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Chemical Structure| 56317-21-6 Chemical Structure| 56317-21-6

Structure of Moracin M
CAS No.: 56317-21-6

Chemical Structure| 56317-21-6

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Moracin M is a phytoalexin and inhibits PDE4D2, PDE4B2, PDE5A1, and PDE9A2 with the IC(50) values of 2.9, 4.5, > 40, and > 100 μM, respectively.

Synonyms: Moracin M

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Product Details of Moracin M

CAS No. :56317-21-6
Formula : C14H10O4
M.W : 242.23
SMILES Code : OC1=CC(C2=CC3=CC=C(O)C=C3O2)=CC(O)=C1
Synonyms :
Moracin M
MDL No. :MFCD17166969
InChI Key :LHPRYOJTASOZGJ-UHFFFAOYSA-N
Pubchem ID :185848

Safety of Moracin M

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Isoform Comparison

Biological Activity

In Vitro:

Cell Line
Concentration Treated Time Description References
HepG2 cells 1 μM 24 hours Evaluate PPARγ protein expression, results showed Moracin M had a tendency to increase PPARγ protein level but without statistical significance J Agric Food Chem. 2025 Jun 4;73(22):13960-13972
HeLa GLUT4-myc-GFP cells 10 μM 10 minutes Evaluate GLUT4 translocation, results showed Moracin M slightly increased GLUT4-GFP signal change values, but below the 3% threshold for positive results J Agric Food Chem. 2025 Jun 4;73(22):13960-13972
HEK-293 cells 1 μM 18 hours Evaluate PPARγ agonistic activity, results showed Moracin M had very low agonism to PPARγ J Agric Food Chem. 2025 Jun 4;73(22):13960-13972
Human recombinant DPP4 enzyme 100 μM 30 minutes Evaluate the inhibitory activity of Moracin M on DPP4, showing moderate inhibitory effect Front Pharmacol. 2024 Feb 23;15:1338333
mushroom tyrosinase 8.00 ± 0.22 µM 20 minutes Evaluate the inhibitory activity of Moracin M on mushroom tyrosinase, showing significant inhibition with an IC50 value of 8.00 ± 0.22 µM. Molecules. 2016 Sep 2;21(9):1130
MRSA 7112 16, 32, 64 µg/mL 24 hours Evaluate the inhibitory effect of Moracin M on AI-2 production in MRSA 7112, showing significant inhibition at concentrations of 16, 32, and 64 µg/mL. Microorganisms. 2025 Jan 27;13(2):287
Vibrio harveyi MM30 16, 32, 64 µg/mL 24 hours Evaluate the inhibitory activity of Moracin M on AI-2-mediated quorum sensing, showing significant inhibition of AI-2 production at concentrations of 16, 32, and 64 µg/mL. Microorganisms. 2025 Jan 27;13(2):287
C2C12 cells 25 µM 6 days Evaluate the effect of Moracin M on skeletal muscle cell proliferation, results showed that Moracin M significantly increased the proliferation of C2C12 cells Sci Rep. 2023 Nov 23;13(1):20570

In Vivo:

Species
Animal Model
Administration Dosage Frequency Description References
Chicken embryos HET-CAM model Injection 40 μM 60 and 120 minutes Evaluate hypoglycemic effect, results showed Moracin M significantly reduced blood glucose levels by 7.33% after 120 min J Agric Food Chem. 2025 Jun 4;73(22):13960-13972

Protocol

Bio Calculators
Preparing Stock Solutions 1mg 5mg 10mg

1 mM

5 mM

10 mM

4.13mL

0.83mL

0.41mL

20.64mL

4.13mL

2.06mL

41.28mL

8.26mL

4.13mL

References

 

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