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Chemical Structure| 55589-62-3 Chemical Structure| 55589-62-3

Structure of Acesulfame potassium
CAS No.: 55589-62-3

Chemical Structure| 55589-62-3

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Acesulfame potassium is a non-nutritive sweetener.

Synonyms: Acesulfame (potassium salt); E950; Acesulfame potassium salt

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Product Details of Acesulfame potassium

CAS No. :55589-62-3
Formula : C4H4KNO4S
M.W : 201.24
SMILES Code : O=C1[N-]S(OC(C)=C1)(=O)=O.[K+]
Synonyms :
Acesulfame (potassium salt); E950; Acesulfame potassium salt
MDL No. :MFCD00043833
InChI Key :WBZFUFAFFUEMEI-UHFFFAOYSA-M
Pubchem ID :11074431

Safety of Acesulfame potassium

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

Description
Acesulfame potassium constitutes an artificial sweetener. It has been observed that long-term exposure to Acesulfame potassium may influence cognitive functions, possibly through modifications in neuro-metabolic functions in mice[1].

Clinical Trial:

NCT Number Conditions Phases Recruitment Completion Date Locations
NCT00796354 Constipation Phase 3 Completed - Czech Republic ... More >> Gastroenterologie s.r.o. Hradec Králové, Czech Republic, 500 02 EGK.s.r.o, Sanatorium sv. Anny Praha, Czech Republic, 130 00 Orlickoustecká Nemocnice a.s. Ústi Nad Orlicí, Czech Republic, 562 18 France Hôpital Hotel Dieu Clermont-Ferrand, France, 63058 Hôpital Archet II Nice, France, 06200 Hôpital Charles Nicolles Rouen, France, 76031 Germany Martin-Luther-Krankenhaus-Betriebs-GmbH Berlin, Germany, 14193 Gastroenterologische Gemeinschaftspraxis Münster, Germany, 48159 Facharztpraxis für Innere Medizin Wiesbaden, Germany, 65185 Italy Policlinico S. Orsola Malpighi Bologna, Italy, 40138 Università degli Studi di Genova Genova, Italy, 6 - 16132 Università degli Studi di Palermo Palermo, Italy, 129 - 90127 Università La Sapienza Roma, Italy, 00162 Poland Slaskie Centrum Osteoporozy Katowice, Poland, 40-084 Centrum Onkologii ul.Rentgena 5 Warsaw, Poland, 02-781 Prosen SMO Warszawa, Poland, 01-231 Katedra i Klinika Gastroenterologii i Hepatologii Wroclaw, Poland, 50-556 Sweden Sodra Alvsborgs Hospital (SAS) Borås, Sweden, SE-176-65 Karolinska University Hospital Solna Stockholm, Sweden, SE-171-76 United Kingdom St Marks Hospital Harrow, United Kingdom, HA1 3UJ John Radcliffe Hospital Oxford, United Kingdom, OX3 9DU Less <<
NCT03663231 Dry Mouth Not Applicable Recruiting September 15, 2019 United States, New York ... More >> University of Rochester Eastman Dental Center Recruiting Rochester, New York, United States, 14620 Contact: Christine Lung, MS    585-275-5087    Christine_Lung@urmc.rochester.edu Less <<
NCT02890108 Insulin Sensitivity Not Applicable Unknown October 2016 Chile ... More >> Institute of Nutrition and Tecnology of Food, University of Chile Recruiting Santiago, Metropolitan region, Chile Contact: Verónica Cornejo Espinoza, Director    +56229781 410    vcornejo@inta.uchile.cl    Contact: Sandra Hirsch Birn, Academic    +56229781495 ext +56229781499    shirsch@inta.uchile.cl    Principal Investigator: Romina A Goza Ferreira, Magister c          Principal Investigator: Sandra Hirsch Birn, Magister          Sub-Investigator: Gladys Barrera Acevedo, Magister Less <<
NCT03380754 Post Operative Nausea and Vomi... More >>ting Less << Not Applicable Recruiting July 2019 United States, Michigan ... More >> Henry Ford Hospital Recruiting Detroit, Michigan, United States, 48202 Contact: Allen A Kadado, MD    248-990-0410    akadado1@hfhs.org Less <<
NCT03362697 Urinary Tract Infection in Pre... More >>gnancy Less << Not Applicable Not yet recruiting September 30, 2018 Mexico ... More >> Hospital General Dr. Manuel Gea Gonzalez Mexico city, Tlalpan, Mexico, 14080 Less <<
NCT01340690 ADHD Phase 3 Terminated(The sample size of ... More >>the planned interims analysis was achieved) Less << - Germany ... More >> DRK Fachklinik für Kinder- und Jugendpsychiatrie, Psychotherapie, Psychosomatik Bad Neuenahr, Germany, D 53474 Charité - Universitätsmedizin Berlin, CVK Klinik für Psychiatrie, Psychosomatik und Psychotherapie des Kindes- und Jugendalters Berlin, Germany, D 13353 University Medicine Mainz Mainz, Germany, D 55131 Kinderzentrum Maulbronn gGmbH Maulbronn, Germany, D 75433 Johanniter - Zentrum für Kinder- und Jugendpsychiatrie Neuwied Neuwied, Germany, D 56564 Less <<
