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[ CAS No. 570-23-0 ]

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Chemical Structure| 570-23-0
Chemical Structure| 570-23-0
Structure of 570-23-0 * Storage: {[proInfo.prStorage]}

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Product Details of [ 570-23-0 ]

CAS No. :570-23-0 MDL No. :MFCD00010299
Formula : C7H7NO3 Boiling Point : 344.4°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :153.14 g/mol Pubchem ID :-
Synonyms :

Safety of [ 570-23-0 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 570-23-0 ]

  • Upstream synthesis route of [ 570-23-0 ]
  • Downstream synthetic route of [ 570-23-0 ]

[ 570-23-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 570-23-0 ]
  • [ 35748-34-6 ]
YieldReaction ConditionsOperation in experiment
45% at 0 - 70℃; for 12 h; Inert atmosphere Synthesis of methyl 3-amino-2-hydroxybenzoate (XVII):XVIITo a stirred solution of 3-amino-2-hydroxybenzoic acid XII (0.5 g, 3.26 mmol) in MeOH (15 ml) was added sulfuric acid (1 ml) at 0°C under nitrogen atmosphere and the resulting mixture was heated at 70°C for 12 h. After completion of reaction, the reaction mixture was cooled, concentrated, washed with saturated NaHCC>3 solution and extracted with ethyl acetate. The organic layer was dried over Na2S04 and evaporated under reduced pressure to afford product XVII in 45percent yield.
25.9% for 55 h; Heating / reflux (1)
methyl 3-aminosalicylate
3-Aminosalicylic acid (690 mg, 4.51 mmol), methanol (45 ML), and conc. sulfuric acid (0.9 ML) were mixed, and heated for 55 hours under reflux..
The methanol was distilled off under reduced pressure..
To the residue was added cooled water..
The aqueous residue was made alkaline by addition of aqueous saturated sodium hydrogen carbonate under cooling with ice..
Thus precipitated crystalline product were collected by filtration, washed with two portions of water, and dried in vacuo at 40°C for 40 min., to give 710 mg of a pale pink crystalline product..
The product was suspended in chloroform (35 ML), and insolubles were removed by filtration..
The filtrate was dried over sodium sulfate and then concentrated under reduced pressure to give 181 mg (yield 25.9percent) of the desired compound in the form of a brown crystalline product. 1H NMR (CDCl3, 400 MHz) δ: 3.88 (2H, broad s), 3, 94 (3H, s), 6.71 (1H, dd, J=8Hz, 8Hz), 6.87 (1H, d, J=8Hz), 7.24 (1H, m), 10.88 (1H, s).
19% at 20℃; for 22 h; Heating / reflux EXAMPLE 392
3-[(2-Chlorobenzoyl)Amino]-2-[(2-Chlorophenyl)Methoxy]Benzoic Acid
A mixture of thionyl chloride (1.15 ML, 15.8 mmol) and methanol (20.0 ML) was stirred at room temperature for 30 min then treated with 3-amino-2-hydroxybenzoic acid (1.5 g, 9.79 mmol).The reaction mixture was stirred at room temperature for 2 h, refluxed for 20 h, cooled and concentrated.The crude product was partitioned between EtOAc (100 ML) and 5percent NAHCO3 solution (65 ML), back-extracting the aqueous phase with EtOAc (4*100 ML).The organic phase was washed with water (2*20 ML) and brine (20 ML), dried (MgSO4), filtered and concentrated to give a dark red solid (381 mg, 19percent).
Reference: [1] Patent: WO2011/72174, 2011, A1, . Location in patent: Page/Page column 146-147
[2] Patent: EP1452528, 2004, A1, . Location in patent: Page 18
[3] Patent: US2003/225091, 2003, A1, . Location in patent: Page 71
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