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CAS No. : | 5464-68-6 | MDL No. : | MFCD00014805 |
Formula : | C6H14NO4P | Boiling Point : | - |
Linear Structure Formula : | - | InChI Key : | QPVCUQOSWAXEOQ-UHFFFAOYSA-N |
M.W : | 195.15 | Pubchem ID : | 225722 |
Synonyms : |
|
Num. heavy atoms : | 12 |
Num. arom. heavy atoms : | 0 |
Fraction Csp3 : | 0.83 |
Num. rotatable bonds : | 6 |
Num. H-bond acceptors : | 4.0 |
Num. H-bond donors : | 1.0 |
Molar Refractivity : | 44.7 |
TPSA : | 88.43 Ų |
GI absorption : | High |
BBB permeant : | No |
P-gp substrate : | No |
CYP1A2 inhibitor : | No |
CYP2C19 inhibitor : | No |
CYP2C9 inhibitor : | No |
CYP2D6 inhibitor : | No |
CYP3A4 inhibitor : | No |
Log Kp (skin permeation) : | -8.09 cm/s |
Log Po/w (iLOGP) : | 1.0 |
Log Po/w (XLOGP3) : | -0.85 |
Log Po/w (WLOGP) : | 0.74 |
Log Po/w (MLOGP) : | -0.58 |
Log Po/w (SILICOS-IT) : | -0.62 |
Consensus Log Po/w : | -0.06 |
Lipinski : | 0.0 |
Ghose : | None |
Veber : | 0.0 |
Egan : | 0.0 |
Muegge : | 1.0 |
Bioavailability Score : | 0.55 |
Log S (ESOL) : | -0.12 |
Solubility : | 149.0 mg/ml ; 0.761 mol/l |
Class : | Very soluble |
Log S (Ali) : | -0.53 |
Solubility : | 58.1 mg/ml ; 0.298 mol/l |
Class : | Very soluble |
Log S (SILICOS-IT) : | -0.96 |
Solubility : | 21.3 mg/ml ; 0.109 mol/l |
Class : | Soluble |
PAINS : | 0.0 alert |
Brenk : | 1.0 alert |
Leadlikeness : | 1.0 |
Synthetic accessibility : | 3.44 |
Signal Word: | Warning | Class: | N/A |
Precautionary Statements: | P305+P351+P338 | UN#: | N/A |
Hazard Statements: | H319 | Packing Group: | N/A |
GHS Pictogram: |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | for 3.5 h; Reflux | 2-Chloroacetamide (5.01 g, 53.6 mmol) and triethyl phosphite (9.19 mL, 53.6 mmol) were heated at reflux in o-xylene (14 mL) for 3.5 h. The solvent was removed under reduced pressure to afford a dark brown tar-like residue. The residue was taken up in dichloromethane and filtered through a short column of silica. The filtrate was concentrated and the solid recrystallised from ethyl acetate/pentane to afford diethyl carbamoylmethylphosphonate (3.42 g, 33percent) as light brown crystals. ‘H NMR (200 MHz, DMSO-d6) ö 7.35 (br s, 1H); 7.02 (br s, 1H); 4.02 (dq, 4H, J=7.1 Hz, JpH=1.1 Hz); 2.80(d, 2H, JPH =21.4 Hz); 1.23 (t, 6H, J=7.0 Hz). ‘3C NMR (50 MHz, DMSO-d6) ö 166.0(d, 2Jcp5.1 Hz); 61.5 (d, 2J=6.0 Hz); 34.5 (d, ‘Jp131.6 Hz); 16.2 (d, 3J=6.0 Hz).3’P NMR (81 MHz, DMSO-d6) 23.8. ESIMS: m/z 218 [M+Na]. HRMS calcd forC6H,4N04P 195.0655, found 195.0653. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
33% | In o-xylene; for 3.5h;Reflux; | 2-Chloroacetamide (5.01 g, 53.6 mmol) and triethyl phosphite (9.19 mL, 53.6 mmol) were heated at reflux in o-xylene (14 mL) for 3.5 h. The solvent was removed under reduced pressure to afford a dark brown tar-like residue. The residue was taken up in dichloromethane and filtered through a short column of silica. The filtrate was concentrated and the solid recrystallised from ethyl acetate/pentane to afford diethyl carbamoylmethylphosphonate (3.42 g, 33%) as light brown crystals. ?H NMR (200 MHz, DMSO-d6) oe 7.35 (br s, 1H); 7.02 (br s, 1H); 4.02 (dq, 4H, J=7.1 Hz, JpH=1.1 Hz); 2.80(d, 2H, JPH =21.4 Hz); 1.23 (t, 6H, J=7.0 Hz). ?3C NMR (50 MHz, DMSO-d6) oe 166.0(d, 2Jcp5.1 Hz); 61.5 (d, 2J=6.0 Hz); 34.5 (d, ?Jp131.6 Hz); 16.2 (d, 3J=6.0 Hz).3?P NMR (81 MHz, DMSO-d6) 23.8. ESIMS: m/z 218 [M+Na]. HRMS calcd forC6H,4N04P 195.0655, found 195.0653. