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Chemical Structure| 54-62-6 Chemical Structure| 54-62-6

Structure of Aminopterin
CAS No.: 54-62-6

Chemical Structure| 54-62-6

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Aminopterin is a 4-amino derivative of folate that acts as a competitive inhibitor of dihydrofolate reductase, exhibiting anticancer and immunosuppressive activities, mainly used in pediatric leukemia research.

Synonyms: 4-Aminofolic acid; APGA; NSC 739

4.5 *For Research Use Only !

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Product Details of Aminopterin

CAS No. :54-62-6
Formula : C19H20N8O5
M.W : 440.41
SMILES Code : NC1=NC(N)=NC2=C1N=C(CNC3=CC=C(C=C3)C(N[C@H](C(O)=O)CCC(O)=O)=O)C=N2
Synonyms :
4-Aminofolic acid; APGA; NSC 739
MDL No. :MFCD00036692
InChI Key :TVZGACDUOSZQKY-LBPRGKRZSA-N
Pubchem ID :169371

Safety of Aminopterin

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H300-H360
Precautionary Statements:P201-P202-P264-P270-P280-P301+P310+P330-P308+P313-P405-P501
Class:6.1
UN#:2811
Packing Group:

Isoform Comparison

Biological Activity

Description
Aminopterin (4-Aminofolic acid), a 4-amino derivative of folic acid, antagonizes folic acid by catalyzing its reduction to tetrahydrofolic acid and competitively inhibiting dihydrofolate reductase (DHFR) with a Ki of 3.7 pM. Aminopterin possesses anticancer and immunosuppressive properties and is employed in the treatment of pediatric leukemia[1][2].

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.27mL

0.45mL

0.23mL

11.35mL

2.27mL

1.14mL

22.71mL

4.54mL

2.27mL

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