethanethiolate (362 mg, 4.3 mmol) was added to a solution of 5-bromo-2-fluorobenzaldehyde (546 mg, 2.7 mmol) in DMF (1.08 ml), and the mixture was stirred at 60C. After one hour, sodium ethanethiolate (123 mg, 1.5 mmol) was added thereto. After 15 minutes, the reaction solution was returned to room temperature, and a 1 N aqueous hydrochloric acid solution was added thereto, and extraction was performed with ethyl acetate. The organic layer was sequentially washed with a saturated aqueous sodium bicarbonate solution and brine, and dried over anhydrous sodium sulfate. The drying agent was removed by filtration, and the residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (ethyl acetate/hexane) to give the title compound (163 mg, 24%) as a yellow oil. The title compound was synthesized from <strong>[53312-79-1]3-amino-4-chloro-benzonitrile</strong> under the same conditions as for Compound 4. However, the reaction was performed by heating at 80C with microwave irradiation.

Reference： [1]Patent: EP2842939,2015,A1 .Location in patent: Paragraph 1419; 1420
[2]Patent: TW2016/5805,2016,A .Location in patent: Paragraph 0330; 0331
[3]Patent: EP2842946,2015,A1 .Location in patent: Paragraph 0204; 0302; 0303

26
[ 623-03-0 ]
[ 53312-79-1 ]

Reference： [1]RSC Advances,2016,vol. 6,p. 23038 - 23047

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P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Ghs Hazard Statements

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere