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[ CAS No. 5699-41-2 ] {[proInfo.proName]}

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Chemical Structure| 5699-41-2
Chemical Structure| 5699-41-2
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Product Details of [ 5699-41-2 ]

CAS No. :5699-41-2 MDL No. :MFCD10024834
Formula : C6H14N2O Boiling Point : -
Linear Structure Formula :- InChI Key :-
M.W : 130.19 Pubchem ID :-
Synonyms :
NAP

Safety of [ 5699-41-2 ]

Signal Word:Danger Class:8
Precautionary Statements:P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P405-P501 UN#:2735
Hazard Statements:H314 Packing Group:
GHS Pictogram:

Application In Synthesis of [ 5699-41-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 5699-41-2 ]

[ 5699-41-2 ] Synthesis Path-Downstream   1~50

  • 1
  • [ 101938-77-6 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
With ethanol; hydrazine hydrate
  • 2
  • [ 5699-41-2 ]
  • [ 107-13-1 ]
  • [ 64144-59-8 ]
YieldReaction ConditionsOperation in experiment
With ethanol
  • 3
  • [ 5699-41-2 ]
  • [ 6719-83-1 ]
  • [ 32483-93-5 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane
  • 4
  • [ 108-24-7 ]
  • [ 110-60-1 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
In water
  • 5
  • [ 5699-41-2 ]
  • [ 76-83-5 ]
  • [ 36560-53-9 ]
YieldReaction ConditionsOperation in experiment
With triethylamine In chloroform
  • 6
  • [ 5699-41-2 ]
  • [ 100-52-7 ]
  • [ 25978-58-9 ]
YieldReaction ConditionsOperation in experiment
In methanol
  • 8
  • [ 5699-41-2 ]
  • [ 590-86-3 ]
  • [ 25978-60-3 ]
YieldReaction ConditionsOperation in experiment
With hydrogen In methanol
  • 9
  • [ 5699-41-2 ]
  • [ 74-88-4 ]
  • N-Trimethylammonium-N'-acetyl-1,4-diaminobutan [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium hydroxide In ethanol
  • 11
  • [ 5699-41-2 ]
  • [ 65564-05-8 ]
  • [ 86550-23-4 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane
  • 12
  • [ 5699-41-2 ]
  • [ 107-08-4 ]
  • N4-Acetyl-N1-propylpurescine hydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
82% With hydrogenchloride; triethylamine 1) DMF, a) 10 h, 21 deg C, b) 5 h, 60 deg C, 2) H2O;
  • 13
  • [ 5699-41-2 ]
  • [ 6630-33-7 ]
  • [ 128651-78-5 ]
YieldReaction ConditionsOperation in experiment
96%
  • 15
  • [ 5699-41-2 ]
  • [ 157363-85-4 ]
  • N-[4-((2S,3R,4R,5R)-3,4-Bis-benzyloxy-5-hydroxy-2-hydroxymethyl-piperidin-1-yl)-butyl]-acetamide [ No CAS ]
  • N-[4-((3R,4R,5R,6R)-4,5-Bis-benzyloxy-3,6-dihydroxy-azepan-1-yl)-butyl]-acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
1: 32% 2: 48% In chloroform for 6h; Heating;
  • 16
  • [ 141-78-6 ]
  • [ 110-60-1 ]
  • [ 5699-41-2 ]
  • [ 3073-57-2 ]
YieldReaction ConditionsOperation in experiment
1: 65% 2: 28% at 100℃; for 24h;
  • 18
  • [ 5699-41-2 ]
  • [ 100805-10-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 14.5 g / H2 / PtO2 / acetic acid; ethanol / 30 °C 2: 16.5 g / diethyl ether
  • 19
  • [ 5699-41-2 ]
  • [ 100805-12-7 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: 14.5 g / H2 / PtO2 / acetic acid; ethanol / 30 °C 2: 16.5 g / diethyl ether 3: 14 g / 22percent H2O2, Na2WO4*2H2O, Trilon B / H2O
  • 20
  • [ 5699-41-2 ]
  • N8-acetylspermidine dihydrochloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: CH2Cl2 2: NaBH4 3: 70 percent / H2
  • 21
  • [ 5699-41-2 ]
