[ CAS No. 5527-94-6 ] {[proInfo.proName]}

Name: 5527-94-6|4-Chloro-3-fluorotoluene|98%
Brand: Ambeed
SKU: A875388
Price: 7.0 USD
Availability: InStock
Rating: 94 (27 reviews)

,{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]}

HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

2D 3D

Structure of 5527-94-6 * Storage: {[proInfo.prStorage]}

Cart0 Add to My Favorites Add to My Favorites Bulk Inquiry Inquiry Add To Cart

Search after Editing

* Storage: {[proInfo.prStorage]}

For Research Only 110K+ Compounds Competitive Price 1-2 Day Shipping

Quality Control of [ 5527-94-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 5527-94-6 ]

SDS Specification

Alternatived Products of [ 5527-94-6 ]

Product Details of [ 5527-94-6 ]

CAS No. :	5527-94-6	MDL No. :	MFCD00143295
Formula :	C₇H₆ClF	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	MHXNHUSVBYUTJL-UHFFFAOYSA-N
M.W :	144.57	Pubchem ID :	2736590
Synonyms :

Calculated chemistry of [ 5527-94-6 ]

Physicochemical Properties

Num. heavy atoms :	9
Num. arom. heavy atoms :	6
Fraction Csp3 :	0.14
Num. rotatable bonds :	0
Num. H-bond acceptors :	1.0
Num. H-bond donors :	0.0
Molar Refractivity :	36.38
TPSA :	0.0 Å²

Pharmacokinetics

GI absorption :	Low
BBB permeant :	Yes
P-gp substrate :	No
CYP1A2 inhibitor :	Yes
CYP2C19 inhibitor :	No
CYP2C9 inhibitor :	No
CYP2D6 inhibitor :	No
CYP3A4 inhibitor :	No
Log Kp (skin permeation) :	-4.75 cm/s

Lipophilicity

Log Po/w (iLOGP) :	2.19
Log Po/w (XLOGP3) :	3.42
Log Po/w (WLOGP) :	3.21
Log Po/w (MLOGP) :	3.64
Log Po/w (SILICOS-IT) :	3.37
Consensus Log Po/w :	3.16

Druglikeness

Lipinski :	0.0
Ghose :	None
Veber :	0.0
Egan :	0.0
Muegge :	2.0
Bioavailability Score :	0.55

Water Solubility

Log S (ESOL) :	-3.38
Solubility :	0.0597 mg/ml ; 0.000413 mol/l
Class :	Soluble
Log S (Ali) :	-3.1
Solubility :	0.115 mg/ml ; 0.000794 mol/l
Class :	Soluble
Log S (SILICOS-IT) :	-3.66
Solubility :	0.0319 mg/ml ; 0.000221 mol/l
Class :	Soluble

Medicinal Chemistry

PAINS :	0.0 alert
Brenk :	0.0 alert
Leadlikeness :	1.0
Synthetic accessibility :	1.24

Safety of [ 5527-94-6 ]

Signal Word:	Danger	Class:	3
Precautionary Statements:	P261-P305+P351+P338	UN#:	1993
Hazard Statements:	H225-H315-H319-H335	Packing Group:	Ⅲ
GHS Pictogram:

Application In Synthesis of [ 5527-94-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5527-94-6 ]
Downstream synthetic route of [ 5527-94-6 ]

[ 5527-94-6 ] Synthesis Path-Upstream 1~6

1
[ 79-35-6 ]
[ 78-79-5 ]
[ 1513-25-3 ]
[ 5527-94-6 ]

Reference： [1] Journal of the American Chemical Society, 1968, vol. 90, p. 2049 - 2056

2
[ 79-35-6 ]
[ 78-79-5 ]
[ 1513-25-3 ]
[ 5527-94-6 ]

Reference： [1] Journal of the American Chemical Society, 1968, vol. 90, p. 2049 - 2056

3
[ 108-44-1 ]
[ 5527-94-6 ]

Reference： [1] Patent: CN107488098, 2017, A,

4
[ 352-70-5 ]
[ 5527-94-6 ]

Reference： [1] Patent: CN107488098, 2017, A,

5
[ 5527-94-6 ]
[ 64-19-7 ]
[ 403-17-8 ]

Yield	Reaction Conditions	Operation in experiment
94.2%	at 15℃; for 10 h;	Into 9931g of acetic acid, 2.7g of manganese acetate, 105g98percent sulfuric acid to a 20L autoclave, and then put into 99percent 3-fluoro-chlorotoluene 870g (5.96mol), stirred mixture was cooled to 15 , ozone slowly into 215g (total 10H); after completion of the reaction of nitrogen with the ozone photodissociation process; temperature and pressure recovery acetate, layers were separated and the product is recovered 988G, to give 3-fluoro-4-chlorobenzoic acid, 98.2percent pure, a yield of about 94.2 percent.

