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CAS No. : | 53590-47-9 | MDL No. : | MFCD19301593 |
Formula : | C9H8ClNO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | YXWBLLVBNCUCTI-UHFFFAOYSA-N |
M.W : | 181.62 | Pubchem ID : | 12203316 |
Synonyms : |
|
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 | UN#: | N/A |
Hazard Statements: | H315-H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With manganese(IV) oxide In tetrahydrofuran for 1.5 h; | The product (1 eq.) from above was dissolved in THF (0.5 M) and treated with manganese dioxide (3 eq), and stirred for 1.5 hours until TLC analysis indicated that reaction was complete. The reaction was filtered through celite, dried over magnesium sulfate, and concentrated to yield the desired crude aldehyde in 82percent yield. |
76% | With manganese(IV) oxide In N,N-dimethyl-formamide at 20℃; for 12 h; Inert atmosphere | General procedure: A suspension of the alcohol 12 (1 mmol) and active MnO2(10 mmol) in DMF (30 mL) was stirred at rt for 12 h. The reactionmixture was filtrated through a Celite pad. The filtrate was evaporatedin vacuo. The residue was purified by column chromatographyusing EtOAc-hexane as an eluent to give the indole-2-carbaldehyde 13. |
66% | With manganese(IV) oxide In tetrahydrofuran at 60℃; | General procedure: In round-bottom flask 112 containing the corresponding indole alcohol (1 eq.) in THF, 6 eq. of freshly prepared 113 MnO2 were added and the reaction was kept under magnetic stirring at 60 C, until the 114 completion of the reaction was detected by TLC (2 – 4 hours). The reaction mixture was 115 filtered through a quantitative filter paper (pore size of 8 μm), washed with THF, followed by MeOH and the filtered was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
80% | With lithium aluminium tetrahydride; In tetrahydrofuran; at 20℃; for 5.0h;Cooling with ice; | General procedure: A solution of indole-2-carboxylate 11 (1 mmol) in THF (10 mL)was added dropwise to a suspension of LiAlH4 (0.8 mmol) in THF(20 mL) under cooling with ice-water. After stirring at rt for 5 h, thereaction mixture was quenched with water, and then was filtratedthrough a Celite pad. The filtrate was extracted with EtOAc. Theorganic layer was washed with brine, dried over Na2SO4, andevaporated in vacuo. The residue was purified by column chromatography using EtOAc-hexane as an eluent to give thealcohol 12. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20℃; | General procedure: To a slurry of lithium aluminum hydride (1.00 g, 26.3 mmol) in anhydrous tetrahydrofuran (50 mL) which was cooled to 0 C was added a solution of ethyl 1H-indole-2-carboxylate (3.80 g, 20.0 mmol) in tetrahydrofuran (50 mL) dropwise at 0 C while stirring. The temperature of the mixture was then warmed naturally to room temperature and the mixture was stirred at room temperature overnight. The resulting mixture was quenched with methanol, and then filtered through a celite pad. The filtrate was concentrated in vacuo to afford 1.5 g of 1H-indol-2- ylmethanol. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
97% | With lithium aluminium tetrahydride; In tetrahydrofuran; | General procedure: In round-bottom flask94 containing the correspondent indole ester (1 eq.) in THF, LiAlH4 (4 eq.) was added in an95 ice bath under stirring. The ice bath was removed and the reaction was kept under96 magnetic stirring until the completion of the reaction was detected by TLC (1 hour). Then, in an ice bath, the reaction was quenched with distilled water diluted in THF, followed 97 by 4 eq. of 1 M NaOH solution and finally three times this volume of distilled water. The 98 suspension was stirred for 10 min, when the white precipitate was filtered off and washed 99 with THF. The filtrate was partially evaporated under reduced pressure and the remaining 100 solution was extracted with 2 x 20 mL AcOEt. The organic layer was collected, dried 101 with Na2SO4, filtered and the solvent evaporated under reduced pressure. |
