Structure of Acesulfame potassium
CAS No.: 55589-62-3
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
Acesulfame potassium is a non-nutritive sweetener.
Synonyms: Acesulfame (potassium salt); E950; Acesulfame potassium salt
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| CAS No. : | 55589-62-3 |
| Formula : | C4H4KNO4S |
| M.W : | 201.24 |
| SMILES Code : | O=C1[N-]S(OC(C)=C1)(=O)=O.[K+] |
| Synonyms : |
Acesulfame (potassium salt); E950; Acesulfame potassium salt
|
| MDL No. : | MFCD00043833 |
| InChI Key : | WBZFUFAFFUEMEI-UHFFFAOYSA-M |
| Pubchem ID : | 11074431 |
| GHS Pictogram: |
|
| Signal Word: | Warning |
| Hazard Statements: | H302-H315-H319-H335 |
| Precautionary Statements: | P261-P305+P351+P338 |
| Description |
Acesulfame potassium constitutes an artificial sweetener. It has been observed that long-term exposure to Acesulfame potassium may influence cognitive functions, possibly through modifications in neuro-metabolic functions in mice[1].
|
Clinical Trial:
| NCT Number | Conditions | Phases | Recruitment | Completion Date | Locations |
| NCT00796354 | Constipation | Phase 3 | Completed | - | Czech Republic ... More >> Gastroenterologie s.r.o. Hradec Králové, Czech Republic, 500 02 EGK.s.r.o, Sanatorium sv. Anny Praha, Czech Republic, 130 00 Orlickoustecká Nemocnice a.s. Ústi Nad Orlicí, Czech Republic, 562 18 France Hôpital Hotel Dieu Clermont-Ferrand, France, 63058 Hôpital Archet II Nice, France, 06200 Hôpital Charles Nicolles Rouen, France, 76031 Germany Martin-Luther-Krankenhaus-Betriebs-GmbH Berlin, Germany, 14193 Gastroenterologische Gemeinschaftspraxis Münster, Germany, 48159 Facharztpraxis für Innere Medizin Wiesbaden, Germany, 65185 Italy Policlinico S. Orsola Malpighi Bologna, Italy, 40138 Università degli Studi di Genova Genova, Italy, 6 - 16132 Università degli Studi di Palermo Palermo, Italy, 129 - 90127 Università La Sapienza Roma, Italy, 00162 Poland Slaskie Centrum Osteoporozy Katowice, Poland, 40-084 Centrum Onkologii ul.Rentgena 5 Warsaw, Poland, 02-781 Prosen SMO Warszawa, Poland, 01-231 Katedra i Klinika Gastroenterologii i Hepatologii Wroclaw, Poland, 50-556 Sweden Sodra Alvsborgs Hospital (SAS) Borås, Sweden, SE-176-65 Karolinska University Hospital Solna Stockholm, Sweden, SE-171-76 United Kingdom St Marks Hospital Harrow, United Kingdom, HA1 3UJ John Radcliffe Hospital Oxford, United Kingdom, OX3 9DU Less << |
| NCT03663231 | Dry Mouth | Not Applicable | Recruiting | September 15, 2019 | United States, New York ... More >> University of Rochester Eastman Dental Center Recruiting Rochester, New York, United States, 14620 Contact: Christine Lung, MS 585-275-5087 Christine_Lung@urmc.rochester.edu Less << |
| NCT02890108 | Insulin Sensitivity | Not Applicable | Unknown | October 2016 | Chile ... More >> Institute of Nutrition and Tecnology of Food, University of Chile Recruiting Santiago, Metropolitan region, Chile Contact: Verónica Cornejo Espinoza, Director +56229781 410 vcornejo@inta.uchile.cl Contact: Sandra Hirsch Birn, Academic +56229781495 ext +56229781499 shirsch@inta.uchile.cl Principal Investigator: Romina A Goza Ferreira, Magister c Principal Investigator: Sandra Hirsch Birn, Magister Sub-Investigator: Gladys Barrera Acevedo, Magister Less << |
| NCT03380754 | Post Operative Nausea and Vomi... More >>ting Less << | Not Applicable | Recruiting | July 2019 | United States, Michigan ... More >> Henry Ford Hospital Recruiting Detroit, Michigan, United States, 48202 Contact: Allen A Kadado, MD 248-990-0410 akadado1@hfhs.org Less << |
| NCT03362697 | Urinary Tract Infection in Pre... More >>gnancy Less << | Not Applicable | Not yet recruiting | September 30, 2018 | Mexico ... More >> Hospital General Dr. Manuel Gea Gonzalez Mexico city, Tlalpan, Mexico, 14080 Less << |
| NCT01340690 | ADHD | Phase 3 | Terminated(The sample size of ... More >>the planned interims analysis was achieved) Less << | - | Germany ... More >> DRK Fachklinik für Kinder- und Jugendpsychiatrie, Psychotherapie, Psychosomatik Bad Neuenahr, Germany, D 53474 Charité - Universitätsmedizin Berlin, CVK Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters Berlin, Germany, D 13353 University Medicine Mainz Mainz, Germany, D 55131 Kinderzentrum Maulbronn gGmbH Maulbronn, Germany, D 75433 Johanniter - Zentrum für Kinder- und Jugendpsychiatrie Neuwied Neuwied, Germany, D 56564 Less << |
| NCT03039478 | Physiological Satiation Mechan... More >>isms Less << | Not Applicable | Completed | - | Switzerland ... More >> University Hospital Basel Basel, Switzerland, 4031 Less << |
| NCT02448667 | Glycogen Storage Disease Type ... More >>III Less << | Not Applicable | Recruiting | February 2018 | Denmark ... More >> Copenhagen Neuromuscular Center, department 3342, Rigshospitalet Recruiting Copenhagen, Region hovedstaden, Denmark, 2100 Contact: Astrid E Buch, MD +45 35 45 61 35 astrid.emilie.buch.02@regionh.dk Contact: Nicolai Preisler, MD +45 35 45 61 26 nicolai.preisler@regionh.dk Less << |
| NCT03200197 | Thirst | Not Applicable | Completed | - | - |
