[ CAS No. 5335-84-2 ]

Name: 5335-84-2|1,2-Bis(4-bromophenyl)disulfane|98%
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Quality Control of [ 5335-84-2 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 5335-84-2 ]

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Alternatived Products of [ 5335-84-2 ]

Product Details of [ 5335-84-2 ]

CAS No. :	5335-84-2	MDL No. :	MFCD00017832
Formula :	C₁₂H₈Br₂S₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	N/A
M.W :	376.13	Pubchem ID :	-
Synonyms :

Computed Properties of [ 5335-84-2 ]

TPSA :Topological Polar Surface Area	-	H-Bond Acceptor Count :	-
XLogP3 :	-	H-Bond Donor Count :	-
SP3 :	-	Rotatable Bond Count :	-

Safety of [ 5335-84-2 ]

Signal Word:	Danger	Class:	8
Precautionary Statements:	P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P310-P332+P313-P362-P403+P233-P405-P501-P273-P391	UN#:	1759
Hazard Statements:	H315-H318-H335-H410	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 5335-84-2 ]

Upstream synthesis route of [ 5335-84-2 ]
Downstream synthetic route of [ 5335-84-2 ]

[ 5335-84-2 ] Synthesis Path-Upstream 1~3

1
[ 5335-84-2 ]
[ 98-58-8 ]

Reference： [1] Synlett, 2009, # 17, p. 2773 - 2776

2
[ 201230-82-2 ]
[ 622-29-7 ]
[ 106-53-6 ]
[ 5335-84-2 ]
[ 27466-83-7 ]
[ 53136-21-3 ]

Reference： [1] Canadian Journal of Chemistry, 1986, vol. 64, p. 2010 - 2012

3
[ 5335-84-2 ]
[ 100-01-6 ]
[ 21969-12-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With tert.-butylnitrite; ascorbic acid In acetonitrile at 20℃; for 4 h; Schlenk technique; Inert atmosphere	General procedure: For solid disulfide: A 10-mL Schlenk tube with a magnetic stirring bar was charged with aniline(0.2 mmol) and disulfide (0.2 mmol). The tube was evacuated and backfilled with dry nitrogen (this operation was repeated three times). Acetonitrile (1 mL) was added by syringe, followed by L-ascorbicacid (0.5 equiv., 20 mg) dissolved in 0.1 mL DMSO. For liquid disulfide: A 10-mL Schlenk tube with a magnetic stirring bar was charged with aniline(0.2 mmol). The tube was evacuated and backfilled with dry nitrogen (this operation was repeated three times). Acetonitrile (1 mL) was added by syringe, followed by disulfide (0.2 mmol or 0.4mmol) and L-ascorbic acid (0.5 equiv., 20 mg) dissolved in 0.1 mL DMSO.The mixture was stirred vigorously for 1 minute before t-BuONO (0.3 mmol, 36 μL) was added via syringe. After the resulting mixture was stirred at 20 °C for 4 hours, the solvent was removed under reduced pressure. Purification of the crude product was achieved by column chromatography

Reference： [1] Synlett, 2015, vol. 26, # 13, p. 1841 - 1846

[ 5335-84-2 ] Synthesis Path-Downstream 1~7

1
[ 67-64-1 ]
[ 98-58-8 ]
palladium [ No CAS ]
[ 5335-84-2 ]
[ 1195-33-1 ]

Reference： [1]Natuurwetenschappelijk Tijdschrift,1933,vol. 15,p. 215

2
[ 422-64-0 ]
[ 5335-84-2 ]
[ 782491-17-2 ]

Reference： [1]Russian Chemical Bulletin,2004,vol. 53,p. 420 - 434

3
[ 928782-97-2 ]
[ 5335-84-2 ]
[ 1285494-96-3 ]

Yield	Reaction Conditions	Operation in experiment
86%	With copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 80℃;	A mixture of 2-alkynylaniline 1a-1e (0.2 mmol), dichalcogenide 2a-2e (0.15 mmol), CuI (0.02 mmol), and Cs2CO3 (0.2 mmol) in DMSO (2 mL) was stirred at 80 C under an air atmosphere. After completion of the reaction that was monitored by GC-MS or TLC, 25 mL water was added, and the mixture was extracted with ethyl acetate, the combined organic layers were washed with water (10 mL x 3), dried over anhydrous Na2SO4. After filtration and removal of solvents in vacuum, the residue was purified by silica gel column chromatography to afford the corresponding products.

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 1343 - 1347

4
[ 5335-84-2 ]
[ 157869-15-3 ]
[ 1285494-88-3 ]

Yield	Reaction Conditions	Operation in experiment
86%	With copper(l) iodide; caesium carbonate; In dimethyl sulfoxide; at 80℃;	A mixture of 2-alkynylaniline 1a-1e (0.2 mmol), dichalcogenide 2a-2e (0.15 mmol), CuI (0.02 mmol), and Cs2CO3 (0.2 mmol) in DMSO (2 mL) was stirred at 80 C under an air atmosphere. After completion of the reaction that was monitored by GC-MS or TLC, 25 mL water was added, and the mixture was extracted with ethyl acetate, the combined organic layers were washed with water (10 mL x 3), dried over anhydrous Na2SO4. After filtration and removal of solvents in vacuum, the residue was purified by silica gel column chromatography to afford the corresponding products.

Reference： [1]Tetrahedron Letters,2011,vol. 52,p. 1343 - 1347

5
[ 40928-13-0 ]
[ 5335-84-2 ]
[ 1423629-75-7 ]

Yield	Reaction Conditions	Operation in experiment
68%	With sodium dithionite; water; potassium carbonate; In dimethyl sulfoxide; at 60℃; for 1.5h;	General procedure: A mixture of isatoic anhydride 1 (0.6 mmol), disulfide 2 (0.2 mmol), and Na2S2O4 (0.9 mmol) in undried DMSO (2 mL) was stirred at 60 C for respective time in Table 2 and Scheme 2. After the completion of the reaction, as monitored by TLC and GC-MS analysis, the reaction mixture washed with brine and extracted with ethyl acetate. The organic phase was separated and dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated and the resulting residue was purified by column chromatography on silica gel (300-400 mesh) with petroleum ether-EtOAc as eluent to provide the desired product.

Reference： [1]Tetrahedron,2013,vol. 69,p. 2283 - 2288

6
[ 5335-84-2 ]
[ 4783-68-0 ]
2-(2-(4-bromophenylthio)phenoxy)pyridine [ No CAS ]

Reference： [1]Journal of Organic Chemistry,2017,vol. 82,p. 12430 - 12438

7
[ 5335-84-2 ]
[ 187344-92-9 ]
S-(4-bromophenyl) bis(3,5-dimethylphenyl)phosphinothioate [ No CAS ]

Reference： [1]Organic and Biomolecular Chemistry,2019,vol. 17,p. 9757 - 9765

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P362	Take off contaminated clothing and wash before reuse.
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P378
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P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
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H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
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H301	Toxic if swallowed
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H311	Toxic in contact with skin
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H314	Causes severe skin burns and eye damage
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H316	Causes mild skin irritation
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H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5335-84-2 ]

Quality Control of [ 5335-84-2 ]

Related Doc. of [ 5335-84-2 ]

Product Details of [ 5335-84-2 ]

Computed Properties of [ 5335-84-2 ]

Safety of [ 5335-84-2 ]

Application In Synthesis of [ 5335-84-2 ]

[ 5335-84-2 ] Synthesis Path-Upstream 1~3

[ 5335-84-2 ] Synthesis Path-Downstream 1~7

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

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