  • [ 86563-01-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: CH2Cl2 2: NaBH4
  • 22
  • [ 5699-41-2 ]
  • [ 128672-15-1 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: 96 percent 2: 30 percent / pyridine / Heating
  • 23
  • [ 5699-41-2 ]
  • [ 36560-54-0 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: Et3N / CHCl3 2: (i) NaOH, nPrOH, (ii) /BRN= 972409/, Et3N, benzene
  • 24
  • [ 5699-41-2 ]
  • [ 126617-68-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: Et3N / CHCl3 2: (i) NaOH, nPrOH, (ii) /BRN= 972409/, Et3N, benzene 3: AcOH
  • 25
  • [ 5699-41-2 ]
  • [ 36560-56-2 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 4 steps 1: Et3N / CHCl3 2: (i) NaOH, nPrOH, (ii) /BRN= 972409/, Et3N, benzene 3: AcOH 4: (i) NaOH, EtOH, CH2Cl2, (ii) /BRN= 1882498/, Et3N
  • 26
  • [ 5699-41-2 ]
  • [ 36560-57-3 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 5 steps 1: Et3N / CHCl3 2: (i) NaOH, nPrOH, (ii) /BRN= 972409/, Et3N, benzene 3: AcOH 4: (i) NaOH, EtOH, CH2Cl2, (ii) /BRN= 1882498/, Et3N 5: tetrahydrofuran
  • 27
  • [ 5699-41-2 ]
  • {2-[(4-Acetylamino-butylamino)-phenoxy-phosphoryloxy]-ethyl}-trimethyl-ammonium; chloride [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: CH2Cl2
  • 28
  • [ 5699-41-2 ]
  • C11H26N3O4P [ No CAS ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: CH2Cl2 3: aq. Ba(OH)2
  • 29
  • [ 5699-41-2 ]
  • [ 180156-28-9 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: methanol 2: (i) MeCN, (ii) aq. NaOH
  • 30
  • [ 5699-41-2 ]
  • [ 169499-08-5 ]
  • [ 169499-54-1 ]
YieldReaction ConditionsOperation in experiment
63% 30 N-acetyl-N'-{N-[(2S,3S)-3-trans-ethoxycarbonyloxirane-2-carbonyl]-L-phenylalanyl}-1,4-diaminobutane N-[(2S,3S)-3-trans-ethoxycarbonyloxirane-2-carbonyl]-L-phenylalanine (1.22 g) and N-acetyl-1,4-diaminobutane (0.47 g) were condensed together in the same manner as in Example 20 to yield the title compound (compound 28; 0.96 g) as a white powder (yield 63%). Elemental analysis (for C21 H29 N3 O6*0.3 H2 O): Calculated: C; 59.37, H; 7.02, N; 9.89 Found: C; 59.37, H; 6.89, N; 9.79 1 H NMR δ ppm (DMSO-d6) 1.22 (3H, t, J=7.0 Hz), 1.32 (4H, m), 1.78 (3H, s), 2.79 (1H, dd, J=9.5, 14.0 Hz), 2.92-3.10 (5H, m), 3.42 (1H, d, J=2.0 Hz), 3.64 (1H, d, J=2.0 Hz), 4.17 (2H, m), 4.50 (1H, m), 7.16-7.31 (5H, m), 7.79 (1H, br t, J=5.5 Hz), 8.11 (1H, br t, J=5.5 Hz), 8.66 (1H, br d, J=8.5 Hz)
  • 31
  • [ 125338-17-2 ]
  • [ 5699-41-2 ]
  • 3,4-dihydro-6-[N-(4-acetylaminobutyl)sulfamoyl]-3-(2-chlorophenyl)-2-methyl-4-oxothieno[2,3-d]pyrimidine [ No CAS ]
YieldReaction ConditionsOperation in experiment
With triethylamine In dichloromethane 4 3,4-Dihydro-6-[N-(4-acetylaminobutyl)sulfamoyl]-3-(2-chlorophenyl)-2-methyl-4-oxothieno[2,3-d]pyrimidine EXAMPLE 4 3,4-Dihydro-6-[N-(4-acetylaminobutyl)sulfamoyl]-3-(2-chlorophenyl)-2-methyl-4-oxothieno[2,3-d]pyrimidine To 8.0 g of 3,4-dihydro-3-(2-chlorophenyl)-6-chlorosulfonyl-2-methyl-4-oxothieno[2,3-d]pyrimidine were added 150 ml of dichloromethane, 3.3 g of 4-acetylaminobutylamine and 5.9 ml of triethylamine, and the mixture was stirred at room temperature for 3 hours. After the reaction mixture was washed with water, the concentrated residue was purified by means of silica gel chromatography to obtain 5.71 g of oily substance, which was crystallized from ethyl acetate-hexane to afford 4.44 g of the title compound, m.p. 203°-206° C. (decomposition).