Reference： [1] Patent: CN107488098, 2017, A, . Location in patent: Paragraph 0031

6
[ 5527-94-6 ]
[ 118664-99-6 ]

Yield	Reaction Conditions	Operation in experiment
1.31 mg	at 0℃; for 0.5 h;	(Step 1) Synthesis of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 1-Chloro-2-fluoro-4-methylbenzene (1.00 g) was dissolved in TFA (10 mL). The solution was cooled to 0° C., and then, fuming nitric acid (5.0 mL) was added dropwise thereto. The mixture was stirred at 0° C. for 30 minutes, and then, the solution was added to an aqueous sodium bicarbonate solution and neutralized, followed by extraction with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to obtain 1.31 g of the title compound as a white solid.

Reference： [1] Patent: US2017/217970, 2017, A1, . Location in patent: Paragraph 0417

[ 5527-94-6 ] Synthesis Path-Downstream 1~21

1
[ 79-35-6 ]
[ 78-79-5 ]
[ 1513-25-3 ]
[ 5527-94-6 ]

Reference： [1]Journal of the American Chemical Society,1968,vol. 90,p. 2049 - 2056

2
[ 5527-94-6 ]
[ 68-12-2 ]
[ 1422510-55-1 ]

Yield	Reaction Conditions	Operation in experiment
7%		Intermediate 27 A. 3-Chloro-2-fluoro-6-methylbenzaldehyde: (Reference: E. J. Org. Chem 2005, 21 16 - 2123) To a solution of 2,2,6, 6-tetramethylpiperidine (0.642 mL, 3.80 mmol) in THF (15 mL) at -78 C was added rc-BuLi (2.162 mL, 3.46 mmol) dropwise. The resulting solution was stirred at -78 C for 1 h and added l-chloro-2- fluoro-4-methylbenzene (0.5 g, 3.46 mmol) dropwise. The solution was stirred for additional 0.5 h and then added DMF (0.536 mL, 6.92 mmol). The reaction was stirred at -78 C for 1.5 h and at ambient temperature for 12 h. The mixture was diluted with water and extracted with EtOAc (3x). The combined organic layer was washed with brine and concentrated. The residue was purified by silica gel chromatography to yield the desired product (43 mg, 7%).

Reference： [1]Patent: WO2013/22814,2013,A1 .Location in patent: Paragraph 00346

Yield	Reaction Conditions	Operation in experiment
		General procedure: To a four-necked flask was added 30 g (0.19 mol) of 3-chloroanisidine,30 g (1.67 mol) of water was added and the temperature was raised to 50 C,A solution of 36% HC1231 g (2.28 mol)After incubation for 0.5 h,The temperature was lowered to 0 C, and 30% NaN0244 was slowly added dropwise.Diazotization reaction,Upon completion of the addition,After 2h incubation,Remove the filter cake. 69.5 g (0.38 mol) of 48% HBF4 solution was added dropwise to the filtrate,To carry out condensation reaction,Insulation lh later.The solution was filtered,The solids were dried for dehydration.The dried fluoroborate,Slowly heated to 130 C for cracking reaction,Until no gas is produced.After the cracking of the solution for distillation,The 2,6-CFA fraction was collected to give 26 g of the title compound. Purity> 98.5%,The yield of 3 steps was 85% (from 2,3-dichloronitrobenzene to the final target compound,The overall yield was 69.4%).

4
[ 110-91-8 ]
[ 5527-94-6 ]
[ 122064-09-9 ]

Yield	Reaction Conditions	Operation in experiment
77%	With lithium hexamethyldisilazane; In tetrahydrofuran; at 90℃; for 14h;	General procedure: Morpholine lb (1 .0 mmol), LiHMDS (1 .0M in THF, 1 .5 mL) and fluorobenzene derivative (1 .5 mmol) was mixed and heated. Details regarding the individual reactions are given below.The structure of the compounds is provided in figure 2.; Synthesized from <strong>[5527-94-6]1-chloro-2-fluoro-4-methylbenzene</strong> according to the generalprocedure.After 14 hours at 90C the compound 3j was isolated in 77% yield as a clear oil. 1HNMR (CDCI3) oe ppm 7.23 (d, J = 8.0 Hz, 1 H), 6.84 (d, J = 2.0 Hz, 1 H), 6.82 - 6.77 (m,1H), 3.97-3.72 (m, 4H), 3.13-2.93 (m, 4H), 2.32 (5, 3H). 130 NMR (CDCI3) oe ppm148.6, 137.5, 130.3, 125.5, 124.5, 120.9, 67.1, 51.6, 21.1.

