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Chemical Structure| 53733-94-1 Chemical Structure| 53733-94-1

Structure of 53733-94-1

Chemical Structure| 53733-94-1

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Product Details of [ 53733-94-1 ]

CAS No. :53733-94-1
Formula : C14H19NO4
M.W : 265.31
SMILES Code : O=C(OC)CCN(CCC(OC)=O)C1=CC=CC=C1
MDL No. :MFCD07368276

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Application In Synthesis of [ 53733-94-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 53733-94-1 ]

[ 53733-94-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 292638-85-8 ]
  • [ 62-53-3 ]
  • [ 53733-94-1 ]
  • [ 21911-84-2 ]
YieldReaction ConditionsOperation in experiment
1%; 97% With aluminum oxide; at 100 - 110℃; for 3h; General procedure: The amine 1 (15mmol) and methyl propenoate 2 (10mmol) were pipetted into a round bottomed flask equipped with a magnetic bar and a reflux condenser. Acidic alumina (2g, 200mol%) was then introduced in the flask at room temperature by means of a plastic funnel. The mixture was heated to reflux by using an oil bath. The reaction was followed by TLC and GC analysis. On completion the mixture was allowed to cool to room temperature. The mixture was then filtered through a filter paper and the catalyst rinsed with diethyl ether. The filtrate was concentrated by rotary evaporation and then purification of the mono-adduct was done using gravity column chromatography on silica gel. For aliphatic amines, the bis-adduct side product was primarily eluted using 75:25 of hexane and ethyl acetate. As soon as the bis-adduct was eluted, the eluent's polarity was increased to 50:50 of hexane and ethyl acetate to elute the remaining mono-adduct. On the other hand, for aromatic amines, the mono-adduct was the first to elute out of the column, and was eluted using only 80:20 of hexane and ethyl acetate, respectively. The yields of the purified adducts 3 were finally recorded and characterisation was done using IR and NMR spectroscopy.
 

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