  • 32
  • [ 13325-10-5 ]
  • [ 75-05-8 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
33% With sulfuric acid; acetic acid at 20℃; for 5h;
  • 33
  • [ 5699-41-2 ]
  • [ 32656-34-1 ]
  • [ 1078722-17-4 ]
YieldReaction ConditionsOperation in experiment
45 g In water at -0.16 - 74.84℃;
  • 34
  • [ 830-03-5 ]
  • [ 110-60-1 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
22% In water at 50℃; for 24h;
  • 35
  • [ 110-60-1 ]
  • [ 122-79-2 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
56% In water at 50℃; for 24h;
  • 36
  • [ 5699-41-2 ]
  • [ 411235-57-9 ]
  • [ 1228358-03-9 ]
YieldReaction ConditionsOperation in experiment
62% With [2,2]bipyridinyl; oxygen; copper diacetate; sodium carbonate In 1,2-dichloro-ethane at 70℃; for 2h; chemoselective reaction;
  • 37
  • [ 5699-41-2 ]
  • disodium adenosine-5' triphosphate [ No CAS ]
  • [ 121-44-8 ]
  • C16H28N7O13P3*C6H15N [ No CAS ]
YieldReaction ConditionsOperation in experiment
Stage #1: N-(4-aminobutyl)acetamide; disodium adenosine-5' triphosphate With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide In water for 2h; Stage #2: triethylamine In water
  • 38
  • [ 110-60-1 ]
  • [ 75-36-5 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
In dichloromethane at 4 - 20℃; Inert atmosphere;
  • 39
  • [ 5699-41-2 ]
  • [ 1419871-63-8 ]
  • [ 1419868-81-7 ]
YieldReaction ConditionsOperation in experiment
With HATU 2-Cyclopropyl-oxazole-4-carboxylic acid [5-(4- acetylamino-butylcarbamoyl)-2-(4-o-tolyl-piperazin-1-yl)-phenyl]-amide was prepared from N- (4-amino-butyl)-acetamide and 3-[(2-cyclopropyl-oxazole-4-carbonyl)-amino]-4-(4-o-tolyl- piperazin-1-yl)-benzoic acid obtained from the LiOH mediated hydrolysis of 3-[(2-cyclopropyl- oxazole-4-carbonyl)-amino]-4-(4-o-tolyl-piperazin-1-yl)-benzoic acid methyl ester followed by HATU amide coupling using the desired amine.LCMS (ESI) 559 (M+H); 1H NMR (400 MHz, DICHLOROMETHANE-cfe) δ ppm 1.07 - 1.18 (m, 4H) 1.53 - 1.70 (m, 4H) 2.00 (s, 3H) 2.05 - 2.15 (m, 1 H) 2.37 (s, 3H) 3.09 - 3.24 (m, 8H) 3.30 (q, 6.36 Hz, 2H) 3.43 - 3.51 (m, 2H) 6.22 - 6.47 (m, 1H) 6.68 (brs, 1H) 6.97 - 7.35 (m, 5H) 7.61 (dd, J=8.22, 2.07 Hz, 1H) 8.12 (s, 1H) 8.82 (d, .1=2.05 Hz, 1H) 9.94 (s, 1H).