Reference： [1]Chemistry - A European Journal,2017,vol. 23,p. 846 - 851
[2]Patent: WO2017/137047,2017,A1 .Location in patent: Page/Page column 24; 26

5
[ 5527-94-6 ]
[ 118664-99-6 ]

Yield	Reaction Conditions	Operation in experiment
1.31 mg	With nitric acid; trifluoroacetic acid; at 0℃; for 0.5h;	(Step 1) Synthesis of 1-chloro-2-fluoro-4-methyl-5-nitrobenzene 1-Chloro-2-fluoro-4-methylbenzene (1.00 g) was dissolved in TFA (10 mL). The solution was cooled to 0 C., and then, fuming nitric acid (5.0 mL) was added dropwise thereto. The mixture was stirred at 0 C. for 30 minutes, and then, the solution was added to an aqueous sodium bicarbonate solution and neutralized, followed by extraction with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to obtain 1.31 g of the title compound as a white solid.
1.31 g	With nitric acid; trifluoroacetic acid; at 0℃; for 0.5h;	1-hloro-2-fluoro-4-methylbenzene (1.00 g) was dissolved in TFA (10 mL). The solution was cooled to 0C, and then, fuming nitric acid (5.0 mL) was added dropwise thereto. The mixture was stirred at 0C for 30 minutes, and then, the solution was added to an aqueous sodium bicarbonate solution and neutralized, followed by extraction with chloroform. The extract was dried over anhydrous sodium sulfate, and the solvent was distilled off under reduced pressure. The obtained residue was purified by silica gel chromatography (hexane/ethyl acetate) to obtain 1.31 g of the title compound as a white solid.

Reference： [1]Patent: US2017/217970,2017,A1 .Location in patent: Paragraph 0417
[2]Patent: EP3590516,2020,A1 .Location in patent: Paragraph 0361

6
[ 108-44-1 ]
[ 5527-94-6 ]

Reference： [1]Patent: CN107488098,2017,A

7
[ 5527-94-6 ]
[ 64-19-7 ]
[ 403-17-8 ]

Yield	Reaction Conditions	Operation in experiment
94.2%	With sulfuric acid; manganese(II) acetate; ozone; at 15℃; for 10h;	Into 9931g of acetic acid, 2.7g of manganese acetate, 105g98% sulfuric acid to a 20L autoclave, and then put into 99% 3-fluoro-chlorotoluene 870g (5.96mol), stirred mixture was cooled to 15 , ozone slowly into 215g (total 10H); after completion of the reaction of nitrogen with the ozone photodissociation process; temperature and pressure recovery acetate, layers were separated and the product is recovered 988G, to give 3-fluoro-4-chlorobenzoic acid, 98.2% pure, a yield of about 94.2 %.

Reference： [1]Patent: CN107488098,2017,A .Location in patent: Paragraph 0031

8
[ 352-70-5 ]
[ 5527-94-6 ]

Reference： [1]Patent: CN107488098,2017,A

9
2-methyl-4-fluoro-benzenesulfonic acid [ No CAS ]
[ 5527-94-6 ]
2-chloro-1-fluoro-3-methylbenzene [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
360 g; 148 g		Take 886g compound mixture of formula () and a compound of formula () (3.79mol) 10L into the reaction vessel, put into 8.5L 25% sulfuric acid, was heated to 110 deg.] C to reflux, no starting material the LC track, to stop the reaction, standing layer, Distillation of the organic phase was collected, and 360 g of the compound of the formula (VIII) was collected with purity of 99.0% (2.49 mol) at 156 C.; the purity of the compound 148 g of the formula (IX) was 98.9% (1.02 mol) at 164 C. The results were basically maintained with the analysis result. Consistent.