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium tert-butylate; In tetrahydrofuran; water; ethyl acetate; | Preparation 37-1) To a solution of <strong>[5464-68-6]diethyl carbamoylmethylphosphonate</strong> (12.7 g) and potassium tert-butoxide (13.9 g) in tetrahydrofuran (400 ml) were added a solution of (2R,4R)-1-allyloxycarbonyl-4-tert-butyldimethylsilyloxy-2-{2-(4-formylimidazol-1-yl)ethyl}pyrrolidine (24 g) in tetrahydrofuran (50 ml) at 45 C. After stirring for 1 hour, to the reaction mixture were added water (3 ml). Evaporation of the solvent gave a residue, which was dissolved in a mixture of ethyl acetate (500 ml) and water (50 ml). The organic layer was separated, washed in turn with water (50 ml*2) and brine (50 ml*2), and dried over magnesium sulfate. Evaporation of the solvent gave an oil, which was chromatographed on silica gel (500 ml) eluding with a mixture of dichloromethane and methanol (10:1) to give (2R,4R)-1-allyloxycarbonyl-4-tert-butyl-dimethylsilyloxy-2-[2-{4-(2-carbamoylethenyl)imidazol-1-yl}ethyl]pyrrolidine (13.87 g). NMR (CDCl3, delta): 0.38 (6H, s), 0.85 (9H, s), 1.50-1.75 (1H, m), 1.80-2.10 (2H, m), 2.17-2.35 (1H, m), 3.33-3.50 (2H, m), 3.90-4.20 (3H, m), 4.30-4.35 (1H, m), 4.50-4.61 (2H, m), 5.18-5.34 (2H, m), 5.57 (2H, br s), 5.83-6.02 (1H, m), 6.61 (1H, d, J=15.2 Hz), 7.11 (1H, br s), 7.50 (1H, d, J=15.0 Hz), 7.51 (1H, br s) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
71.5% | With dimethyl sulfoxide; triethylamine; In tetrahydrofuran; hexane; dichloromethane; di-isopropyl ether; ethyl acetate; | REFERENCE EXAMPLE 4-1) (E)-3-[(2S,4S)-N-Allyloxycarbonyl-4-tritylthiopyrrolidin-2-yl]acrylamide STR365 To a solution of dimethyl sulfoxide (49.9 ml, 703 mmol) in methylene chloride (1.1 l) was added oxalyl chloride (32.1 ml, 376 mmol) at -70 C., and the reaction mixture stirred for 30 minutes, treated with a pre-cooled (-70 C.) solution of (2S,4S)-N-allyloxycarbonyl-2-hydroxymethyl-4-tritylthiopyrrolidine(115.3 g, 251 mmol) in methylene chloride (400 ml), and stirred for 30 minutes. The mixture was treated with triethylamine (174.9 ml, 1.25 mol), stirred for 30 minutes, and stirred for additional 30 minutes after removing an ice-bath. The mixture was poured into water (500 ml), the organic layer washed with lM sodium dihydrogen phosphate (500 ml) and saturated sodium bicarbonate, dried over anhydrous sodium sulfate, and concentrated in vacuo. A solution of the obtained residue and 2-(diethylphosphono)acetamide (63.6 g, 326 mmol) in tetrahydrofuran (1.6 l) was treated with 60% sodium hydride (11 g, 275 mmol) under ice-cooling, and the reaction mixture stirred for 30 minutes, and concentrated. The residue was dissolved in ethyl acetate (1.5 l), washed successively with water (1 l and 500 ml) and saturated aqueous sodium chloride, dried over anhydrous sodium sulfate, and concentrated. The residual solid was collected by filtration after addition of diisopropyl ether (600 ml), recrystallized from a