84.9% | With lithium aluminium tetrahydride; In tetrahydrofuran; for 2.0h; | Ethyl 5-chloro-1 H-indole-2-carboxylate (2.0 g; 8.763 mmol; commercial from CombiBlocks) is dissolved in dry THF (20 ml_), treated at 0C with a 2M lithium aluminium hydride solution in THF (5.258 ml10.516 mmol) and stirred for 2 h. The reaction mixture is quenched at 0C by addition of water, diluted with EtOAc, stirred for 30 min and filtered. The phases are separated and the water phase is extracted with EtOAc (3*20 ml_). The combinded organic phases are concentrated under reduced pressure, diluted with ACN/water and purified by preparative RP-HPLC using an ACN/water (25-98% ACN, acidic conditions) gradient. The product containing fractions are combined and freeze dried to yield (5-chloro-1 H-indol-2- yl)methanol (1.352 g; 7.444 mmol; 84.9%). HPLC method: LCMSBAS1 : [M-H]+ = 180; tret [min] = 0.94 min. |
72% | With lithium borohydride; In tetrahydrofuran; at 0 - 20℃; for 16.0h;Inert atmosphere; | [0575] To a stirred solution of ethyl 5-chloro-1H-indole-2-carboxylate (3 g, 13 mmol) in THF (60 mL) at 0 C under an argon atmosphere was added 2M LiBH4 in THF (582 mg, 27 mmol). The reaction mixture was warmed to room temperature and stirred for 16 h. After consumption of starting material (by TLC), the reaction mixture was diluted with saturated ammonium chloride solution (20 mL) and extracted with EtOAc (2 x 30 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo to obtain (5-chloro-1H-indol-2-yl) methanol (1.75 g, 72%) as an off white solid used in the next step without further purification.‘H NMR (DMSO-d6, 500 MHz): 11.20 (brs, 1H), 7.49 (s, 1H), 7.32 (d, 1H), 7.01 (dd, 1H), 6.26 (s, 1H), 5.29 (t, 1H), 4.60 (d, 2H); TLC: 30% EtOAc/ Hexane (Rj: 0.3). |
5-Chloro-1H-indole-2-carboxylic acid ethyl ester (1 eq.) was dissolved in THF (0.4M), flushed with a nitrogen atmosphere and then the mixture was cooled to 0 C. and LAH (3 eq of a 1M solution in THF) was slowly added. The reaction was allowed to warm slowly to room temperature and stirred until TLC analysis indicated completion. After cooling the flask to 0 C., NaOH (60 ml 3N solution) was slowly added and the reaction stirred until two layers were obtained. The layers were separated, aqueous was extracted 2× ethyl acetate, the combined organics were washed with brine and then dried over magnesium sulfate and concentrated to yield the desired alcohol that was used crude for the next step. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
82% | With manganese(IV) oxide; In tetrahydrofuran; for 1.5h; | The product (1 eq.) from above was dissolved in THF (0.5 M) and treated with manganese dioxide (3 eq), and stirred for 1.5 hours until TLC analysis indicated that reaction was complete. The reaction was filtered through celite, dried over magnesium sulfate, and concentrated to yield the desired crude aldehyde in 82% yield. |
76% | With manganese(IV) oxide; In N,N-dimethyl-formamide; at 20℃; for 12h;Inert atmosphere; | General procedure: A suspension of the alcohol 12 (1 mmol) and active MnO2(10 mmol) in DMF (30 mL) was stirred at rt for 12 h. The reactionmixture was filtrated through a Celite pad. The filtrate was evaporatedin vacuo. The residue was purified by column chromatographyusing EtOAc-hexane as an eluent to give the indole-2-carbaldehyde 13. |
66% | With manganese(IV) oxide; In tetrahydrofuran; at 60℃; | General procedure: In round-bottom flask 112 containing the corresponding indole alcohol (1 eq.) in THF, 6 eq. of freshly prepared 113 MnO2 were added and the reaction was kept under magnetic stirring at 60 C, until the 114 completion of the reaction was detected by TLC (2 - 4 hours). The reaction mixture was 115 filtered through a quantitative filter paper (pore size of 8 mum), washed with THF, followed by MeOH and the filtered was evaporated under reduced pressure. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With sodium hydrogencarbonate; In diethyl ether; ethyl acetate; N,N-dimethyl-formamide; | Step 2: Two solutions were prepared under N2. The first consisted of a 19M solution (based on imidazole) of DMF containing 1.2 eq tert-butyldimethylsilyl chloride, and 2.5 eq imidazole. The second was 1 eq <strong>[53590-47-9](5-chloro-1H-indol-2-yl)methanol</strong> dissolved in DMF (2.5M). The second solution (<strong>[53590-47-9](5-chloro-1H-indol-2-yl)methanol</strong> in DMF) was added to the first solution and some smoke/steam was evolved. Formed a red-brown solution and was left stirring at rt overnight. Reaction was quenched with a saturated sodium bicarbonate aqueous solution and extracted with a 4:1 mixture of ethyl acetate and diethyl ether. Organic phase was washed with water and brine and dried over Na2SO4. Solvent was removed to give 2-([tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-1H-indole (orange solid) in 99% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