  • 40
  • [ 5699-41-2 ]
  • [ 1604677-77-1 ]
  • [ 1612182-54-3 ]
YieldReaction ConditionsOperation in experiment
With triethylamine In butan-1-ol at 130℃; for 18h; 303 Example 303N-(4-[2-Amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)acetamide. Example 303N-(4-[2-Amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)acetamide.A solution of 4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine (25 mg; 0.1 mmol)in n-BuOH (1.0 ml) was heated at 130°C with N-(4-aminobutyl)acetamide (1 eq.)and triethylamine (1 eq). After 18 h the reaction was halted and evaporated. Theresidue was purified by preparative HPLC. LCMS [M+H] 368.
With triethylamine In butan-1-ol at 130℃; for 18h; 303 Example 303 N-(4-[2-Amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)acetamide. Example 303 N-(4-[2-Amino-6-(2,3-dichlorophenyl)pyrimidin-4-yl]amino}butyl)acetamide. A solution of 4-chloro-6-(2,3-dichlorophenyl)pyrimidin-2-amine (25 mg; 0.1 mmol) in n-BuOH (1.0 ml) was heated at 130°C with N-(4-aminobutyl)acetamide (1 equiv.) and triethylamine (1 eq). After 18 h the reaction was halted and evaporated. The residue was purified by preparative HPLC. LCMS [M+H]+ 368.
  • 41
  • [ 5699-41-2 ]
  • (2-((butyryloxy)methyl)thio)benzoic acid [ No CAS ]
  • ((2-((4-acetamidobutyl)carbamoyl)phenyl)thio)methyl butyrate [ No CAS ]
YieldReaction ConditionsOperation in experiment
41% Stage #1: (2-((butyryloxy)methyl)thio)benzoic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide at 23℃; for 1h; Inert atmosphere; Stage #2: N-(4-aminobutyl)acetamide With N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 23℃; for 12h; Inert atmosphere; 4.5.7 General procedure G for the synthesis of mercaptobenzamides of general structure 13 General procedure: Chloromethyl butyrate (1.00 equiv) and N,N-di-iso-propylethylamine (1.20 equiv) were sequentially added to a solution of thiosalicylic acid (1 equiv) in N,N-dimethylformamide (0.20M) and the resulting mixture was stirred at 23°C for 12h. 1,1′-Carbonyldiimidazole (1.00 equiv) was added to the reaction mixture, and the resulting mixture was stirred at 23°C for 1h. A solution of amine (specified below; 1.00 equiv) in N,N-dimethylformamide (4.0mL) and N,N-di-iso-propylethylamine (2.30 equiv) were sequentially added to the reaction mixture, and the resulting mixture was stirred at 23°C for 12h. The product mixture was concentrated, and the residue obtained was diluted with ethyl acetate (120mL). The diluted product mixture was transferred to a separatory funnel and sequentially washed with saturated aqueous sodium bicarbonate solution (1×50mL), water (1×50mL), and saturated aqueous sodium chloride solution (1×50mL). The organic layer was dried over sodium sulfate. The dried solution was filtered and the filtrate was concentrated. The residue thus obtained was purified by flash-column chromatography (as noted) to provide the mercaptobenzamide of general structure 13.