Reference： [1]Patent: CN107488098,2017,A .Location in patent: Paragraph 0027

10
[ 5527-94-6 ]
[ 64248-62-0 ]

Reference： [1]Patent: CN107488098,2017,A
[2]Patent: CN107488098,2017,A

11
[ 504-29-0 ]
[ 201230-82-2 ]
[ 5527-94-6 ]
[ 70354-44-8 ]

Reference： [1]European Journal of Organic Chemistry,2019,vol. 2019,p. 2172 - 2175

12
[ 695-34-1 ]
[ 201230-82-2 ]
[ 5527-94-6 ]
3,7-dimethyl-11H-pyrido[2,1-b]quinazolin-11-one [ No CAS ]

Reference： [1]European Journal of Organic Chemistry,2019,vol. 2019,p. 2172 - 2175

13
[ 201230-82-2 ]
[ 5527-94-6 ]
[ 95-55-6 ]
[ 3158-86-9 ]

Reference： [1]European Journal of Organic Chemistry,2019,vol. 2019,p. 2172 - 2175

14
4-chloro-4,5,5-trifluoro-1-methylcyclohex-1-ene [ No CAS ]
[ 5527-94-6 ]
[ 2927-34-6 ]

Yield	Reaction Conditions	Operation in experiment
8.5%; 83%	With N-benzyl-N,N,N-triethylammonium chloride; potassium hydroxide; In water; at 75 - 95℃; for 4.5h;	General procedure: A 50% aqueous KOH (392.0 g, 3.50 mol) was added to a mixture of cyclohexene 3a (170.5 g, 1.0 mol) and TEBAC (7.0 g)at 75-85 C (oil bath) with stirring over 90 min, then the mixture was stirred for 3 h at 85-95 C. Steam distillation of the resulting mixture gave a mixture of organic products, which was driedwith CaCl2. The dried mixture of product (110.8 g) contained 86.1% of 1,2-difluorobenzene (4a) and 9.2% of 2-chloro-1-fluorobenzene (8a). Distillation of this mixture afforded 94.91 g (83%) of 1,2-difluorobenzene (4a), b.p. 92-92.5 C, and 9.22 g (7%) of chlorofluorobenzene 8a, b.p. 137-138 C.

Reference： [1]Russian Chemical Bulletin,2020,vol. 69,p. 68 - 75
Izv. Akad. Nauk, Ser. Khim.,2020,vol. 1,p. 68 - 75,8

15
[ 4265-28-5 ]
[ 5527-94-6 ]
[ 2927-34-6 ]

Reference： [1]Russian Chemical Bulletin,2020,vol. 69,p. 68 - 75
Izv. Akad. Nauk, Ser. Khim.,2020,vol. 1,p. 68 - 75,8

16
[ 5527-94-6 ]
[ 388-83-0 ]

Yield	Reaction Conditions	Operation in experiment
Ca. 84%	With triphenylphosphine; sodium bromide; nickel dichloride; zinc; In N,N-dimethyl-formamide; at 60 - 62℃; for 2h;Inert atmosphere;	Add triphenylphosphine (132.3g, 0.5moL), sodium bromide (15.5g, 0.15moL), zinc powder (65.6g, 1moL), nickel chloride (6.7g, 0.05moL) to the reaction flask.Nitrogen was introduced to replace the air. Under room temperature and nitrogen protection, without stirring, 125mL DMF was added dropwise to the reaction flask for 5min.The material partially turns red, and then 200 mL of DMF is added, and the temperature is raised to 60 C. and stirring is continued for 1 h.A mixture of <strong>[5527-94-6]4-chloro-3-fluorotoluene</strong> (144.6g, 1moL) and DMF (144.6g dissolved in 50mL DMF) was added dropwise for about 2h.After the dropwise addition, the temperature was raised to 60 to 62 C, and the temperature was kept until the reaction was completed.After the reaction was completed, the temperature was lowered and filtered (diatomaceous earth assisted filtration). After the filtrate was concentrated under reduced pressure, 500 mL of toluene and 500 mL of water were added, allowed to stand, and the layers were separated.The organic layer was transferred into a reaction flask, cooled in an ice water bath, and hydrogen peroxide (68g, 0.6moL) was added dropwise to the organic layer for about 0.5h.After the dropwise addition, keep it at 40 for 1h, sample and analyze that triphenylphosphine is completely converted into triphenylphosphine oxide,Cooled to room temperature, filtered to remove triphenylphosphine oxide, the filter cake was washed with toluene (50mL), the filtrate was separated,Toluene was distilled off under reduced pressure, 80g of ethanol was added, and the temperature was raised until all the solids were dissolved, and the ice water was cooled to below 10 C.The solid was continuously washed out, filtered, and dried to obtain biphenyl. The white solid was 92.5g, the HPLC content was 99%, and the yield was about 84%.

