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Chemical Structure| 570409-63-1 Chemical Structure| 570409-63-1

Structure of 570409-63-1

Chemical Structure| 570409-63-1

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Product Details of [ 570409-63-1 ]

CAS No. :570409-63-1
Formula : C15H23N3O2
M.W : 277.36
SMILES Code : O=C(N1CC2=C(N=CC(N)=C2)C(C)(C)C1)OC(C)(C)C

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Application In Synthesis of [ 570409-63-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 570409-63-1 ]

[ 570409-63-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 14150-94-8 ]
  • [ 79099-07-3 ]
  • [ 74-88-4 ]
  • [ 570409-63-1 ]
YieldReaction ConditionsOperation in experiment
LDA (2.0 M solution, 5.0 mL) was added to a solution of tert-butyl 4-oxo-l- piperidinecarboxylate (2.03 g, 10.2 mmol) in 10 mL of anhydrous THF at -78 0C under N2. The mixture was stirred at -78 0C for 10 min., iodomethane (0.44 mL, 9.69 mmol) was added dropwise, the cold bath was removed, the reaction was gradually warmed to RT and stirred at RT for 20 min., then cooled at -78 0C. LDA (2.0 M solution, 4.60 ml) was added dropwise, after 20 min., iodomethane (0.44 mL) was added, the mixture was gradually warmed to RT overnight, quenched with NHtClfaq), and extracted with EtOAc5 removal of the solvents afforded colorless oil, which was a mixture of the starting material, mono-methylated product, and the desired compound. The mixture was used in the following reaction without purification. The mixture (1.5 g), l-methyl-3,5-dinitro- lH-pyridin-2-one (1.50 g), and 50 ml of ammonia solution (2.0 M solution in MeOH) in a sealed vessel was stirred at 60 C overnight. The volatiles were removed, the residue was mixed with Pd/C (10 wt%, 0.50 g) in 40 ml of MeOH was placed under H2, and stirred at RT for 2 h, filtered through Celite, condensed to afford a mixture containing tert-butyl 3-amino-8,8-dimethyl-7,8-dihydro-l,6-naphthyridine-6(5H)-carboxylate.
 

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