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CAS No. : | 5382-30-9 | MDL No. : | MFCD03064901 |
Formula : | C9H19NO | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | - |
M.W : | 157.25 | Pubchem ID : | - |
Synonyms : |
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TPSA :Topological Polar Surface Area | - | H-Bond Acceptor Count : | - |
XLogP3 : | - | H-Bond Donor Count : | - |
SP3 : | - | Rotatable Bond Count : | - |
Signal Word: | Class: | ||
Precautionary Statements: | UN#: | ||
Hazard Statements: | Packing Group: |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
51% | With pyridine In chloroform at 20℃; | [003191 48A. tert-Butyl 4-(tosyloxy)piperidine-1-carboxylate: To an ice cooled solution of tert-butyl-4-hydroxy-piperdine (3.00 g, 14.9 mmol) in CHC13 (30 mL), pyridine (3.6 mL, 45 mmol) and TsC1 (5.68 g, 29.8 mmol) were added and the reactionmixture was stirred at rt overnight. The reaction mixture was diluted with CHC13, washed with 1.5 N aq. HC1 and brine, dried over Na2SO4, and concentrated. Purification via silica chromatography gave 48A (off-white solid, 2.70 g, 7.61 mmol, 51percent yield). LC-MS-Anal. Calc’d for C17H25N05S: 355.15, found [M+Na] 377.9. ‘HNMR(400 MHz, DMSO-d6) ö 7.83 (d, J=7.8 Hz, 2H), 7.49 (d, J=7.8 Hz, 2H), 4.69 (tt, J8.0, 3.8Hz, 1H), 3.49 (ddd, J=13.4, 6.5, 4.1 Hz, 2H), 3.15 (t, J9.4 Hz, 2H), 2.44 (s, 3H), 1.67 -1.75 (m, 2H), 1.45 - 1.54 (m, 2H), 1.38 (s, 9H). |