Reference： [1]Patent: CN111100048,2020,A .Location in patent: Paragraph 0041-0044

17
[ 5527-94-6 ]
2,2'-difluoro-4,4'-dimethyl-5,5'-disulfonyl chloride-1,1'-biphenyl [ No CAS ]

Reference： [1]Patent: CN111100048,2020,A

18
[ 5527-94-6 ]
2,2'-difluoro-4,4'-dimethyl-5,5'-dimercapto-1,1'-biphenyl [ No CAS ]

Reference： [1]Patent: CN111100048,2020,A

19
[ 5527-94-6 ]
2,2'-difluoro-4,4'-dimethyl-5,5'-bis(2,2-difluoroethylthio)-1,1'-biphenyl [ No CAS ]

Reference： [1]Patent: CN111100048,2020,A

20
[ 5527-94-6 ]
(6,6′-difluoro-4,4′-dimethyl-[1,1′-biphenyl]-3,3′-diyl)bis((2,2,2-trifluoroethyl)sulfane) [ No CAS ]

Reference： [1]Patent: CN111100048,2020,A
[2]Patent: CN111100048,2020,A
[3]Patent: CN111100048,2020,A

21
[ 5527-94-6 ]
[ 403-17-8 ]

Reference： [1]Science China Chemistry,2021,vol. 64,p. 1487 - 1492

Same Skeleton Products

Related Products

Historical Records

Related Functional Groups of
[ 5527-94-6 ]

Fluorinated Building Blocks

[ 452-66-4 ]

4-Chloro-1-fluoro-2-methylbenzene

Similarity: 0.85

[ 2367-91-1 ]

2-Chloro-1,4-difluorobenzene

Similarity: 0.85

[ 1435-44-5 ]

1-Chloro-2,4-difluorobenzene

Similarity: 0.85

[ 348-59-4 ]

2,5-Dichlorofluorobenzene

Similarity: 0.85

[ 452-75-5 ]

4-Chloro-2-fluorotoluene

Similarity: 0.83

Aryls

[ 452-66-4 ]

4-Chloro-1-fluoro-2-methylbenzene

Similarity: 0.85

[ 2367-91-1 ]

2-Chloro-1,4-difluorobenzene

Similarity: 0.85

[ 1435-44-5 ]

1-Chloro-2,4-difluorobenzene

Similarity: 0.85

[ 348-59-4 ]

2,5-Dichlorofluorobenzene

Similarity: 0.85

[ 452-75-5 ]

4-Chloro-2-fluorotoluene

Similarity: 0.83

Chlorides

[ 452-66-4 ]

4-Chloro-1-fluoro-2-methylbenzene

Similarity: 0.85

[ 2367-91-1 ]

2-Chloro-1,4-difluorobenzene

Similarity: 0.85

[ 1435-44-5 ]

1-Chloro-2,4-difluorobenzene

Similarity: 0.85

[ 348-59-4 ]

2,5-Dichlorofluorobenzene

Similarity: 0.85

[ 452-75-5 ]

4-Chloro-2-fluorotoluene

Similarity: 0.83

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Purity	Size	Price	VIP Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
{[ item.p_purity ]}	{[ item.pr_size ]}	{[ getRatePrice(item.pr_usd, 1,1) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]}	{[ getRatePrice(item.pr_usd, 1,1) ]}	Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_usd,1,item.mem_rate) ]}	{[ item.pr_usastock ]}	Inquiry -	{[ item.pr_chinastock ]}	Inquiry -

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 5527-94-6 ] {[proInfo.proName]}

Quality Control of [ 5527-94-6 ]

Related Doc. of [ 5527-94-6 ]

Product Details of [ 5527-94-6 ]

Calculated chemistry of [ 5527-94-6 ]

Physicochemical Properties

Pharmacokinetics

Lipophilicity

Druglikeness

Water Solubility

Medicinal Chemistry

Safety of [ 5527-94-6 ]

Application In Synthesis of [ 5527-94-6 ]

[ 5527-94-6 ] Synthesis Path-Upstream 1~6

[ 5527-94-6 ] Synthesis Path-Downstream 1~21

Related Functional Groups of [ 5527-94-6 ]

Fluorinated Building Blocks

Aryls

Chlorides

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 5527-94-6 ]