mixture of ethyl acetate (700 ml) and hexane (700 ml) to give the title compound (79.2 g), and the mother liquor was purified by flash column chromatography on silica gel (Wakogel C-300, 400 ml, elution with ethyl acetate) to give a second crop (combined weight 89.4 g, 71.5% total yield). NMR(CDCl3) delta: 1.54(1H,m), 2.1(1H,m), 2.7-3.4(3H,m), 4.18(1H,q,J=8 Hz), 4.3-4.5(2H,m), 5.1-5.3(2H,m), 5.42(2H,brs), 5.7-5.9(2H,m), 6.62(1H,dd,J=8,15 Hz), 7.2-7.6(15H,m) |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
0.016 g | A mixture of <strong>[5464-68-6]diethyl 2-amino-2-oxoethylphosphonate</strong> (0.083 g, 0.43 mmol) in DMF (2.5 mL), was added NaH (60% mineral oil dispersion, 0.015 g, 0.57 mmol) and the mixture stirred at 5 C under nitrogen. After 15 min, a solution 4-(4,4-difluoro-cyclohexyloxy)- 7H-pyrrolo[2,3-d]pyrimidine-5-carbaldehyde (Step A, 0.100 g, 0.35 mmol), in DMF (1 mL) was added dropwise. After stirring at room temperature for 12 h, the reaction was quenched by the addition of 5% citric acid (5 mL) and extracted with ethyl acetate (2 x 10 mL). The combined extracts were washed with brine, dried over MgS04, filtered and concentrated under reduced pressure. The resulting residue was purified by flash chromatography (0-95% gradient ethyl acetate in heptane) to afford 0.016 g of 3-[4-(4,4-difluoro-cyclohexyloxy)-7H-pyrrolo[2,3- d]pyrimidin-5-yl]-acrylamide: 1H-NMR (400 MHz, DMSO-d6) delta 12.44 (br s, 1 H), 8.43 (s, 1 H), 8.15 (s, 1 H), 7.92 (s, 2 H), 7.81 (d, / = 16.0 Hz, 1 H), 6.34 (d, / = 16.0 Hz, 1 H), 4.37 (m, 1 H), 2.61 (m, 2 H), 2.18 (m, 2 H), 1.93 (m, 2 H), 1.7 (m, 2 H); LCMS (ES) m/z 323 (M+H). [00306] Example 199 was also isolated as a trifluoro acetate salt as a result of C18 reverse phase chromatography. This salt can be converted into the corresponding free base form by standard extractive acid-base chemistry. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
61% | With potassium hydroxide; In tetrahydrofuran; at 20℃; for 1h;Inert atmosphere; | 2?-[3 -benzyloxy-( 1,1 ?:4?, 1 ?-terphenyl)]carbaldeyde (201 mg, 0.552 mmol) and diethyl(carbamoylmethyl)phosphonate (108 mg, 0.55 mmol) were dissolved in dry THF (7 mL), and added slowly to a vigorously stirred suspension of powdered potassium hydroxide (62 mg, 1.10 mmol) in THF (2 mL). The reaction was stirred at ambienttemperature for 1 h, under an argon atmosphere, monitoring by TLC (1:1 dichloromethane /pentane). The THF was removed under reduced pressure, and the residue taken up in water and extracted with dichloromethane (3x). The combined organic extracts were washed with brine (lx) then dried and concentrated. Recrystallisation from ethyl acetate/pentane afforded 2?-[3-benzyloxy-(1,1 ?:4?,1 ?-terphenyl)]acrylamide (137 mg, 61%) as pale yellow crystals; mp 175-176 C. ?H NMR(400 MHz, DMSO-d6) oe 7.95 (d, 1H, J=2.0 Hz); 7.78-7.22 (m, 3H); 7.55-7.3 1 (m, 12H);7.17-7.07 (m, 2H); 6.99 (m, 1H); 6.92 (m, 1H); 6.79 (d,J=15.8 Hz, 1H); 5.16 (s, 2H). ?3CNMR (125 MHz, DMSO-d6) oe 166.5, 158.3, 140.8, 140.7, 139.8, 139.4, 137.5, 137.0,133.2, 130.9, 129.5, 129.1, 128.5, 127.9, 127.8, 127.8, 127.6, 126.8, 124.5, 123.8, 122.2,115.9, 114.0, 69.4. ElMS: m/z 405 [M]. HRMS calcd for C28H23N02 405.1723, found405.1714. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With potassium hydroxide; In tetrahydrofuran; at 20℃; for 1h; | 3-Nitro-[ 1,1 ?:4?, 1 ?-terphenyl]-2-carbaldehyde (17) (2.35 g, 7.77 mmol) and diethyl(carbamoylmethyl)phosphonate (18) (1.51 g, 7.75 mmol) were dissolved in dryTHF (100 mL), and added slowly to a vigorously stirred suspension of powdered potassium hydroxide (0.86 g, 15.40 mmol). Following stirring for 1 h at rt, the material was precipitated from the reaction mixture by addition of water and diethyl ether to give (E)-3-(3-nitro-[i,i?:4?,i?-terphenyl]-2?-yl)acrylamide (19) (1.8 g, 82%) as a pale lemon solid. A small portion was purified by chromatography (DCVC) eluting with a gradientof ethyl acetate in DCM (0 - 20% ethyl acetate) for characterisation to give (E)-3-(3- nitro-[i,i?:4?,i?-terphenyl]-2?-yl)acrylamide (19) as a colourless solid; mp 206 - 210C. ?H NMR (400 MHz, DMSO-d6) oe 8.35 - 8.28 (m, iH), 8.18 - 8.15 (m, iH), 8.02- 7.98 (m, 1H), 7.85 - 7.76 (m, 5H), 7.56 - 7.41 (m, 4H), 7.49 (br s, 1H), 7.33 (d, 1H, J 15.7Hz), 7.15 (br s, 1H), 6.78 (d, 1H, J 15.7 Hz). ?3C NMR (100 MHz, DMSO-d6) oe 166.2,147.8, 140.9, 140.6, 139.1, 138.3, 136.5, 136.2, 133.4, 131.1, 130.0, 129.0, 128.0, 127.8,126.8, 125.0, 124.8, 123.8, 122.5. ElMS: m/zFound: M 344.1153, C21H16N203 requires344.1155. ElMS: m/z 344 (M, 37%), 326 (50), 252 (100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
36% | With potassium hydroxide; In tetrahydrofuran; at 20℃; for 1h;Inert atmosphere; | 3,5-Dimethoxy-[1,1?:4?,1?-terphenyl]-2?-carbaldehyde (20) (6.1 g, 19.1 mmol) and diethyl(carbamoylmethyl)phosphonate (18) (3.7 g, 19.1 mmol) were dissolved in dry THF (180mL), and added slowly to a vigorously stirred suspension of powdered KOH (2.1 g, 38.2mmol) in THF (70 mL). The reaction was stirred at rt for 1 h under an argon atmosphere.Analysis by TLC (1:2 DCM:PE) indicated the carbaldehyde had been consumed. The THF was removed under reduced pressure, and the residue taken up in water and extracted with DCM (x3). The combined organic extracts were washed with brine (xl) then dried (MgSO4) and concentrated to 50 mL. The solution was filtered through ashort column of silica eluting with DCM to afford (E/Z)-3-(3,5-dimethoxy-[1,1?:4?,1?- terphenyl]-2?-yl)acrylamide (21) (2.5 g, 36%) as an orange foam. ?H NMR (200 MHz, CDC13) oe 7.85 (d, 1H, J 1.7 Hz); 7.78 - 7.56 (m, 4H); 7.53 - 7.32 (m, 4H); 6.54 - 6.38 (m, 4H); 5.70 (brs, 2H); 3.81 (s, 6H). ?3C NMR (50 MHz, CDC13) oe 167.9, 160.8, 141.8, 141.7, 141.4, 140.9, 140.5, 133.4, 130.9, 129.1, 128.4, 127.9, 127.3, 125.7, 121.5, 108.3,100.1, 55.7. ElMS: m/zFound: M 359.1504, C23H2,03N requires 359.1516. ElMS: m/z359 (M, 3%). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