| NCT03707067 | Muscle Damage | Not Applicable | Recruiting | February 28, 2019 | United Kingdom ... More >> University of Bath Completed Bath, Somerset, United Kingdom, BA2 7AY St Marys University Recruiting London, United Kingdom, TW1 4SX Principal Investigator: Freddy Brown, MSc Sub-Investigator: Jessica Hill, PhD Less << |
| NCT00978900 | Healthy | Phase 1 | Completed | - | - |
| NCT03259685 | Gut Microbiota ... More >> Metabolic Syndrome Less << | Not Applicable | Recruiting | December 2020 | Canada ... More >> Laval University Recruiting Québec, Canada, G1V0A6 Contact: Marie-Claude Vohl 418-656-2131 ext 4676 marie-claude.vohl@ulaval.ca Less << |
| NCT03480971 | Mucositis Nep... More >>hrotoxicity Ototoxicity Less << | Phase 2 | Not yet recruiting | October 2019 | United States, Maryland ... More >> University Maryland School of Medicine Not yet recruiting Baltimore, Maryland, United States, 21201 Contact: Robert Malyapa, MD 410-328-6080 Principal Investigator: Robert Malyapa, MD Less << |
| NCT02877186 | Obesity Diabe... More >>tes Less << | Not Applicable | Unknown | - | - |
| NCT02891525 | Healthy | Not Applicable | Completed | - | - |
| NCT02545712 | - | Active, not recruiting | - | - | |
| NCT03543644 | Healthy Overw... More >>eight and Obesity Metabolic Syndrome PreDiabetes Diabetes Overweight Obesity Dysglycemia Cardiovascular Diseases Cardiovascular Risk Factor Hypertension Less << | Not Applicable | Recruiting | November 2020 | Canada, Ontario ... More >> St Michael's Hospital Recruiting Toronto, Ontario, Canada, M5C2T2 Contact: Maxine Seider, MSc, RD 4168677460 ext 8216 seiderm@smh.ca Principal Investigator: John Sievenpiper, MD, PhD, FRCPC Less << |
| NCT01200940 | Healthy Volunteers | Phase 1 Phase 2 | Recruiting | June 30, 2020 | United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov Less << |
| NCT03232008 | Artificial Sweetener Effects o... More >>n Blood Glucose and Appetite Appetitive Behavior Less << | Not Applicable | Recruiting | February 28, 2018 | United Kingdom ... More >> King's College London Recruiting London, United Kingdom, SE1 9NH Contact: Christopher P Corpe +44 (0) 20 7848 4269 christopher.corpe@kcl.ac.uk Less << |
Tags: 55589-62-3 synthesis path| 55589-62-3 SDS| 55589-62-3 COA| 55589-62-3 purity| 55589-62-3 application| 55589-62-3 NMR| 55589-62-3 COA| 55589-62-3 structure
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| Code | Phrase |
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| Code | Phrase |
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| P221 | Take any precaution to avoid mixing with combustibles |
| P222 | Do not allow contact with air. |
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| P230 | Keep wetted |
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| P265 | Wash skin thouroughly after handling. |
| P270 | Do not eat, drink or smoke when using this product. |
| P271 | Use only outdoors or in a well-ventilated area. |
| P272 | Contaminated work clothing should not be allowed out of the workplace. |
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| P281 | Use personal protective equipment as required. |
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| P283 | Wear fire/flame resistant/retardant clothing. |
| P284 | Wear respiratory protection. |
| P285 | In case of inadequate ventilation wear respiratory protection. |
| P231 + P232 | Handle under inert gas. Protect from moisture. |
| P235 + P410 | Keep cool. Protect from sunlight. |
Response | |
| Code | Phrase |
| P301 | IF SWALLOWED: |
| P304 | IF INHALED: |
| P305 | IF IN EYES: |
| P306 | IF ON CLOTHING: |
| P307 | IF exposed: |
| P308 | IF exposed or concerned: |
| P309 | IF exposed or if you feel unwell: |
| P310 | Immediately call a POISON CENTER or doctor/physician. |
| P311 | Call a POISON CENTER or doctor/physician. |
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| P322 | |
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| P336 | Thaw frosted parts with lukewarm water. Do not rub affected area. |
| P337 | If eye irritation persists: |
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| P340 | Remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P341 | If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
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| P350 | Gently wash with plenty of soap and water. |
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| P376 | Stop leak if safe to do so. Oxidising gases (section 2.4) 1 |
| P377 | Leaking gas fire: Do not extinguish, unless leak can be stopped safely. |
| P378 | |
| P380 | Evacuate area. |
| P381 | Eliminate all ignition sources if safe to do so. |
| P390 | Absorb spillage to prevent material damage. |
| P391 | Collect spillage. Hazardous to the aquatic environment |
| P301 + P310 | IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. |
| P301 + P312 | IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell. |
| P301 + P330 + P331 | IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. |
| P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
| P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
| P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
| P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
