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Chemical Structure| 53704-63-5 Chemical Structure| 53704-63-5

Structure of 53704-63-5

Chemical Structure| 53704-63-5

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Product Details of [ 53704-63-5 ]

CAS No. :53704-63-5
Formula : C11H12N2O
M.W : 188.23
SMILES Code : CCOC1=CC=C(C2=CNC=N2)C=C1

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Application In Synthesis of [ 53704-63-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53704-63-5 ]

[ 53704-63-5 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 71759-89-2 ]
  • [ 22237-13-4 ]
  • [ 53704-63-5 ]
YieldReaction ConditionsOperation in experiment
67% With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-benzyl-N,N,N-triethylammonium chloride; cesium fluoride; In water; toluene; at 120℃; for 1h;Microwave irradiation; Inert atmosphere; General procedure: Method A: In a20 mL microwave Biotage tube, a mixture of 4-iodo-1H-imidazole(1a) (0.194 g, 1.0 mmol), a boronic acid 2(2.0 mmol), CsF (0.456 g,3.0 mmol), PdCl2(dppf)(0.041 g, 0.05 mmol) and BnEt3NCl(0.011 g, 0.05 mmol) in toluene(7 mL) and water (7 mL)was purged with argon andheated under microwaveirradiation. When the reaction was complete, the mixture was cooled toroom temperature and concentrated under reduced pressure. The residue waspurified by flash chromatography on silica gel to provide compounds 3a-3i and 3k-3o in yields ranging from 40 to 91%. Time and temperaturereactions were collected in Table 1.
 

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