19% | With sodium hydroxide; In tetrahydrofuran; at 20℃; for 1h; | 3-Formyibiphenyi-4-yitritluoromethanesuitbnate (14) (3.80 g, 1 [.50 mn,o1) and diethyl (2-annno-2-oxocthyl)phosphonate (l8? (2 25 g 11 50 mmol) wete dssoked in tin TI-IF(100 mE), and added slowly to a vigorously stirred suspension of powdered sodium hydroxjde (0.92 g. 23.00 mmd). Following stirring br 1 h at it, the reaction mixture was partitioned between brine and ethyl acetate. A yellow by-product was removed by firation and the. layers separated. The organic layer was concentrated. and then purified. by chromatography (DCVC) eluting with a gradient of ethyl acetate in heptane (0 20%ethyl acetate) and then recrystallised from DCM and PP to give (E)-3-(3-amino-3- oxoprop- I -en- I -y-[ 1 -biphen> l]-4-yl ti ifluot omethanesultonate (2 3j as a heige solid (0.82 g, 19%); mp 130.6 132.3 C. H NMR (400 MHz, DMSO-4) 8 81)9 - 8.04 (m, 1H), 7.88 7.82 (m, [H), 7.79 - 7.73 (in. 2H), 7.65 - 7.41 (m, 6H, 7.33 (hr s, lIT), 6.93 (d, 1W 3J 16Hz). ?3CNMR(IOOMHZ,DMSO-d6)8 165.6, 146.4, 141.1, 138.0,130.0, 129.5, 129.1. 128.6, 128.4, 127.7, 127,1, 126.4, 122.8, 118.1 (q,J321 Hz). ElMS:nm/b Found: ivr 371.0420, C16H12F1NO42S requires 371.0434, ElMS: ith 371 (M?. 62%), 195 (100). 167 (100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
72% | With sodium hydroxide; In tetrahydrofuran; | Prepared according to the method used to generate compound 19; from 3,5-dinitro-[1,1? :4?, 1?-terphenyl]-2?-carbaldehyde (35) (1.75 g, 5.03 mmol), diethyl(carbamoylmethyl)phosphonate (18) (1.09 g, 5.59 mmol) and sodium hydroxide (0.50 g, 12.50 mmol) in THF (70 mL). The crude solid was recrystallised from acetonegive (E)-3-(3,5-dinitro-[1,1?:4?,1?-terphenyl]-2?-yl)acrylamide (36) as a pale tan solid (1.40 g, 72%); mp 221 -223 C. ?HNMR(400 MHz, DMSO-d6)oe 8.90(s, 1H), 8.58 (s,2H), 8.02 (s, 1H), 7.85 (d, 1H, J 8.0 Hz), 7.80 (d, 2H, J 7.6 Hz), 7.64 (d, 1H, J 8.0 Hz),7.56 -7.43 (m, 4H), 7.32 (d, 1H, 3Jtrafl,c 15.7 Hz), 7.16 (br s, 1H), 6.76 (d, 1H, 3Jtrafl,c 15.7 Hz). ?3C NMR (100 MHz, DMSO-d6) oe 166.1, 148.0, 142.4, 141.3, 138.9, 136.2, 135.9, 133.8, 131.3, 129.7, 129.1, 128.2, 127.8, 126.9, 126.1, 125.3, 117.6. ElMS: m/zFound:M 389.1000, C2,H,5N305 requires 389.1006. ElMS: m/z 389 (M, 42%), 252 (100). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
83% | With sodium hydroxide; In tetrahydrofuran; | Prepared actording to the method used to genetate compound 1 9 from (ci t-butvl (4-(3-totmyl-[1,lt-h,phenvi]-4-yl)pyudin-2-yl)eaihamate (31) (1 44 g 3 85 nimole) dietiwl(caib irnovlmtthy flphosphonatc (18) (0 7 S g, 3 8 mnio Ic) and sodium hych o ?cid&. (0 31 g7 70 inmol) in F[IF (40 rnL) (I?)-krt-But)l (4-(3-(3-amino-3-oxoprop-1-cn-1-yl)-[1 l_biphcn 11-4-yl)pyndm-2-yl)tarbamate (32) as prccipaated from the teaction iTlaturtupon addition. of water and diethyl ether as a colourless solid (1.32 g, 83%?); rnp 179.5182.2 C. ?H NMR (200 MHz, DMSO-d6) 6 9.95 (s, lH); 8.33 (in iH); 7.99 (d, IH, J1.6 Hz); 7.82-7.73 (in, 4Ff); 7.58-7.42 (in, 5H); 7.34 (d., IH,J 15.8 hz); 7.14 (hr s, lFfl;6.99 (dd, 1 H, J 1.5, 5.1 FIz); 6.77 (d, 1H, .1 15.7 hz); 1.46 (s, 9W). t NMR (50 MHz,DMSO-d) a 1663 1527, 1490, 1477, 1406, 1392 1387 1364, 133 1 1304 1290128.0, 127.7, 126.8, 124.6, 124.6, 119.2., 112.5, 79.7, 26.0. ElMS: ink Found: M1415.1873, C22H,503N, requires 415.1890. ElMS: n415 (Mt, 5%), 315 (58). 297 (64),271 (100). |
Tags: 5464-68-6 synthesis path| 5464-68-6 SDS| 5464-68-6 COA| 5464-68-6 purity| 5464-68-6 application| 5464-68-6 NMR| 5464-68-6 COA| 5464-68-6 structure
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P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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