| P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
| P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
| P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
| P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
| P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
| P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
| P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
| P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
| P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
| P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
| P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
| P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
| P370 + P376 | In case of fire: Stop leak if safe to Do so. |
| P370 + P378 | In case of fire: |
| P370 + P380 | In case of fire: Evacuate area. |
| P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
| P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
| Code | Phrase |
| P401 | |
| P402 | Store in a dry place. |
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| P413 | |
| P420 | Store away from other materials. |
| P422 | |
| P402 + P404 | Store in a dry place. Store in a closed container. |
| P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
| P403 + P235 | Store in a well-ventilated place. Keep cool. |
| P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
| P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
| P411 + P235 | Keep cool. |
Disposal | |
| Code | Phrase |
| P501 | Dispose of contents/container to ... |
| P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
| Code | Phrase |
| H200 | Unstable explosive |
| H201 | Explosive; mass explosion hazard |
| H202 | Explosive; severe projection hazard |
| H203 | Explosive; fire, blast or projection hazard |
| H204 | Fire or projection hazard |
| H205 | May mass explode in fire |
| H220 | Extremely flammable gas |
| H221 | Flammable gas |
| H222 | Extremely flammable aerosol |
| H223 | Flammable aerosol |
| H224 | Extremely flammable liquid and vapour |
| H225 | Highly flammable liquid and vapour |
| H226 | Flammable liquid and vapour |
| H227 | Combustible liquid |
| H228 | Flammable solid |
| H229 | Pressurized container: may burst if heated |
| H230 | May react explosively even in the absence of air |
| H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
| H240 | Heating may cause an explosion |
| H241 | Heating may cause a fire or explosion |
| H242 | Heating may cause a fire |
| H250 | Catches fire spontaneously if exposed to air |
| H251 | Self-heating; may catch fire |
| H252 | Self-heating in large quantities; may catch fire |
| H260 | In contact with water releases flammable gases which may ignite spontaneously |
| H261 | In contact with water releases flammable gas |
| H270 | May cause or intensify fire; oxidizer |
| H271 | May cause fire or explosion; strong oxidizer |
| H272 | May intensify fire; oxidizer |
| H280 | Contains gas under pressure; may explode if heated |
| H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
| H290 | May be corrosive to metals |
Health hazards | |
| Code | Phrase |
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| H301 | Toxic if swallowed |
| H302 | Harmful if swallowed |
| H303 | May be harmful if swallowed |
| H304 | May be fatal if swallowed and enters airways |
| H305 | May be harmful if swallowed and enters airways |
| H310 | Fatal in contact with skin |
| H311 | Toxic in contact with skin |
| H312 | Harmful in contact with skin |
| H313 | May be harmful in contact with skin |
| H314 | Causes severe skin burns and eye damage |
| H315 | Causes skin irritation |
| H316 | Causes mild skin irritation |
| H317 | May cause an allergic skin reaction |
| H318 | Causes serious eye damage |
| H319 | Causes serious eye irritation |
| H320 | Causes eye irritation |
| H330 | Fatal if inhaled |
| H331 | Toxic if inhaled |
| H332 | Harmful if inhaled |
| H333 | May be harmful if inhaled |
| H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
| H335 | May cause respiratory irritation |
| H336 | May cause drowsiness or dizziness |
| H340 | May cause genetic defects |
| H341 | Suspected of causing genetic defects |
| H350 | May cause cancer |
| H351 | Suspected of causing cancer |
| H360 | May damage fertility or the unborn child |
| H361 | Suspected of damaging fertility or the unborn child |
| H361d | Suspected of damaging the unborn child |
| H362 | May cause harm to breast-fed children |
| H370 | Causes damage to organs |
| H371 | May cause damage to organs |
| H372 | Causes damage to organs through prolonged or repeated exposure |
| H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
| Code | Phrase |
| H400 | Very toxic to aquatic life |
| H401 | Toxic to aquatic life |
| H402 | Harmful to aquatic life |
| H410 | Very toxic to aquatic life with long-lasting effects |
| H411 | Toxic to aquatic life with long-lasting effects |
| H412 | Harmful to aquatic life with long-lasting effects |
| H413 | May cause long-lasting harmful effects to aquatic life |
| H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
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