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Chemical Structure| 544461-27-0 Chemical Structure| 544461-27-0

Structure of 544461-27-0

Chemical Structure| 544461-27-0

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Product Details of [ 544461-27-0 ]

CAS No. :544461-27-0
Formula : C11H12N2O2S
M.W : 236.29
SMILES Code : CSC1=C2C=C(OC)C(OC)=CC2=NC=N1

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Application In Synthesis of [ 544461-27-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 544461-27-0 ]

[ 544461-27-0 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 616-38-6 ]
  • [ 13790-39-1 ]
  • [ 544461-27-0 ]
YieldReaction ConditionsOperation in experiment
85% With potassium tert-butylate; palladium diacetate; triphenylphosphine; potassium thioacetate; In dimethyl sulfoxide; at 120℃;Inert atmosphere; Under a nitrogen atmosphere,The substrate <strong>[13790-39-1]4-chloro-6,7-dimethoxyquinazoline</strong> 1r (0.2 mmol, 44.8 mg) was added to a 25 mL test tube reactor,KSAc(0.6mmol,68.4mg),DMC(1.0mmol,90mg),Pd(OAc)2(0.01mmol,2.3mg),PPh3(0.02mmol,5.9mg),tBuOK(0.6mmol,69.2mg),and DMSO(2.0mL).were added and the reaction was heated to 120 C to carry out the reaction.After the TLC detection reaction was completed,The system was cooled to room temperature.The reaction was quenched with saturated aqueous ammonium chloride,And extracted with ethyl acetate (3 * 10 mL)Column chromatography gave the product 2 r 40.1 mg (85%).
 

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