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Chemical Structure| 54857-40-8 Chemical Structure| 54857-40-8

Structure of 54857-40-8

Chemical Structure| 54857-40-8

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Product Details of [ 54857-40-8 ]

CAS No. :54857-40-8
Formula : C10H23O5P
M.W : 254.26
SMILES Code : CC(C)(C)OP(OCCO)(OC(C)(C)C)=O

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Application In Synthesis of [ 54857-40-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 54857-40-8 ]

[ 54857-40-8 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 33494-80-3 ]
  • [ 540-51-2 ]
  • [ 54857-40-8 ]
YieldReaction ConditionsOperation in experiment
52.3% In N,N-dimethyl-formamide; at 80℃; (a) di-tert-butyl (2-hydroxyethyl) phosphate To a solution of di-tert-butyl hydrogen phosphate, potassium salt (15 g, 60.2 mmol, Aldrich) in DMF (100 ml_), 2-bromoethanol (7.52 g, 60.2 mmol, Aldrich) was added. The resulting mixture was heated at 80 °C overnight. The reaction was poured into water (250 ml.) and extracted with EtOAc (3 x 250 ml_). The organic layer was dried over Na2S04, filtered, concentrated under reduced pressure and the residue was purified by flash column chromatography (0-5percent MeOH/DCM) to afford desired di-tert-butyl (2-hydroxyethyl) phosphate as a colorless oil (8g, 52.3percent). *H NMR (400 MHz, DMSO-d6) delta: 4.83 - 4.77 (1H, m), 3.86 - 3.80 (2H, m), 3.58 - 3.51 (2H, m), 1.42 (18H, s)
 

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