85% | With LiAlH4; In tetrahydrofuran; water; | Step 1: Ethyl 5-chloro-2-indole-carboxylate (1 eq) was dissolved in THF (0.45M) under N2. This solution was cooled to 0 C. for fifteen minutes and then 1.1 eq LiAlH4 (1M in THF) was added. The resulting dark brown solution was allowed to return to rt with stirring and kept overnight. Then water (1/25 of the volume of the LiAlH4 solution) was added slowly, followed by 15% NaOH(aq) (1/25 of the volume of the LiAlH4 solution) solution. Finally, water (1/25 of the volume of the LiAlH4 solution) was added along with a large amount of MgSO4. Solution was filtered and the solid was washed with EtOAc and the filtrate was collected. Solvent was stripped off to give (5-chloro-1H-indol-2-yl)methanol (yellow solid) in 85% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
34.7% | With Ce2CO3; In N,N-dimethyl-formamide; at 30 - 50℃; | Step 1: synthesis of [5-chloro- 1 -(2-methanesulfonyl-ethyl)- 1H-indol-2-yl] -methanol To a solution of (5-chloro-1H-indol-2-yl)-methanol (3.6 g, 0.02 mol), Ce2CO3(13 g,0.04 mol) in 100 mL of DMF which was cooled to 0 C, was added methanesulfonyl-ethene (2.1 g, 0.02 mol)in portions. The reaction mixture was stirred at a temperature between 30C and 50 C overnight.Ice-water was then added to the mixture, the precipitate was filtered and dried to give [5-chloro-1- (2-methanesulfonyl-ethyl)- 1H-indol-2-yl] -methanol (2 g, yield: 34.7%). |
34.7% | With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 50℃; | Step 1: synthesis of [5-chloro-1-(2-methanesulfonyl-ethyl)-1H-indol-2-yl]-methanol To a solution of (5-chloro-1H-indol-2-yl)-methanol (3.6 g, 0.02 mol), Ce2CO3 (13 g, 0.04 mol) in 100 mL of DMF which was cooled to 0 C., was added methanesulfonyl-ethene (2.1 g, 0.02 mol) in portions. The reaction mixture was stirred at a temperature between 30 C. and 50 C. overnight. Ice-water was then added to the mixture, the precipitate was filtered and dried to give [5-chloro-1-(2-methanesulfonyl-ethyl)-1H-indol-2-yl]-methanol (2 g, yield: 34.7%). |
34.7% | With caesium carbonate; In N,N-dimethyl-formamide; at 0 - 50℃; | To a solution of (5-chloro-1H-indol-2-yl)-methanol (3.6 g, 0.02 mol), Ce2CO3 (13 g, 0.04 mol) in 100 mL of DMF which was cooled to 0 C., was added methanesulfonyl-ethene (2.1 g, 0.02 mol) in portions. The reaction mixture was stirred at a temperature between 30 C. and 50 C. overnight. Ice-water was then added to the mixture, the precipitate was filtered and dried to give [5-chloro-1-(2-methanesulfonyl-ethyl)-1H-indol-2-yl]-methanol (2 g, yield: 34.7%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
2 g | With 1H-imidazole; In dichloromethane; at 0 - 20℃;Inert atmosphere; | To a cooled solution of (5-chloro-lH-indol-2-yl)methanol (1.82 g, 10.0 mmol) in dichloromethane (20 mL) at 0 C in an ice bath was added a solution of imidazole (1.0 g, 15.0 mmol) in dichloromethane (20 mL) slowly and then followed by addition of a solution of tert- butyl(chloro)dimethylsilane (2.26 g, 15.0 mol) in dichloromethane (10 mL) dropwise under nitrogen atmosphere. After being stirred for 15 minutes, the mixture was allowed to warm to room temperature and then stirred at room temperature overnight. The reaction mixture was then diluted with dichloromethane (50 mL) and then washed with water (50 mL) and brine (50 mL). The organic layer was dried over sodium sulfate and then concentrated in vacuo. The residue was purified by flash chromatography (eluting with 5% ethyl acetate in petroleum ether) to give 2.0 g of 2-([tert-butyl(dimethyl)silyl]oxy}methyl)-5-chloro-lH-indole as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With 1,3-dichloro-5,5-dimethylhydantoin; In ethyl acetate; at 25℃; for 0.25h; | A 25 mL round bottom flask was charged with 36.2 mg of 5-chloro-1-hydro-indole-2-methanol, 8 mL of ethyl acetate,Chloro-5,5-dimethylhydantoin (DCDMH) 43.3 mg was stirred at 25 C for 15 minutes. After the completion of the reaction, the solvent was removed by rotary evaporation, and column chromatography was carried out to obtain 37.9 mg of 3,5-dichloro-1-hydro-indole-2-carbaldehyde in 89% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
70% | With N-Bromosuccinimide; at 25℃; for 0.08333330000000001h; | A 25 mL round bottom flask was charged with 45.0 mg of 5-bromo-1-hydrogen-indole-2-methanol, 8 mL of ethyl acetate, 78.3 mg of N-bromosuccinimide (NBS), stirred at 25 C 5 minutes. After the completion of the reaction, the solvent was removed by rotary evaporation and chromatographed to give 5-chloro-3-bromo-1-hydro-indole-2-carbaldehyde 36.0mg in 70% yield. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