NCT03039478 Physiological Satiation Mechan... More >>isms Less << Not Applicable Completed - Switzerland ... More >> University Hospital Basel Basel, Switzerland, 4031 Less <<
NCT02448667 Glycogen Storage Disease Type ... More >>III Less << Not Applicable Recruiting February 2018 Denmark ... More >> Copenhagen Neuromuscular Center, department 3342, Rigshospitalet Recruiting Copenhagen, Region hovedstaden, Denmark, 2100 Contact: Astrid E Buch, MD    +45 35 45 61 35    astrid.emilie.buch.02@regionh.dk    Contact: Nicolai Preisler, MD    +45 35 45 61 26    nicolai.preisler@regionh.dk Less <<
NCT03200197 Thirst Not Applicable Completed - -
NCT03707067 Muscle Damage Not Applicable Recruiting February 28, 2019 United Kingdom ... More >> University of Bath Completed Bath, Somerset, United Kingdom, BA2 7AY St Marys University Recruiting London, United Kingdom, TW1 4SX Principal Investigator: Freddy Brown, MSc          Sub-Investigator: Jessica Hill, PhD Less <<
NCT00978900 Healthy Phase 1 Completed - -
NCT03259685 Gut Microbiota ... More >> Metabolic Syndrome Less << Not Applicable Recruiting December 2020 Canada ... More >> Laval University Recruiting Québec, Canada, G1V0A6 Contact: Marie-Claude Vohl    418-656-2131 ext 4676    marie-claude.vohl@ulaval.ca Less <<
NCT03480971 Mucositis Nep... More >>hrotoxicity Ototoxicity Less << Phase 2 Not yet recruiting October 2019 United States, Maryland ... More >> University Maryland School of Medicine Not yet recruiting Baltimore, Maryland, United States, 21201 Contact: Robert Malyapa, MD    410-328-6080       Principal Investigator: Robert Malyapa, MD Less <<
NCT02877186 Obesity Diabe... More >>tes Less << Not Applicable Unknown - -
NCT02891525 Healthy Not Applicable Completed - -
NCT02545712 - Active, not recruiting - -
NCT03543644 Healthy Overw... More >>eight and Obesity Metabolic Syndrome PreDiabetes Diabetes Overweight Obesity Dysglycemia Cardiovascular Diseases Cardiovascular Risk Factor Hypertension Less << Not Applicable Recruiting November 2020 Canada, Ontario ... More >> St Michael's Hospital Recruiting Toronto, Ontario, Canada, M5C2T2 Contact: Maxine Seider, MSc, RD    4168677460 ext 8216    seiderm@smh.ca    Principal Investigator: John Sievenpiper, MD, PhD, FRCPC Less <<
NCT01200940 Healthy Volunteers Phase 1 Phase 2 Recruiting June 30, 2020 United States, Maryland ... More >> National Institutes of Health Clinical Center, 9000 Rockville Pike Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR)    800-411-1222 ext TTY8664111010    prpl@cc.nih.gov Less <<
NCT03232008 Artificial Sweetener Effects o... More >>n Blood Glucose and Appetite Appetitive Behavior Less << Not Applicable Recruiting February 28, 2018 United Kingdom ... More >> King's College London Recruiting London, United Kingdom, SE1 9NH Contact: Christopher P Corpe    +44 (0) 20 7848 4269    christopher.corpe@kcl.ac.uk Less <<

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.97mL

0.99mL

0.50mL

24.85mL

4.97mL

2.48mL

49.69mL

9.94mL

4.97mL

Dissolving Methods
Please choose the appropriate dissolution scheme according to your animal administration guide.For the following dissolution schemes, clear stock solution should be prepared according to in vitro experiments, and then cosolvent should be added in turn:

in order to ensure the reliability of the experimental results, the clarified stock solution can be properly preserved according to the storage conditions; The working fluid for in vivo experiment is recommended to be prepared now and used on the same day;

The percentage shown in front of the following solvent refers to the volume ratio of the solvent in the final solution; If precipitation or precipitation occurs in the preparation process, it can be assisted by heating and/or ultrasound.
Protocol 1
Protocol 2

References

 

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