  • 42
  • [ 5699-41-2 ]
  • [ 322474-21-5 ]
  • 4-(2,3-bis(tert-butyloxycarbonyl)guanidino)butylacetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
55% In ethanol at 20℃; for 18h; 1 4-(2,3-Bis(tert-butyloxycarbonyl)guanidino)butylacetamide J-4: Commercially available N-acetylputrescine 14 (1.30 g, 1.00 mL, 9.99 mmol, 2.00 equiv) and 1,3-bis(tert- butoxycarbonyl)-2-methyl-2-thiopseudourea 11 (1.45 g, 4.99 mmol, 1.00 equiv) were dissolved in ethanol (95%, 50 mL). The homogeneous solution was stirred overnight (~18 hours) at rt. TLC indicated a complete consumption of starting material (5:4:1 EtOAc/hexanes/MeOH). The reaction mixture was concentrated to furnish a clear oil that was purified by silica gel column chromatography with an isocratic mixture of 5:4:1 EtOAc/hexanes/MeOH to afford 1.01 g (55%) of J-4 as a colorless solid. Mp 122.5-124.5. Anal. Calc’d for C15H23N4O5: C, 54,82; H, 8.66; N, 15.04. Found: C, 55.08; H, 8.55; N, 15.19.1H NMR (400 MHz, MeOH-d4) d 3.37 (t, J = 6.8 Hz, 2H), 3.20 (t, J = 6.6 Hz, 2H), 1.93 (s, 3H), 1.67- 1.54 (m, 4H), 1.53 (s, 9H), 1.47 (s, 9H);13C NMR (100 MHz, MeOH-d4) d 173.2, 164.5, 157.6, 154.2, 84.4, 80.3, 41.4, 40.1, 28.6, 28.2, 27.6, 27.5, 22.6.
  • 43
  • [ 5699-41-2 ]
  • [ 34840-26-1 ]
  • 4-(2,3-bis(ethoxycarbonyl)guanidino)butylacetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
67% In ethanol at 20℃; for 12h; 1 4-(2,3-Bis(ethoxycarbonyl)guanidino)butylacetamide J-3. To a solution of 13 (2.00 g, 8.54 mmol) in abs. ethanol (15 mL) was added a solution of commercially available N- acetylputrescine 14, CAS Reg. No.18233-70-0 (1.2 g, 9.2 mmol) in abs. ethanol (10 mL). After the reaction was stirred overnight at rt, the solvent was removed under reduced pressure. Addition of chloroform and evaporation was repeated twice to yield 3.4 g of a viscous oil, which on triturating with hexanes:Et2O (9:1) produced white solids that were separated and washed with hexanes:Et2O (9:1) and dried under vacuum to yield 1.8 g (67%) of J-3 as a colorless solid. Mp 95- 97 °C.1H NMR (400 MHz, CDCl3) d 11.70 (s, 1H), 8.36 (t, J = 5.7 Hz, 1H), 6.05 (s, 1H), 4.22 (q, J = 7.1 Hz, 2H), 4.14 (q, J = 7.1 Hz, 2H), 3.44 (q, J = 6.6 Hz, 2H), 3.29 (q, J = 6.4 Hz, 2H), 1.98 (s, 3H), 1.63 (p, J = 7.0 Hz, 2H), 1.55 (p, J = 7.2 Hz, 2H), 1.30 (td, J = 7.1, 2.6 Hz, 6H).
  • 44
  • [ 5699-41-2 ]
  • [ 62946-44-5 ]
  • 4-(2-(ethoxycarbonyl)guanidino)butylacetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
46% In ethanol at 20℃; for 18h; 1 4-(2-(ethoxycarbonyl)guanidino)butylacetamide J-6: Commercially available 16 (0.809 g, 4.99 mmol, 1.00 equiv) and N-acetylputrescine 14 (1.30 g, 1.00 mL, 9.99 mmol, 2.00 equiv) were dissolved in ethanol (95%, 50 mL). The homogeneous solution was stirred overnight (about 18 hours) at rt. TLC indicated a complete consumption of starting material (5:4:1 EtOAc/hexanes/MeOH). The reaction mixture was concentrated to a clear oil which was purified by silica gel column chromatography with an isocratic mixture of 5:4:1EtOAc/hexanes/MeOH. Concentration of the desired fractions afforded 0.56 g (46%) of J-6 as a cream colored solid. Mp 118-120 °C.1H NMR (400 MHz, MeOH-d4) d 3.97 (q, J = 7.1 Hz, 2H), 3.10 (dt, J = 9.9, 6.3 Hz, 4H), 1.83 (s, 3H), 1.51- 1.41 (m, 4H), 1.15 (t, J = 7.1 Hz, 3H).13C NMR (100 MHz, MeOH-d4) d 173.33, 61.66, 41.63, 40.08, 39.93, 28.20, 27.65, 27.54, 22.54, 14.94. MS (LCMS): 245 (M+1)+.