74% | With 18-crown-6 ether; potassium hydroxide; In dichloromethane; at 0 - 20℃; for 12.0h;Inert atmosphere; | General procedure: A stirred solution of (1H-indol-2-yl)methanol compounds 1a-h (0.24 mmol) in dichloromethane (3 mL) was treated with potassium hydroxide (16.8 mg, 0.30 mmol) and 18-crown-6 (79.30 mg, 0.30 mmol) at 0 C under argon. After 10 min a solution of vinyl selenones 2a-e (0.12 mmol) in dichloromethane (3 mL) was added at 0 C and the reaction mixtures were allowed to warm to rt. The progress of the reactions were monitored by TLC. After 12 h the solvent was evaporated under vacuum. The products were purified using column chromatography on silica gel (EtOAc/PE 5:95 as eluant) afford the oxazine derivates 3a-r. The physical and spectral data of the 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indoles 3a-f are identical to those reported in the literature.4c The physical and spectral data of 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indoles 3g-r are reported below. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
50% | With 18-crown-6 ether; potassium hydroxide; In dichloromethane; at 0 - 20℃; for 24.0h;Inert atmosphere; | General procedure: A stirred solution of (1H-indol-2-yl)methanol compounds 1a-h (0.24 mmol) in dichloromethane (3 mL) was treated with potassium hydroxide (16.8 mg, 0.30 mmol) and 18-crown-6 (79.30 mg, 0.30 mmol) at 0 C under argon. After 10 min a solution of vinyl selenones 2a-e (0.12 mmol) in dichloromethane (3 mL) was added at 0 C and the reaction mixtures were allowed to warm to rt. The progress of the reactions were monitored by TLC. After 12 h the solvent was evaporated under vacuum. The products were purified using column chromatography on silica gel (EtOAc/PE 5:95 as eluant) afford the oxazine derivates 3a-r. The physical and spectral data of the 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indoles 3a-f are identical to those reported in the literature.4c The physical and spectral data of 3,4-dihydro-1H-[1,4]oxazino[4,3-a]indoles 3g-r are reported below. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
58% | With potassium hydroxide; diphenyl(vinyl)sulfonium trifluoromethanesulfonate; In dichloromethane; at 0 - 20℃; for 16.0h;Inert atmosphere; | [0576] To a stirred solution of 5-chloro-1H-indole-2-carboxylic acid (800 mg, 4 mmol) in CH2C12 (280 mL) at 0 C under an argon atmosphere was added potassium hydroxide (618 mg, 11 mmol). Then ((trifluoromethyl) sulfonyl)-l1-oxidane compound with diphenyl (vinyl)-13-sulfane (1.92 g, 5 mmol) in CH2C12 (200 mL) was added to the reaction mixture at 0 C. The reaction mixture was warmed to room temperature and stirred for 16 h. After consumption of starting material (by TLC), the volatiles were concentrated in vacuo. The crude material was purified by column chromatography using 5% EtOAc: Hexane to afford 8-chloro-3,4-dihydro-1H-[1,4j oxazino [4,3-aj indole (530 mg, 58%) as an off-white solid. LCMS: 99.3%; 208 (M+1); (column; X-select CSH C-18 (50 x 3.0 mm, 2.5 jtm); RT 3.38 mm; mobile phase: 2.5 mlvi Aq NH400CH in water +5% ACN: ACN+5% 2.5 mM NH400CH in water; T/B%: 0.01/5, 0.5/5, 3.5/100, 6/100; flow rate: 0.8 mL/min) (Gradient); TLC: 20% EtOAc/ Hexane (Rj: 0.6). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
60% | With ammonium hydroxide; at 85℃; | A suspension of (5-chloro-1 H-indol-2-yl)methanol (150 mg; 826 pmol), methyl 2-formyl-4- hydroxy-benzoate (148.79 mg; 826 pmol) and ammonia solution (28% in water; 1.175 ml8.26 mmol) in water (1.5 ml_) is stirred and heated at 85C overnight. The reaction mixture is diluted with DMF, filtrated and purified by preparative RP-HPLC using a ACN/water gradient (20-90%) as eluent to give 3-[5-chloro-2-(hydroxymethyl)-1 H-indol-3-yl]-5-hydroxy- 2,3-dihydro-1 H-isoindol-1-one (163 mg; 496 pmol; 60.0%). HPLC method: LCMSBAS1 : [M+H]+ = 329; tret [min] = 0.67 min |
Tags: 53590-47-9 synthesis path| 53590-47-9 SDS| 53590-47-9 COA| 53590-47-9 purity| 53590-47-9 application| 53590-47-9 NMR| 53590-47-9 COA| 53590-47-9 structure
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P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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