  • 45
  • [ 14464-29-0 ]
  • [ 110-60-1 ]
  • [ 5699-41-2 ]
YieldReaction ConditionsOperation in experiment
33% In dichloromethane at -78 - 20℃; for 16h; Inert atmosphere;
  • 46
  • [ 5699-41-2 ]
  • [ 72-89-9 ]
  • [ 3073-57-2 ]
YieldReaction ConditionsOperation in experiment
With triethanolamine; ethylenediaminetetraacetic acid; carnitine acetyltransferase; arylamine N-acetyltransferase 2*4, wild-type allele; acetylcarnitine; diothiothreitol In water at 37℃; for 18h; Enzymatic reaction;
  • 47
  • [ 5699-41-2 ]
  • [ 82414-35-5 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 3 steps 1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C / Inert atmosphere 2: acetic acid; palladium 10% on activated carbon; hydrogen / water / 4 h / 20 °C 3: arylamine N-acetyltransferase 2*4, wild-type allele; triethanolamine; acetylcarnitine; ethylenediaminetetraacetic acid; diothiothreitol; carnitine acetyltransferase / water / 18 h / 37 °C / pH 7.5 / Enzymatic reaction
  • 48
  • [ 5699-41-2 ]
  • [ 13431-24-8 ]
YieldReaction ConditionsOperation in experiment
Multi-step reaction with 2 steps 1: sodium cyanoborohydride; acetic acid / methanol / 24 h / 20 °C / Inert atmosphere 2: acetic acid; palladium 10% on activated carbon; hydrogen / water / 4 h / 20 °C
  • 49
  • [ 5699-41-2 ]
  • [ 65564-05-8 ]
  • [ 86563-01-1 ]
YieldReaction ConditionsOperation in experiment
100% With sodium cyanoborohydride; acetic acid In methanol at 20℃; for 24h; Inert atmosphere;
  • 50
  • [ 5699-41-2 ]
  • 7-bromo-3-cyclopropyl-4-(3-methyl-4-methylsulfonylphenyl)-1-tetrahydropyran-2-ylpyrazolo[4,3-c]pyridine [ No CAS ]
  • N-[4-[[3-cyclopropyl-4-(3-methyl-4-methylsulfonylphenyl)-1-tetrahydropyran-2-ylpyrazolo[4,3-c]pyridin-7-yl]amino]butyl]acetamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
68% With palladium diacetate; Cs2CO3; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene In 1,4-dioxane at 80℃; for 12h; Inert atmosphere; 103.1 Step 1 : N-[4-[[3-cyclopropyl-4-(3-methyl-4-methylsulfonyl-phenyl)-l-tetrahydropyran-2-yl- pyrazolo[4,3-c]pyridin-7-yl]amino]butyl]acetamide To a mixture of 7-bromo-3-cyclopropyl-4-(3-methyl-4-methylsulfonyl-phenyl)-l- tetrahydropyran-2-yl-pyrazolo[4,3-c]pyridine (Example 99, step 1) (80 mg, 0.2 mmol) in 1,4- dioxane (2 mL) was added cesium carbonate (266 mg, 0.8 mmol), N-(4-aminobutyl)acetamide (106 mg, 0.8 mmol), xantphos (11 mg, 0.02 mmol) and Pd(OAc)2 (4 mg, 0.02 mmol) was stirred at 80°C for 12 h under a nitrogen atmosphere. The reaction mixture was filtered and concentrated. Purification by reversed phase preparative HPLC afforded the title compound (60 mg, 68%) as a yellow solid. ([M+H]+ 540.1)
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